A5058354779- Polymer Surface Interaction Studies
- Hydrogels: synthesis, properties, applications
- Electrospun Nanofibers in Biomedical Applications
- Ionic liquids properties and applications
- Essential Oils and Antimicrobial Activity
- Silk-based biomaterials and applications
- Ureteral procedures and complications
- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Bone Tissue Engineering Materials
- Kidney Stones and Urolithiasis Treatments
- Chemical and Physical Properties in Aqueous Solutions
- Phase Equilibria and Thermodynamics
- Antimicrobial agents and applications
- Tissue Engineering and Regenerative Medicine
- Infectious Aortic and Vascular Conditions
- Nanocomposite Films for Food Packaging
- Advanced Drug Delivery Systems
- Surface Modification and Superhydrophobicity
- Nanoplatforms for cancer theranostics
- Calcium Carbonate Crystallization and Inhibition
- Polymer composites and self-healing
- Chemical Synthesis and Reactions
- Advanced Cellulose Research Studies
University of Minho
2014-2023
Barco (Belgium)
2022
UCLouvain
2012-2016
University of Lisbon
2012-2016
Stemmatters (Portugal)
2016
Materials Research Group (United States)
2015
The struggle between humans and pathogens has taken is continuing to take countless lives every year. As the misusage of conventional antibiotics increases, complexity associated with resistance mechanisms been evolving into gradually more clever mechanisms, diminishing effectiveness antibiotics. Hence, there a growing interest in discovering novel reliable therapeutics able infection, circumvent defend natural microbiome. In this regard, nature-derived phenolic compounds are gaining...
The breakthroughs achieved in green solvents promote the emergence of therapeutic deep eutectic (THEDES), which possess intriguing possible applications biomedical field. Herein, main aim was to unravel potential hydrophobic THEDES based menthol and saturated fatty acids with different chain lengths (e.g., stearic acid (SA), myristic (MA), lauric (LA)). Our comprehensive strategy resulted thermophysical characterization formulations, allow one identify most suitable molar ratio, as well...
Nanostructured three-dimensional constructs combining layer-by-layer technology (LbL) and template leaching were processed evaluated as possible support structures for cartilage tissue engineering. Multilayered formed by depositing the polyelectrolytes chitosan (CHT) chondroitin sulphate (CS) on either bidimensional glass surfaces or 3D packet of paraffin spheres. 2D CHT/CS multi-layered proved to attachment proliferation bovine chondrocytes (BCH). The was transposed level hierarchical...
In this work, we report the preparation of novel therapeutic deep eutectic solvents (THEDES) based on choline chloride (CC) and ascorbic acid (AA), in which dexamethasone (DEX) was successfully solubilized. THEDES were synthesized characterized for thermal behavior polarized optic microscopy to confirm formation a mixture. The solubility profile DEX solubilized greatly improved when compared with powder form. Additionally, diffusion permeability also slightly increased. antioxidant...
The potential of natural deep eutectic systems (NADESs) to efficiently extract astaxanthin (AXT) contained in crab shell wastes was evaluated. Different terpene-based mixtures were prepared and characterized. Aiming at maximizing the AXT recovery, we evaluated effect operating temperature time on extraction performance. As a proof concept, this paper also highlights NADESs for from shrimp shells, mussels, Haematococcus pluvialis. biological AXT-rich extracts; standard; NADESs, their...
Abstract Deep eutectic solvents have been recently reported as an interesting alternative to improve the therapeutic efficacy of conventional drugs, hence called deep (THEDES). The main objective this work was evaluate potential limonene (LIM) based THEDES new possible systems for cancer treatment. LIM is known antitumor activity, however it highly toxic and cell viability often compromised, thus compound not selective towards cells. Different on were developed unravel anticancer such...
Engineering metabolically demanding tissues requires the supply of nutrients, oxygen, and removal metabolic byproducts, as well adequate mechanical properties. In this work, we propose development chitosan (CHIT)/alginate (ALG) freestanding membranes fabricated by layer-by-layer (LbL) assembly. CHIT/ALG were cross-linked with genipin at a concentration 1 mg·mL–1 or 5 mg·mL–1. Mass transport properties glucose oxygen evaluated on membranes. The diffusion decreases increasing cross-linking...
We investigated the pH-dependent properties of multilayered films made chitosan (CHI) and alginate (ALG) focused on their postassembly response to different pH environments using a quartz crystal microbalance with dissipation monitoring (QCM-D), swelling studies, ζ potential measurements, dynamic mechanical analysis (DMA). In an acidic environment, multilayers presented lower values and, consequently, higher moduli when compared obtained for used during assembly (5.5). When were exposed...
Microbial infection is a serious and challenging clinical complication that has attracted widespread interest in last decades. In this context, we present strategy based on deep eutectic solvents (DES) to explore these unmet medical needs. DES systems saturated fatty acids, namely, capric acid (CA), myristic (MA), lauric (LA) stearic (SA) were produced fully characterized at physicochemical level. The thermal characterization results indicate depression of the melting point form when...
Enzymatic esterification is an effective route that can contribute for the separation of racemic (rac) mixtures and thus great importance pharmaceutical, food, cosmetic industries. All processes involved in this methodology should be environmentally friendly, biocompatible, fast, cost-effective. The use deep eutectic solvents (DESs) comply with all these metrics. In work, we report on DESs enzymatic menthol, one largest traded flavors aromas worldwide. Solid rac-menthol was mixed solid...
Effective antimicrobial treatment has been identified as a serious and unmet medical need. Herein, we present strategy based on deep eutectic systems (DES) to overcome current limitations, answering the need not only effectively kill bacterial agents but also avoid their adhesion proliferation, which is associated with biofilm formation have crucial impact virulence. To achieve such goal, natural (NADES) menthol (Me) saturated free fatty acids (FFA) were produced, fully physicochemical...
The design and production of structures with nanometer‐sized polymer films based on layer‐by‐layer (LbL) are particular interest for tissue engineering since they allow the precise control physical biochemical cues implantable devices. In this work, a method is developed preparation nanostructured hollow multilayers tubes combining LbL template leaching. aim to produce polyelectrolyte multilayer tuned physical‐chemical properties study their effects cell behavior. final tubular characterized...
Tissues presenting continuous variations of properties in one direction have inspired the development functional graded materials. In this work, we developed a new facile method for gradients chitosan (CHIT) and alginate (ALG) polyelectrolyte multilayers (PEMs) obtained layer-by-layer based on gradual dipping CHIT/ALG coated glass slides genipin solution. Stiffness were produced cm scale by varying reaction time with genipin. Quartz crystal microbalance, colorimetric measurements, trypan...
Treatment of microbial-related infections remains a clinical challenge that has been slowly aggravating over recent years, due to the dissemination resistance against currently applied treatment protocols. In this current scenario, design novel approaches is great importance, being prominent focus scientific community. years deep eutectic systems (DES) have gained attention community their remarkable physicochemical and biological properties, versatility, compliance with green chemistry...
Produce biodegradable nanoparticles to target antigen-presenting cells (APCs) and evaluate their potential be used as a vaccine delivery system.Untargeted PEGylated poly(d,l-lactic-co-glycolide)-based mannose-grafted were formulated physicochemically characterized. Immortalized primary APCs study nanoparticle internalization patterns. The endocytic pathways intracellular trafficking followed by also investigated.Nanoparticles displayed mannose residues available for binding at the surface....