A5033539889- Foot and Ankle Surgery
- Sports injuries and prevention
- Shoulder Injury and Treatment
- Bone fractures and treatments
- Orthopedic Surgery and Rehabilitation
- Lower Extremity Biomechanics and Pathologies
- Tendon Structure and Treatment
- Knee injuries and reconstruction techniques
- Cancer Genomics and Diagnostics
- Congenital heart defects research
- High voltage insulation and dielectric phenomena
- Cardiac Fibrosis and Remodeling
- Statistical Methods in Clinical Trials
- Lung Cancer Research Studies
- Bayesian Methods and Mixture Models
- Signaling Pathways in Disease
- Lung Cancer Treatments and Mutations
- Stoma care and complications
- Bone Tumor Diagnosis and Treatments
- Abdominal Surgery and Complications
- Extracellular vesicles in disease
- Acute Ischemic Stroke Management
- Advanced Clustering Algorithms Research
- Acute Kidney Injury Research
- Power Transformer Diagnostics and Insulation
Aintree University Hospitals NHS Foundation Trust
2025
University of Liverpool
2025
New York Medical College
2024
Eli Lilly (United States)
2017-2023
Sports Medicine Australia
2022-2023
Malankara Orthodox Syrian Church Medical College Hospital
2023
University Hospitals of Morecambe Bay NHS Foundation Trust
2021
Royal Lancaster Infirmary
2021
Cincinnati Children's Hospital Medical Center
2019-2021
University of Cincinnati
2020
Significance During the postnatal period, heart undergoes important changes, including cardiomyocyte cell-cycle arrest and loss of regenerative capacity. While other cell types have been better characterized, information related to cardiac fibroblasts (CFs) is limited. Here, we report a specialized population highly proliferative periostin-expressing (Postn+) in early that become quiescent at P30. In comparison, P7 Tcf21+ distinct gene expression from Postn+ CFs. Notably, CFs express...
Importance For hospitalized critically ill adults with suspected sepsis, procalcitonin (PCT) and C-reactive protein (CRP) monitoring protocols can guide the duration of antibiotic therapy, but evidence effect safety these remains uncertain. Objective To determine whether decisions based on assessment CRP or PCT safely results in a reduction therapy. Design, Setting, Participants A multicenter, intervention-concealed randomized clinical trial, involving 2760 (≥18 years), 41 UK National Health...
The incidence of knee injuries in sport, particularly involving the ACL, appears to be increasing yearly, especially younger age athletes. Even more concerning is frequency ACL reinjury also year after year. Improving objective criteria and testing methods used determine return play (RTP) readiness following surgery one aspect rehabilitation process that can significantly help reducing rates. Currently, majority clinicians are still using post operative time frames as their number criterion...
Background Anterior cruciate ligament (ACL) injury and reinjury rates are on the rise, despite improved surgical techniques prevention programs. ACL injuries also lead to a variety of neuroplastic neuromuscular alterations. Emerging research highlights importance addressing neurocognitive deficits that can persist after including altered proprioception, impaired motor control, muscle recruitment heightened reliance visual feedback. This suggests shift from subconscious movement, movements...
Fibrosis is a common feature of chronic kidney disease; however, no clinical therapies effectively target the progression fibrosis. Inhibition fibronectin polymerization with small peptide pUR4 attenuates fibrosis in liver and heart. Here, we show that decreases renal tissue remodeling using clinically relevant model injury, unilateral ischemia-reperfusion. This work highlights benefits inhibiting matrix polymerization, alone or conjunction cell-based therapies, as novel approach to diminish...
Anterior cruciate ligament (ACL) injury rates are on the rise, despite improved surgical techniques and prevention programs. While traditional rehabilitation emphasizes restoration of motion, strength, physical performance, emerging research highlights importance addressing neurocognitive deficits that can persist after injury. These deficits, including altered proprioception, impaired motor control muscle recruitment, as well heightened reliance visual feedback, significantly increase risk...
Abstract Background: Adjuvant ET has been the standard of care for patients with estrogen receptor-positive (ER+), human epidermal growth factor receptor 2-negative (HER2-) EBC. A significant proportion increased risk still experience disease relapse despite available and more optimum is needed to prevent developing incurable metastatic cancer. Distant recurrence ranges from 20% 40% after 5 years adjuvant ET, depending on clinicopathological (clin-path) features at diagnosis. Consequently,...
The incidence of upper extremity (UE) injuries in sport, particularly with the shoulder and elbow baseball/softball players, appears to be increasing yearly, especially younger age athletes. Improving objective criteria testing methods used determine return play (RTP) readiness following non-operative or post-operative management UE is one aspect rehabilitation process that may significantly help reducing reinjury rates. Currently, majority clinicians are still using post operative time...
A band separating device that uses an anisotropic metamaterial exhibiting negative refraction is designed and measured. The has frequency dispersion in one component of the permeability tensor. beam incident onto undergoes dependent reflection directing different bandwidths towards three distinct measurement ports. Design issues are discussed, results presented.
Golf is increasing in popularity with 24.8 million golfers the U.S. 2020, a 2% increase from previous year. This number increased to 37.5 2021 which can be further broken down 25.1 on course and 12.4 participating off activities. Playing golf does not come without risk of injury, an annual incidence between 15.8% 40.9% amateurs 31% professional golfers. Most injuries occur due overuse (82.6%) only small percentage single traumatic event (17.4%). Injuries most commonly at low back followed by...
3065 Background: Many PD-1/PD-L1 mAb are in development across a broad range of tumors. The expanded literature provided an opportunity to address critical question: if PD-1 mAbs targeting the receptor have different safety/efficacy profile than PD-L1 ligand. Direct comparison these would be ideal but highly unlikely. Methods: We performed meta-analysis using Bayesian model provide indirect based on data public domain including PubMed and key medical conference abstracts (eg ASCO, ESMO...
By Kevin E Wilk, Zachary M Thomas & 4 more. This month's Clinical Viewpoint is an invited clinical commentary that outlines the history, indications, and current protocol for rehabilitation of Internal Brace repair UCL at ASMI.
This article provides a summary of discussions from the American Statistical Association (ASA) Biopharmaceutical (BIOP) Section Open Forum organized by ASA BIOP Methods in Oncology Scientific Working Group coordination with US FDA Center Excellence and LUNGevity Foundation on June 24, 2021, January 13, 2022. Diverse stakeholders engaged discussion how best to use various innovative clinical trial designs designing future pediatric oncology trials. While standard randomized controlled trials...
Methods for summarizing case influence in Bayesian models take essentially two forms: (1) use common divergence measures calculating distances between the full-data posterior and case-deleted posterior, (2) measure impact of infinitesimal perturbations to likelihood study local influence. based on approach lead naturally considering behavior case-deletion importance sampling weights (the used approximate samples from using full posterior). curvature Kullback–Leibler a geometrically perturbed...
Two-incision endoscopic plantar fasciotomy (EPF) is an accepted surgical technique in the treatment of recalcitrant fasciitis. Single-incision a relatively new surgeons’ armamentarium; however, it not without pitfalls, specifically poor visualization. This article aims to help foot and ankle surgeon make smooth transition from 2-incision EPF single-incision while maintaining optimum Levels Evidence: Level V: Expert opinion
SUMMARY Leveraging historical data into the design and analysis of phase 2 randomized controlled trials can improve efficiency drug development programs. Such approaches reduce sample size without loss power. Potential issues arise when current control arm is inconsistent with data, which may lead to biased estimates treatment efficacy, power, or inflated type 1 error. Consideration as how borrow information important, in particular, adjustment for prognostic factors should be considered....