A5010674996- Treatment of Major Depression
- Functional Brain Connectivity Studies
- Mental Health Research Topics
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Neurotransmitter Receptor Influence on Behavior
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neural and Behavioral Psychology Studies
- Bipolar Disorder and Treatment
- Neuroendocrine regulation and behavior
- EEG and Brain-Computer Interfaces
- Child and Adolescent Psychosocial and Emotional Development
- Maternal Mental Health During Pregnancy and Postpartum
- Neuroscience and Neuropharmacology Research
- Personality Disorders and Psychopathology
- Hormonal Regulation and Hypertension
- Cognitive Functions and Memory
- Psychopathy, Forensic Psychiatry, Sexual Offending
- Reproductive Health and Contraception
- Endometriosis Research and Treatment
- Cognitive Abilities and Testing
- Attachment and Relationship Dynamics
- Epilepsy research and treatment
- Personality Traits and Psychology
- Superconductivity in MgB2 and Alloys
Copenhagen University Hospital
2017-2025
Rigshospitalet
2017-2025
University of Copenhagen
2017-2024
Institute of Neurobiology
2024
University of Bristol
2023
ORCID
2023
Importance The cerebral serotonin 4 (5-HT ) receptor is a promising novel target for treatment of major depressive disorder (MDD), and pharmacological stimulation the 5-HT has been associated with improved learning memory in healthy individuals. Objective To map neurobiological signatures patients untreated MDD compared controls to examine association between binding cognitive functions depressed state. Design, Setting, Participants This case-control study used baseline data from NeuroPharm...
Between 30 and 50% of patients with major depressive disorder (MDD) do not respond sufficiently to antidepressant regimens. The conventional pharmacological treatments predominantly target serotonergic brain signaling but better tools predict treatment response identify relevant subgroups MDD are needed support individualized mechanistically targeted strategies. aim this study is investigate antidepressant-free using neuroimaging, electrophysiological, molecular, cognitive, clinical...
ABSTRACT Introduction Patients with mood disorders, especially, major depressive disorder (MDD) and bipolar (BD), are at heightened risk of relapse psychiatric rehospitalizations. Therefore, there is an urgent need to identify modifiable biomarkers inform personalized intensified prevention strategies for those the greatest hospital readmissions. Brain structural measures subserving cognitive function hold particular promise among potential predictive biomarkers. Methods In present study,...
Objective Sex steroid hormones potently shape brain functions, including those critical to maintain mental health such as serotonin signaling. Use of oral contraceptives (OCs) profoundly changes endogenous sex hormone levels and dynamics. Recent register‐based studies show that starting an OC is associated with increased risk developing depression. Here, we investigate whether use OCs in healthy women a marker the system terms 4 receptor (5‐HT4R) imaging. Methods [ 11 C]SB207145‐PET imaging...
Background: Major depressive disorder (MDD) is a prevalent neuropsychiatric illness for which it important to resolve underlying brain mechanisms. Current treatments are often unsuccessful, precipitating need identify predictive markers. Aim: We evaluated (1) alterations in responses an emotional faces functional magnetic resonance imaging (fMRI) paradigm individuals with MDD, compared controls, (2) whether pretreatment predicted antidepressant treatment response, and (3) pre–post change...
Abstract Background Methylation of serotonin-related genes has been proposed as a plausible gene-by-environment link which may mediate environmental stress, depressive and anxiety symptoms. DNA methylation is often measured in blood cells, but little known about the association between this peripheral epigenetic modification brain serotonergic architecture. Here, we evaluated whole-blood-derived four CpG sites serotonin transporter ( SLC6A4 ) six tryptophan hydroxylase 2 TPH2 gene in-vivo...
Cognitive disturbances in major depressive disorder (MDD) constitute a critical treatment target and hold promise as an early predictor of antidepressant response; yet their clinical relevance is not fully established. Therefore, we here investigate if (1) cognitive performance improves over the course (2) at baseline predictive response. In NeuroPharm study (clinical trial id: NCT02869035), 92 antidepressant-free patients with moderate to severe episode were assessed comprehensive test...
BackgroundNeurocognitive impairments are associated with poor clinical and employment outcomes in individuals affective disorders. However, little is known about their associations long-term such as psychiatric hospitalizations, socio-demographic indicators other than employment. In the largest longitudinal study of neurocognition disorders to date, we investigate role neurocognitive on hospitalizations conditions.MethodsThe included 518 bipolar or major depressive disorder. Neurocognitive...
Abstract Background Although aggression is conceptualized as a dimensional construct with violent behavior representing the extreme end of spectrum, studies on involvement personality traits in human have typically only included data restricted spectrum aggressive behaviors. Methods In current study, we therefore examine whether trait associated five‐factor model an enriched sample 259 men broad continuum aggression, ranging from very low to high including 39 incarcerated offenders. All...
Abstract Concurrent anxiety is frequent in major depressive disorder and a shared pathophysiological mechanism between other symptoms plausible. The serotonin 4 receptor (5-HT R) has been implicated both depression anxiety. This the first study to investigate association cerebral 5-HT R binding patients with before after antidepressant treatment response. Ninety-one drug-free were positron emission tomography scanned ligand [ 11 C]-SB207145. Depression severity concurrent was measured at...
Abstract Background Major Depressive Disorder (MDD) is a heterogenous brain disorder, with potentially multiple psychosocial and biological disease mechanisms. This also plausible explanation for why patients do not respond equally well to treatment first- or second-line antidepressants, i.e., one-third one-half of remit in response treatment. To map MDD heterogeneity markers enable precision medicine approach, we will acquire several possible predictive across domains, e.g., psychosocial,...
Abstract Background Cognitive disturbances are common and disabling features of major depressive disorder (MDD). Previous studies provide limited insight into the co-occurrence hot (emotion-dependent) cold (emotion-independent) cognitive in MDD. Therefore, we here map both cognition depressed patients compared to healthy individuals. Methods We collected neuropsychological data from 92 antidepressant-free MDD 103 controls. All participants completed a comprehensive test battery assessing...
While several electroencephalogram (EEG)-based biomarkers have been proposed as diagnostic or predictive tools in major depressive disorder (MDD), there is a clear lack of replication studies this field. Markers that link clinical features such disturbed wakefulness regulation MDD with neurophysiological patterns are particularly promising candidates for e.g., EEG-informed choices antidepressive treatment. We investigate if we an independent sample can replicate abnormal findings...
Background Hormonal contraceptive (HC) use has been associated with an increased risk of developing a depressive episode. This might be related to HC’s effect on the serotonergic brain system as suggested by recent cross-sectional data from our group, which show that healthy oral (OC) users relative non-users have lower cerebral serotonin 4 receptor (5-HT4R) levels. Here, we determine if 5-HT4R binding differs between HC non-users, OC users, and hormonal intrauterine device (HIUD) among...
Women who use oral contraceptives (OCs) may have a higher risk of developing depression, which is associated with both vulnerability to stress and cognitive dysfunction. OCs disrupt the hypothalamic-pituitary-gonadal (HPG) axis by suppressing endogenous sex steroid production including estradiol. The HPG hypothalamic-pituitary-adrenal (HPA) are known interact, possibly through modulations driven affect HPA regulation capacity, i.e., disturb cortisol dynamics such as awakening response (CAR),...
Previous studies have suggested that the loudness dependence of auditory evoked potential (LDAEP) is associated with effectiveness antidepressant treatment in patients major depressive disorders (MDD). Furthermore, both LDAEP and cerebral serotonin 4 receptor (5-HT4R) density inversely related to brain levels. We included 84 MDD 22 healthy controls examined association between response its 5-HT4R density. Participants underwent EEG neuroimaging [11C]SB207145 PET. Thirty-nine were re-examined...
Brain morphology has been suggested to be predictive of drug treatment outcome in major depressive disorders (MDD). The current study aims at evaluating the performance pretreatment structural brain magnetic resonance imaging (MRI) measures predicting a MDD large single-site cohort, and, importantly, assess generalizability these findings an independent cohort. random forest, boosted trees, support vector machines and elastic net classifiers were evaluated response remission following eight...
Disruptions in hot cognition, i.e., the processing of emotionally salient information, are prevalent most neuropsychiatric disorders and constitute a potential treatment target. EMOTICOM is first comprehensive neuropsychological test battery developed specifically to assess cognition. The aim study was validate establish Danish language version reference data for battery. To evaluate psychometric properties 11 tasks, we collected from 100 healthy participants (50 males, 50 females) including...
Rumination is a maladaptive response to distress characteristic of Major Depressive Disorder (MDD). It unclear what degree rumination associated with depression severity prior treatment and how it responds antidepressant treatment. Therefore, we evaluated the association between in 92 untreated patients MDD explored changes after initiation medication.
Synapses are fundamental to the function of central nervous system and implicated in a number brain disorders. Despite their pivotal role, comprehensive imaging resource detailing distribution synapses human has been lacking until now. Here, we employ high-resolution PET neuroimaging healthy humans (17F/16M) create 3D atlas synaptic marker Synaptic Vesicle glycoprotein 2A (SV2A). Calibration absolute density values (pmol/ml) was achieved by leveraging postmortem autoradiography data. The...