A5065982883- Tracheal and airway disorders
- Head and Neck Cancer Studies
- Reconstructive Surgery and Microvascular Techniques
- Voice and Speech Disorders
- Salivary Gland Tumors Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Dysphagia Assessment and Management
- Transplantation: Methods and Outcomes
- Organ and Tissue Transplantation Research
- Airway Management and Intubation Techniques
- Parathyroid Disorders and Treatments
- Trauma Management and Diagnosis
- Thyroid Cancer Diagnosis and Treatment
- Tumors and Oncological Cases
- Ear and Head Tumors
- Head and Neck Anomalies
- Thyroid and Parathyroid Surgery
- Cancer Diagnosis and Treatment
- Reconstructive Facial Surgery Techniques
- Oral and Maxillofacial Pathology
- Medical Imaging and Pathology Studies
- Esophageal and GI Pathology
- Cleft Lip and Palate Research
- Oral health in cancer treatment
- Pituitary Gland Disorders and Treatments
KU Leuven
2016-2025
Creative Commons
2022
Cancer Institute (WIA)
2013-2021
Universitair Ziekenhuis Leuven
1995-2014
AZ Sint-Jan
2012
Rafael Advanced Defense Systems (Israel)
1992-2007
Reconstruction of long-segment tracheal defects requires a vascularized allograft. We report successful allotransplantation after indirect revascularization the graft in heterotopic position. Immunosuppressive therapy was administered before operation, and allograft wrapped recipient's forearm fascia. Once achieved, mucosal lining replaced progressively with buccal mucosa from recipient. At 4 months, chimera fully lined mucosa, which consisted respiratory epithelium donor After withdrawal...
Abstract In September 2020, the surgeon Paulo Macchiarini, who used stem cell technology to enable transplants of artificial and donor trachea, was charged with aggravated assault in Sweden. this comment, we argue that Ethics Council Karolinska Institute should have considered issues from philosophy science when they were brought their attention, rather than dismiss them as irrelevant research ethics. We demonstrate how conceptual a philosophy-of-science-kind about clinical medical practice...
The first vascularized tracheal allotransplantation was performed in 2008. Immunosuppression stopped after forearm implantation and grafting of the recipient mucosa to internal site transplant. Nine months implantation, allograft transplanted defect on radial blood vessels. Since then, four additional patients have undergone allotransplantation, three (patients 2-4) for long-segment stenosis one (patient 5) a low-grade chondrosarcoma. Our goal reduce time between orthotopic transplantation...
Fluorodeoxyglucose (FDG) whole body positron emission tomography (PET) scan is increasingly used in the diagnostic work-up or follow-up of patients. In these conditions, positive PET scans with unexpected hot spots within thyroid region could be defined as FDG-PET incidentaloma (in analogy sonographic nodules). We describe eight consecutive patients referred to endocrine department because "hot spots," incidentally detected by (September 1999 March 2001). Using ultrasound, fine needle...
Trisomy 3 represents the most frequent and consistent chromosomal abnormality characterizing recently defined entity marginal zone B‐cell lymphoma (MZBCL). By cytogenetic analysis and/or fluorescence in situ hybridization (FISH) on interphase nuclei we found an increased copy number of chromosome 22/36 (61%) successfully analysed cases, including 8/12 cases with extranodal MZBCL, 8/13 nodal 6/11 patients splenic MZBCL. Sensitivity cytogenetics was somewhat higher than that conventional...
Abstract BACKGROUND: Prognostic indices for recurrence‐free interval in patients with parotid carcinoma were developed and validated a nationwide database. International validation would increase generalizability. METHODS: In Belgian‐German database that contained 237 consecutive carcinoma, pretreatment prognostic index (PS1) post‐treatment (PS2) by calculating both each patient, comparing coefficients, constructing survival curves, the concordance measure C, performing Wald tests scale...
Abstract In order to evaluate the vocal quality of tracheo-oesophageal and oesophageal speech, several objective acoustic parameters were measured in waveform (fundamental frequency, perturbation) frequency spectrum (harmonic prominence, spectral slope). Twelve patients using speech (with Provox® valve) 12 for at least two months, participated. The main results that voices more often showed a detectable fundamental this was fairly stable; there also tendency clearly defined harmonics speech....
1,25-Dihydroxyvitamin D(3) (1,25(OH)(2)D(3)), the active form of vitamin D, mediates antitumor effects in various cancers. The expression key players D signaling thyroid tumors was investigated. Vitamin receptor (VDR) and CYP27B1 CYP24A1 (respectively activating catabolizing D) studied (RT-PCR, immunohistochemistry) normal thyroid, follicular adenoma (FA), differentiated cancer (DTC) consisting papillary (PTC) (FTC) subtype, anaplastic (ATC). VDR, CYP27B1, increased FA DTC compared with...
Purpose Subglottic stenosis (SGS) is defined as an obstruction of the subglottic area, potentially extending towards first tracheal rings. Although endoscopic procedures are frequently preferred first-line treatment, (partial) cricotracheal resection (PCTR) offers most durable results. This study aims at reporting and analysing complications respiratory vocal outcomes after PCTR. Methods For this retrospective cohort analysis, files 37 patients with SGS who underwent PCTR in a tertiary...