A5057302682- Sarcoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Bone fractures and treatments
- Management of metastatic bone disease
- Vascular Tumors and Angiosarcomas
- Musculoskeletal synovial abnormalities and treatments
- Orthopedic Infections and Treatments
- Cardiac tumors and thrombi
- Soft tissue tumor case studies
- Orthopaedic implants and arthroplasty
- Acute Myeloid Leukemia Research
- Hip disorders and treatments
- Cancer Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Shoulder Injury and Treatment
- Reconstructive Surgery and Microvascular Techniques
- Oral and Maxillofacial Pathology
- Surgical site infection prevention
- Bone Metabolism and Diseases
- Total Knee Arthroplasty Outcomes
- Single-cell and spatial transcriptomics
- Knee injuries and reconstruction techniques
- Medical Imaging Techniques and Applications
- Immune cells in cancer
- Medical Imaging and Pathology Studies
Clinica Universidad de Navarra
2016-2025
Universidad de Navarra
2011-2023
MD Anderson Cancer Center Madrid
2023
Hospital Infantil Universitario Niño Jesús
2021
Navarre Institute of Health Research
2015
Universidad de Salamanca
2009
Tel Aviv University
2003
Tel Aviv Sourasky Medical Center
2003
Turkish Armed Forces
2003
Abstract Learning Objectives After completing this course, the reader will be able to: Describe major enchondroma distribution patterns that were identified in study.Identify variables are predictive for secondary transformation of over lifetime individuals with Ollier disease or Maffucci syndrome. CME This article is available continuing medical education credit at CME.TheOncologist.com Background. Enchondromatosis characterized by presence multiple benign cartilage lesions bone. While...
Early hematopoiesis is a continuous process in which hematopoietic stem and progenitor cells (HSPCs) gradually differentiate toward specific lineages. Aging myeloid malignant transformation are characterized by changes the composition regulation of HSPCs. In this study, we used single-cell RNA sequencing (scRNA-seq) to characterize an enriched population human HSPCs obtained from young elderly healthy individuals. Based on their transcriptional profile, identified proportions compartments...
Background: Pulmonary metastases from bone sarcomas occur in approximately 40% of the cases. The combination both chemotherapy and surgical resection is currently standard treatment options for these patients. We aim to study influence different prognostic factors on long-term survival. Methods: reviewed survival rate 52 consecutive patients with pulmonary sarcomas. All them were previously treated submitted metastasectomy at our institution 1996 2006. Clinical demographic variables, related...
Osteosarcoma (OS) is the most prevalent osseous tumour in children and adolescents and, within this, lung metastases remain one of factors associated with a dismal prognosis. At present, genetic determinants driving pulmonary metastasis are poorly understood. We adopted novel strategy using robust filtering analysis transcriptomic profiling osteoblastic cell populations derived from human chemo-naive primary tumours displaying extreme phenotypes (indolent versus metastatic) to uncover...
Myelodysplastic syndromes (MDS) are hematopoietic stem cell (HSC) malignancies characterized by ineffective hematopoiesis, with increased incidence in older individuals. Here we analyze the transcriptome of human HSCs purified from young and healthy adults, as well MDS patients, identifying transcriptional alterations following different patterns expression. While aging-associated lesions seem to predispose myeloid transformation, disease-specific may trigger development. Among MDS-specific...
Histologic grade, size, and depth are well-known prognostic factors in soft tissue sarcomas (STS). Small (< 5 cm) superficial STS generally have an excellent prognosis when treated with appropriate surgery. However, they often misdiagnosed mistreated. We reported that midterm follow-up (5 to 7 years), patients unplanned resections of tumors positive margins who immediately underwent a reoperation margin-widening re-resection postoperative radiotherapy had survival comparable were initially...
We compared several image methods in the evaluation of possible physeal effect 47 osteosarcomas and 18 Ewing's sarcomas children. The minimal follow-up was 3 years (range, 3-17). In histological study, physis affected 53% cases. correlated findings from different methods. There were more false-positive than false-negative results, computed tomography magnetic resonance imaging (MRI) studies, there no false negatives. accuracy MRI (predictive positive value plus predictive negative value)...
Isolated pulmonary metastases from soft tissue sarcomas (STS) occur in approximately 20% of the cases. Chemotherapy and surgical resection are current standard treatment options for these patients. Our goal was to identify any prognostic factors patients as well estimate their long-term survival rate. We examined a series twenty-two consecutive with STS, treated our institution 1996 2006. Univariate (log-rank Cox-regression) analysis performed significant factor. Five-year rates were...
We compared several image methods in the evaluation of possible physeal effect 47 osteosarcomas and 18 Ewing's sarcomas children. The minimal follow-up was 3 years (range, 3-17). In histological study, physis affected 53% cases. correlated findings from different methods. There were more false-positive than false-negative results, computed tomography magnetic resonance imaging (MRI) studies, there no false negatives. accuracy MRI (predictive positive value plus predictive negative value)...
With a view to identify the proteins involved in transformation, metastasis or chemoresistance pediatric osteosarcoma, we carried out new experimental approach based on comparison of proteomic profile paired samples osteosarcoma and normal bone tissues from same patient. The profiles five pairs cell lines (normal vs tumoral) were obtained by two-dimensional difference gel electrophoresis. We detected 56 differential protein spots (t test, p < 0.05). Subsequent characterization...
Introduction . The aim of this study is to compare outcomes in three groups STS patients treated our specialist centre: referred immediately after an inadequate initial treatment, a local recurrence, and directly, prior any treatment. Patients methods We reviewed all nonmetastatic extremity-STS with minimum follow-up 2 years. compared patient groups: those directly centre (group A), excision B), recurrence C). Results included 174 patients. Disease-free survival was 73%, 76%, 28% A, B, C,...
Abstract Purpose: Osteosarcoma is the most prevalent bone tumor in children and adolescents. At present, mechanisms of initiation, maintenance, metastasis are poorly understood. The purpose this study was to identify relevant molecular targets pathogenesis osteosarcoma. Experimental Design: Tumor chemonaive osteoblastic populations paired control normal osteoblasts were isolated characterized phenotypically from seven osteosarcoma patients. Global transcriptomic profiling analyzed by robust...
Objectives: The European League Against Rheumatism (EULAR) and the Federation of National Associations Orthopaedics Traumatology (EFORT) have recognised importance variation in diagnostic therapeutic performance across disciplines, found consensus starting task forces aiming at achieving uniformity, identified medical conditions with which representatives both organisations will frequently be confronted common clinical practice. aim present work was to establish recommendations for diagnosis...
ABSTRACT Osteosarcoma is the most common malignant bone tumor in children and adolescents. The presence of metastases lack response to conventional treatment are major adverse prognostic factors. Therefore, there an urgent need for new strategies that overcome both these problems. Our purpose was elucidate whether use oncolytic adenovirus Δ24-RGD alone or combination with standard chemotherapy would be effective, vitro vivo, against osteosarcoma. results showed exerted a potent antitumor...