A5016006549- Surfactants and Colloidal Systems
- Analytical Chemistry and Sensors
- NMR spectroscopy and applications
- Spectroscopy and Quantum Chemical Studies
- Photosynthetic Processes and Mechanisms
- Molecular Junctions and Nanostructures
- Conducting polymers and applications
- Lipid Membrane Structure and Behavior
- Material Dynamics and Properties
- Advanced biosensing and bioanalysis techniques
- Photochemistry and Electron Transfer Studies
- Nanowire Synthesis and Applications
- Photoreceptor and optogenetics research
- Gold and Silver Nanoparticles Synthesis and Applications
- Analytical Chemistry and Chromatography
- Electrochemical sensors and biosensors
- Pickering emulsions and particle stabilization
- Electrochemical Analysis and Applications
- Laser-Ablation Synthesis of Nanoparticles
- Neuroscience and Neural Engineering
- Ionic liquids properties and applications
- Thermodynamic properties of mixtures
- Liquid Crystal Research Advancements
- Polymer Surface Interaction Studies
- Advanced Neuroimaging Techniques and Applications
University of Bari Aldo Moro
2016-2025
Consorzio Interuniversitario per lo Sviluppo dei Sistemi a Grande Interfase
2015-2024
Istituto di Nanotecnologia
2018-2021
National Research Council
2018-2020
Surface (Brazil)
2016-2017
Polytechnic University of Bari
2017
University of Florence
2013-2014
Florence (Netherlands)
2014
Unilever (United Kingdom)
2010
University of Molise
1999-2009
Abstract Peripheral events in olfaction involve odorant binding proteins (OBPs) whose role the recognition of different volatile chemicals is yet unclear. Here we report on sensitive and quantitative measurement weak interactions associated with neutral enantiomers differentially to OBPs immobilized through a self-assembled monolayer gate an organic bio-electronic transistor. The transduction remarkably as transistor output current governed by small capacitance protein layer undergoing...
Label-free single-molecule detection has been achieved so far by funnelling a large number of ligands into sequence single-binding events with few recognition elements host on nanometric transducers. Such approaches are inherently unable to sense cue in bulk milieu. Conceptualizing cells' ability at the physical limit means highly-packed elements, millimetric sized field-effect-transistor is used detect single molecule. To this end, gate bio-functionalized self-assembled-monolayer 1012...
Electrolyte-gated organic field-effect transistors are successfully used as biosensors to detect binding events occurring at distances from the transistor electronic channel that much larger than Debye length in highly concentrated solutions. The sensing mechanism is mainly capacitive and due formation of Donnan's equilibria within protein layer, leading an extra capacitance (C DON) series gating system. As a service our authors readers, this journal provides supporting information supplied...
Anchored, biotinylated phospholipids forming the capturing layers in an electrolyte-gated organic field-effect transistor (EGOFET) allow label-free electronic specific detection at a concentration level of 10 nM high ionic strength solution. The sensing mechanism is based on clear capacitive effect across PL involving charges target molecules.
Bio-sensing represents one of the most attractive applications carbon material based electronic devices; nevertheless, complete integration bioactive transducing elements still a major challenge, particularly in terms preserving biological function and specificity while maintaining sensor's performance. This review highlights recent advances realization field-effect transistor (FET) sensors that comprise bio-receptor within FET channel. A birds-eye view will be provided promising classes...
Biosystems integration into an organic field-effect transistor (OFET) structure is achieved by spin coating phospholipid or protein layers between the gate dielectric and semiconductor. An architecture directly interfacing supported biological to OFET channel proposed and, strikingly, both electronic properties biointerlayer functionality are fully retained. The platform bench tests involved OFETs integrating phospholipids bacteriorhodopsin exposed 1-5% anesthetic doses that reveal...
In the last decade, saliva has been suggested as non-invasive diagnostic fluid, suitable for clinical use alternatively to blood serum and plasma. However, applicability of hampered so far by inadequate sensitivity current methods detect lower salivary concentrations many biomarkers monitored in products. Herein, a label-free biosensor based on electrolyte-gated organic thin-film transistor (EGOTFT) developed detection at physical limit C-reactive protein (CRP) human saliva. CRP is key...
The increasing interest in technologies capable of tracking a biomarker down to the physical limit points toward new opportunities early diagnostics progressive diseases. Indeed, single-molecule detection are foreseen enable clinicians associate tiniest increase with progression disease, particularly at its stage. Bioelectronic organic transistors represent an extremely powerful tool achieve label-free and clinically relevant biomarkers. These electronic devices millimetric size future could...
Quaternary water-in-oil microemulsion of a cationic surfactant (cetyltrimethylammonium bromide, CTAB), n-hexane, water, and n-pentanol has been investigated using conductivity, quasi-elastic light scattering, near-infrared absorption spectroscopy, pulsed field gradient spin-echo NMR measurements. The conductivity behavior shows features characteristic the migration charged droplets. Consequently, charge fluctuation model, data were correlated with droplet radius obtained from self-diffusion...
Abstract Bioconjugated gold surfaces constitute interesting platforms for biosensing applications. The immobilization of antibodies such as anti‐immunoglobulin G and M (anti‐IgG anti‐IgM) on electrodes via self‐assembled monolayers (SAMs) is here studied a model system further immunoassays development. biolayer characterized by means X‐ray photoelectron spectroscopy (XPS), atomic force microscopy (AFM), dedicated thin‐film transistor (TFT)‐based platform electrochemical surface plasmon...
Immunoglobulin M (IgM) single-molecule and label-free detection is demonstrated, for the first time, by means of an electrolyte-gated thin-film transistor. The sensor integrates a millimeter-wide self-assembled monolayer (SAM) that includes trillions anti-IgM capturing proteins. This adds generality to already introduced single molecule with transistor (SiMoT) platform. Besides extremely high sensitivity, SAM confers SiMoT bioelectronic selectivity here assessed measuring differential...
Electrolyte gated thin film transistors (TFTs) based on sol–gel processed zinc oxide (ZnO) are investigated using imidazolium-based ionic liquids (ILs), namely [bmim][BF<sub>4</sub>] and [bmim][PF<sub>6</sub>], as electrolytes.
Triblock copolymers of poly(ethylene oxide) and poly(propylene oxide)-based matrices, such as Poloxamer 407 (P407) or Pluronic® F127, are extensively utilized in drug delivery permeation systems due to their FDA approval listing the US European Pharmacopoeias. The study hypothesizes that incorporating 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) celecoxib-HP-β-CD inclusion complex into a 16 wt% P407 chitosan blend an aqueous acetic acid solution will affect system's rheological structural...
The isothermal quasi-ternary-phase diagram of the lecithin−cyclohexane−water system was determined at 25 °C using a combination polarizing microscopy, small-angle X-ray diffraction, and NMR techniques. contains four lyotropic liquid-crystalline phases two isotropic liquid phases. Apart from lamellar (Lα) phase, there are only reverse-type aggregates with water interior, in addition to an essentially pure whose relative locations phase follow sequence (from oil corner surfactant corner):...
Trehalose is a nonreducing disaccharide of glucose found in organisms, which can survive adverse conditions such as extreme drought and high temperatures. Furthermore, isolated structures, enzymes or liposomes, embedded trehalose are preserved against stressing [see, e.g., Crowe, L. M. Comp. Biochem. Physiol. A 2002, 131, 505−513]. Among other hypotheses, protective effect has been suggested to stem, the case proteins, from formation water-mediated, hydrogen bond network, anchors protein...
A Functional Bio-Interlayer Organic Field-Effect Transistor (FBI-OFET) sensor, embedding a streptavidin protein capturing layer, capable of performing label-free selective electronic detection biotin at 3 part per trillion (mass fraction) or 15 pM, is proposed here. The response shows logarithmic dependence spanning over 5 orders magnitude analyte concentration. optimization the FBI analytical performances achieved by depositing layer through controllable Layer-by-Layer (LbL) assembly, while...