A5030339405- Analytical Chemistry and Sensors
- Conducting polymers and applications
- Molecular Junctions and Nanostructures
- Nanowire Synthesis and Applications
- Gas Sensing Nanomaterials and Sensors
- Advanced biosensing and bioanalysis techniques
- Advanced Chemical Sensor Technologies
- Organic Electronics and Photovoltaics
- Advanced Sensor and Energy Harvesting Materials
- Neuroscience and Neural Engineering
- Electrochemical sensors and biosensors
- ZnO doping and properties
- Electrochemical Analysis and Applications
- Thin-Film Transistor Technologies
- Force Microscopy Techniques and Applications
- Mechanical and Optical Resonators
- Ionic liquids properties and applications
- Analytical Chemistry and Chromatography
- Advanced Biosensing Techniques and Applications
- Dielectric materials and actuators
- Mass Spectrometry Techniques and Applications
- Silicon Nanostructures and Photoluminescence
- Nanomaterials and Printing Technologies
- Copper-based nanomaterials and applications
- Organic Light-Emitting Diodes Research
University of Bari Aldo Moro
2013-2020
Consorzio Interuniversitario per lo Sviluppo dei Sistemi a Grande Interfase
2017-2020
Centre for Research in Engineering Surface Technology
2020
Istituto di Fotonica e Nanotecnologie
2017-2018
Surface (Brazil)
2017
University of Florence
2014
National Centre of Scientific Research "Demokritos"
2005-2012
Institute of Nuclear and Particle Physics
2008-2009
Label-free single-molecule detection has been achieved so far by funnelling a large number of ligands into sequence single-binding events with few recognition elements host on nanometric transducers. Such approaches are inherently unable to sense cue in bulk milieu. Conceptualizing cells' ability at the physical limit means highly-packed elements, millimetric sized field-effect-transistor is used detect single molecule. To this end, gate bio-functionalized self-assembled-monolayer 1012...
Abstract Organic bioelectronic sensors are gaining momentum as they can combine high‐performance sensing level with flexible large‐area processable materials. This opens to potentially highly powerful systems for point‐of‐care health monitoring and diagnostics at low cost. Prominent detect biochemical recognition events, electrolyte‐gated organic field‐effect transistors (EGOFETs) electrochemical (OECTs) easily fabricated operated. EGOFETs recently shown be capable of label‐free...
The detection of protein biomarkers is great importance in the early diagnosis severe pathological states. Although last decade many approaches to achieve ultra-sensitive have been developed, most them require complicated assay set-ups, hindering their adoption point-of-care applications and on-spot diagnosis. Here we show an organic electrochemical transistor (OECT) biosensor printed on plastic substrates that can selectively detect Immunoglobulin G (IgG) with unprecedented attomolar limit....
A systematic comparison between electrochemical and organic bioelectronic sensors reveals a unified rational description for transistor amplified detection.
In the last decade, saliva has been suggested as non-invasive diagnostic fluid, suitable for clinical use alternatively to blood serum and plasma. However, applicability of hampered so far by inadequate sensitivity current methods detect lower salivary concentrations many biomarkers monitored in products. Herein, a label-free biosensor based on electrolyte-gated organic thin-film transistor (EGOTFT) developed detection at physical limit C-reactive protein (CRP) human saliva. CRP is key...
The increasing interest in technologies capable of tracking a biomarker down to the physical limit points toward new opportunities early diagnostics progressive diseases. Indeed, single-molecule detection are foreseen enable clinicians associate tiniest increase with progression disease, particularly at its stage. Bioelectronic organic transistors represent an extremely powerful tool achieve label-free and clinically relevant biomarkers. These electronic devices millimetric size future could...
This review discusses the state-of-the-art strategies for realizing TFTs by printing compatible techniques, focusing attention on label-free electronic biosensors.
Abstract Bioconjugated gold surfaces constitute interesting platforms for biosensing applications. The immobilization of antibodies such as anti‐immunoglobulin G and M (anti‐IgG anti‐IgM) on electrodes via self‐assembled monolayers (SAMs) is here studied a model system further immunoassays development. biolayer characterized by means X‐ray photoelectron spectroscopy (XPS), atomic force microscopy (AFM), dedicated thin‐film transistor (TFT)‐based platform electrochemical surface plasmon...
Immunoglobulin M (IgM) single-molecule and label-free detection is demonstrated, for the first time, by means of an electrolyte-gated thin-film transistor. The sensor integrates a millimeter-wide self-assembled monolayer (SAM) that includes trillions anti-IgM capturing proteins. This adds generality to already introduced single molecule with transistor (SiMoT) platform. Besides extremely high sensitivity, SAM confers SiMoT bioelectronic selectivity here assessed measuring differential...
Electrolyte gated thin film transistors (TFTs) based on sol–gel processed zinc oxide (ZnO) are investigated using imidazolium-based ionic liquids (ILs), namely [bmim][BF<sub>4</sub>] and [bmim][PF<sub>6</sub>], as electrolytes.
Abstract Early diagnosis of the infection caused by human immunodeficiency virus type-1 (HIV-1) is vital to achieve efficient therapeutic treatment and limit disease spreading when viremia at its highest level. To this end, a point-of-care HIV-1 detection carried out with label-free, low-cost, ultra-sensitive screening technologies would be great relevance. Herein, label-free single molecule p24 capsid protein large ( wide-field ) single-molecule transistor (SiMoT) sensor proposed. The...
A sensitive EGOFET biosensor fabricated by anchoring bioprobes through a UV crosslinked poly(acrylic acid) coating deposited on an organic semiconductor.
Single-molecule sensing is becoming a major driver in biomarker assays as it foreseen to enable precision medicine enter into everyday clinical practice. However, among the single-molecule detection methods proposed so far, only few are fully exploitable for ultrasensitive label-free assay of biofluids. Firstly introduced platforms encompass low-background-noise fluorescent microscopy well plasmonic and electrical nanotransducers; these generally able sense at nanomolar concentration level...
We demonstrate the realization of first label-free optical biosensor based on room temperature luminescence silicon nanowires (NWs) tested for selective detection C-reactive protein in human serum. High aspect ratio Si NW arrays used as sensing interface, are synthesized by a fast, low cost and industrially compatible approach. biosensors fast offer broad concentration dynamic range that can be tuned according to different applications. Moreover, platform is endowed with high selectivity...
Bottom- and top-contact organic thin film transistors (OTFTs) were fabricated, using poly(3-hexylthiophene-2,5-diyl) (P3HT) poly[2,5-bis(3-tetradecylthiophen-2-yl)thieno[3,2-b]thiophene] (PBTTT-C16) as p-type channel semiconductors. Four different types of OTFTs fabricated investigated gas sensors against three volatile compounds, with associated dipole moments. The OTFT-based sensor responses evaluated static transient current measurements. A comparison between the architectures relative...
A jellified alginate based capsule serves as biocompatible and biodegradable electrolyte system to gate an organic field-effect transistor fabricated on a flexible substrate. Such allows operating thiophene polymer transistors below 0.5 V through electrical double layer formed across ion-permeable polymeric electrolyte. Moreover, biological macro-molecules such glucose-oxidase streptavidin can enter into the gating capsules that serve also delivery system. An enzymatic bio-reaction is shown...
Robust electrolyte-gated organic field-effect-transistors (OFETs) are particularly needed for the development of biosensing devices. However, when a FET biosensor operates in aqueous environments or even real biological fluids, some critical issues may arise due to possible lack environmental long-term and/or operational stability. An important source instability is associated with degradation electronic channel materials such as instance, poly-3-hexylthiophene (P3HT), benchmark commercially...
Thiolated self-assembled monolayers (SAMs) are typically used to anchor on a gold surface biomolecules serving as recognition elements for biosensor applications. Here, the design and synthesis of N-(2-hydroxyethyl)-3-mercaptopropanamide (NMPA) in biotinylated mixed SAMs is proposed an alternative strategy with respect on-site multistep functionalization prepared from solutions commercially available thiols. In this study, SAM deposited 10:1 solution 3-mercaptopropionic acid (3MPA)...
We report on the use of a polyanionic proton conductor, poly(acrylic acid), to gate poly[2,5-bis(3-tetradecylthiophen-2-yl)thieno[3,2-b]thiophene]-based organic field-effect transistor (OFET). A planar configuration OFET is evaluated, and electrical performance implementation flexible substrate are discussed.