A5032463264- Immune Response and Inflammation
- Immune cells in cancer
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- interferon and immune responses
- Immune Cell Function and Interaction
- Viral Infections and Vectors
- Neuroinflammation and Neurodegeneration Mechanisms
- Olfactory and Sensory Function Studies
Duke University
2022-2024
National Taiwan University
2020-2023
Aberrant neutrophil extracellular trap (NET) formation and the loss of barrier integrity in inflamed intestinal tissues have long been associated with inflammatory bowel disease (IBD). However, whether NETs alter epithelium permeability during colitis remains elusive. Here, we demonstrated that promote breakdown function for pathogenesis inflammation mouse models colitis. were abundant colon mice experimentally induced by dextran sulfate sodium (DSS) or 2,4,6-trinitrobenzene sulfonic acid...
Increased neutrophil extracellular trap (NET) formation and abundant NET-associated proteins are frequently found in the inflamed colon of patients with inflammatory bowel disease. Peptidyl arginine deiminase 4 (PAD4) activation is essential for generation NET NET-mediated pathogenesis. However, role PAD4-dependent murine disease models molecular mechanisms responsible altered gut barrier function unknown.Wild-type Pad4 knockout (Pad4-/-) mice were administrated 3% dextran sulfate sodium...
Production of a functional peripheral T cell compartment typically involves massive expansion the bone marrow progenitors that seed thymus. There are two main phases during development, following lineage commitment double-negative (DN) 2 cells and after successful rearrangement selection for TCRβ chains in DN3 thymocytes, which promotes transition DN4 to DP stage. The signals driving DN2 thymocytes well studied. However, factors regulating proliferation survival remain poorly understood....
The olfactory mucosa is important for both the sense of smell and as a mucosal immune barrier to upper airway brain. However, little known about how system mediates conflicting goals neuronal maintenance inflammation in this tissue. A number cell populations reside within yet we have understanding these resident cells functionally interact with chemosensory environment. Identifying interactions will allow therapeutic manipulations that treat disorders such post-viral dysfunction. Macrophages...