A5102995056- Nutrition and Health in Aging
- Frailty in Older Adults
- Pharmacological Effects and Toxicity Studies
- Nutritional Studies and Diet
- Cervical Cancer and HPV Research
- Health Systems, Economic Evaluations, Quality of Life
- Genital Health and Disease
- Electrolyte and hormonal disorders
- Diet and metabolism studies
- Pharmacological Effects of Natural Compounds
- Epilepsy research and treatment
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Technology Adoption and User Behaviour
- Immune cells in cancer
- Reproductive tract infections research
- Cardiac, Anesthesia and Surgical Outcomes
- Advanced Image and Video Retrieval Techniques
- RNA and protein synthesis mechanisms
- Bone health and osteoporosis research
- Hip and Femur Fractures
- QR Code Applications and Technologies
- Immune Response and Inflammation
- Genetic Associations and Epidemiology
- Occupational and environmental lung diseases
- Salivary Gland Disorders and Functions
National Taiwan University Hospital
2015-2024
National Taiwan University
2010-2023
Soochow University
2023
Advanced Semiconductor Engineering (Taiwan)
2023
China Medical University
2008-2022
China Medical University Hospital
2011-2022
Chang Gung Memorial Hospital
2022
Institute of Biomedical Sciences, Academia Sinica
2012-2021
Kaohsiung Veterans General Hospital
2021
National Defense Medical Center
2016
Aberrant neutrophil extracellular trap (NET) formation and the loss of barrier integrity in inflamed intestinal tissues have long been associated with inflammatory bowel disease (IBD). However, whether NETs alter epithelium permeability during colitis remains elusive. Here, we demonstrated that promote breakdown function for pathogenesis inflammation mouse models colitis. were abundant colon mice experimentally induced by dextran sulfate sodium (DSS) or 2,4,6-trinitrobenzene sulfonic acid...
We report the first genome-wide association study of a joint analysis using 795 Han Chinese individuals with treatment-refractory schizophrenia (TRS) and 806 controls. Three loci showed suggestive significant TRS were identified. These include: rs10218843 (P = 3.04×10−7) rs11265461 1.94×10−7) are adjacent to signaling lymphocytic activation molecule family member 1 (SLAMF1); rs4699030 1.94×10−6) rs230529 1.74×10−7) located in gene nuclear factor kappa light polypeptide enhancer B-cells...
Identification of frailty is crucial to guide patient care for the elderly. The Clinical Frailty Scale (CFS) a reliable, synthesis and clinical judgment-based tool. However, validated Chinese version CFS (CFS-C) lacking. aim this study describe translation process into traditional evaluate its reliability validity in geriatric population Taiwan.This cross-sectional recruited 221 outpatients aged 65 years or older at medical center Taipei, Taiwan. was produced following Brislin's model....
Abstract Human papillomavirus (HPV) 52 and 58 are oncogenic HPV types prevalent in Asia. Our study aims to explore intratypic variants of Taiwan. A total 11,923 women were enrolled from seven townships 1991–1992. DNA their cervical cells was detected typed by EasyChip® blot. Among 424 participants infected with and/or 58, nucleotide variations determined cell samples 406 the polymerase chain reaction sequencing long control region, E6 E7 genes. Nonprototype‐like including lineages B C 278...
Diet quality plays an important role in dementia prevention. It remains unclear how the joint effect of vegetable variety and diet affects cognition. This study aimed to explore association with cognitive decline older adults. prospective cohort (2011–2015) included 436 community-dwelling elders Taipei. quality, assessed by modified Alternative Healthy Eating Index (mAHEI), was computed from a food frequency questionnaire at baseline (2011–2013). Vegetable indicated number different groups,...
Abstract Human papillomavirus (HPV) causes cervical neoplasia; but limited data are available from Asia. We conducted a large‐scale community‐based cohort study in Taiwan to estimate prevalence of genotype‐specific HPV infection and neoplasia. Following written informed consent, cells for cytology testing were collected 11,923 participants (aged 30–65 years old, mean 46.3) 1991–1992. Genotyping was performed using MY11/GP6+ PCR‐based Blot (EasyChip) 39 types. The overall 16.2% 10,602...
Polymorphisms of β2-adrenergic receptor (ADRB2) and β3-adrenergic (ADRB3) have been reported to be associated with obesity in adults adolescents, although study results controversial. The aim the present was investigate association polymorphisms ADRB2 (Arg16Gly, Gln27Glu) ADRB3 (Trp64Arg) adolescent Taiwan.A total 559 volunteers equal numbers female male were enrolled. Participants divided into two groups: obese (body mass index [BMI]≥ 95th percentile) normal weight (BMI 15th-85th...
Patients with Parkinson disease (PD) were known to have increased risk of complications during hospitalization. The purpose this study is validate the global features postoperative adverse outcomes for patients PD. Using reimbursement claims from Taiwan's National Health Insurance Research Database, we conducted a nationwide retrospective cohort 6455 preoperative PD receiving major surgery 2008 2012. With propensity score matching procedure, 12,910 surgical without selected comparison....
// Wen-Ling Liao 1, 2, * , Wen-Jane Lee 3, Ching-Chu Chen 4, 5, Chieh Hsiang Lu 6, 7, 8, Chien-Hsiun 9 Yi-Chun Chou I-Te 10, 11, 12 Wayne H-H Sheu 12, 13, 14 Jer-Yuarn Wu Chi-Fan Yang Chung-Hsing Wang 15, 16 Fuu-Jen Tsai 17, 18 1 Graduate Institute of Integrated Medicine, China Medical University, Taichung, Taiwan 2 Center for Personalized University Hospital, 3 Department Research, Taichung Veterans General 4 Division Endocrinology and Metabolism, 5 School Chinese 6 Internal Ditmanson...
Abstract The associations between variants of human papillomavirus (HPV) 16 and risk cervical neoplasia have been reported, but nucleotide variations HPV in Asian populations their association with not evaluated extensively. During 1991–1992, 11,923 women from seven townships Taiwan were enrolled. DNA cells was detected genotyped using EasyChip blot. Nucleotide the long control region (LCR), E6, E7 genes determined sequencing for 170 16‐positive samples. variant most prevalent (81.8%)...
To identify susceptibility genes to nonfamilial hypokalemic periodic paralysis (hypoKPP) consisting of thyrotoxic (TPP) and sporadic (SPP) explore the potential pathogenic mechanisms.We enrolled patients with hypoKPP not carrying mutations in CACNA1S, SCN4A, KCNJ18, or KCNJ2 conducted genome-wide association analyses comparing 77 TPP 32 SPP 1,730 controls a Han Chinese population Taiwan. Replication was performed using an independent cohort 50 TPP, 22 SPP, 376 controls.We identified 4 single...
In this paper, we propose a new protocol which integrates intra-flow network coding based opportunistic routing with inter-flow coding, called CAOR, for lossy wireless networks. environment, each linear combination of packets in batch may not be able to arrive at forwarder intact. The challenge problem is determine XORed transmissions on the partially received within all combinations (i.e., coded packets). design goal our solution reduce number and increase opportunity through finding proper...
Abstract Introduction Low‐energy extracorporeal shock wave therapy (LiESWT) is a new potential treatment for intractable interstitial cystitis/bladder pain syndrome (IC/BPS), and this paper will evaluate its therapeutic effects on IC/BPS. Materials Methods This prospective clinical trial enrolled 30 women who have been diagnosed with IC/PBS to receive LiESWT at an intensity of 0.25 mJ/mm 2 frequency 3 pulses/second, total 3000 pulses within 8 weeks. And we assessed questionnaires (including...
Purpose: This study was conducted to investigate risk factors of obesity and its associated health problems in adolescence Taiwan. Methods: We enrolled 559 adolescent volunteers with equal numbers females males 2008. Participants were divided into two groups: obese (body mass index [BMI] ?95th percentile) normal-weight adolescents (BMI: 15th ? 85th percentile). Each them completed a questionnaire about lifestyle parents stature. Results: Obese mother had high likelihood having girls boys...
Aberrant neutrophil extracellular trap (NET) formation and the loss of barrier integrity in inflamed intestinal tissues have long been associated with inflammatory bowel disease (IBD). However, whether NETs alter epithelium permeability during colitis remains elusive. Here, we demonstrated that promote breakdown function for pathogenesis inflammation mouse models colitis. were abundant colon mice experimentally induced by dextran sulfate sodium (DSS) or 2,4,6-trinitrobenzene sulfonic acid...
Thirty-day hospital readmission rate significantly raised with advanced age. The performance of existing predictive models for risk remained uncertain in the oldest population. We aimed to examine effect geriatric conditions and multimorbidity on among older adults aged 80 over. This prospective cohort study enrolled patients discharged from a ward at tertiary hospital, phone follow-up 12 months. Demographics, multimorbidity, were assessed before discharge. Logistic regression conducted...
Early recognition of older people at risk undesirable clinical outcomes is vital in preventing future disabling conditions. Here, we report the prognostic performance an electronic frailty index (eFI) comparison with traditional tools among nonfrail and prefrail community-dwelling adults. The study to investigate predictive utility a deficit-accumulation eFI community elders without overt frailty.Participants aged 65-80 years Clinical Frailty Scale 1-3 points were recruited followed for 2...
Abstract This study was designed to test whether Alpinia pricei (AP), a member of the ginger family indigenous Taiwan, reduced metabolic syndrome induced by sucrose‐containing drinking water in C57BL/6J mice. Mice given chow diet were divided into control group (C) or 30% sucrose (SW) drink ad libitum . After 22 weeks, mice SW subdivided and + AP groups, latter receiving with an ethanol extract (1500 mg/kg dosage). Four weeks later, bio‐indexes associated measured. Compared C group, had...
Aim: The patients in the permanent diabetes insipidus (DI) group are more likely to have severe TBI, which is defined by a post-resuscitational and pre-sedational Glasgow Coma Scale (GCS) score of 8/15 or less. This study presents case permanent, central DI following mild traumatic brain injury with post-resuscitation GCS 13/15.