A5101837166- Frailty in Older Adults
- Nutrition and Health in Aging
- Epigenetics and DNA Methylation
- Neurological disorders and treatments
- Immune Response and Inflammation
- Viral gastroenteritis research and epidemiology
- Parkinson's Disease Mechanisms and Treatments
- Advanced MEMS and NEMS Technologies
- Antimicrobial Resistance in Staphylococcus
- Helicobacter pylori-related gastroenterology studies
- Prostate Cancer Treatment and Research
- Advanced Surface Polishing Techniques
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- RNA modifications and cancer
- Viral Infections and Outbreaks Research
- Health Systems, Economic Evaluations, Quality of Life
- Ubiquitin and proteasome pathways
- Cancer, Hypoxia, and Metabolism
- Animal Virus Infections Studies
- Sepsis Diagnosis and Treatment
- Skin Protection and Aging
- Cerebral Venous Sinus Thrombosis
- Inflammasome and immune disorders
- Satellite Communication Systems
- Glycogen Storage Diseases and Myoclonus
Johns Hopkins Medicine
2023-2024
Johns Hopkins University
2023-2024
National Taiwan University Hospital
2013-2023
Kaohsiung Veterans General Hospital
2023
National Tsing Hua University
2005-2022
National Sun Yat-sen University
2022
Providence University
2012
Taichung Veterans General Hospital
2012
Fudan University
2007
University of Wisconsin–Madison
1996
Staphylococcus aureus skin colonization and eosinophil infiltration are associated with many inflammatory disorders, including atopic dermatitis, bullous pemphigoid, Netherton’s syndrome, prurigo nodularis. However, whether there is a relationship between S. eosinophils how this interaction influences inflammation largely undefined. We show in preclinical mouse model that epicutaneous exposure induced eosinophil-recruiting chemokines into the skin. Remarkably, we found had comparable...
Identification of frailty is crucial to guide patient care for the elderly. The Clinical Frailty Scale (CFS) a reliable, synthesis and clinical judgment-based tool. However, validated Chinese version CFS (CFS-C) lacking. aim this study describe translation process into traditional evaluate its reliability validity in geriatric population Taiwan.This cross-sectional recruited 221 outpatients aged 65 years or older at medical center Taipei, Taiwan. was produced following Brislin's model....
Staphylococcus aureus is the leading cause of skin and soft tissue infections a major health burden due to emergence antibiotic-resistant strains. To address unmet need alternative treatments antibiotics, better understanding protective immune mechanisms against S. infection warranted. Here, we report that tumor necrosis factor (TNF) promoted protection in skin, which was mediated by bone marrow–derived cells. Furthermore, neutrophil-intrinsic TNF receptor (TNFR) signaling directed immunity...
Rationale:The progression of prostate cancer (PCa) to castration-resistant PCa (CRPC) despite continuous androgen deprivation therapy is a major clinical challenge.Over 90% patients with CRPC exhibit sustained receptor (AR) signaling.KDM4B that removes the repressive mark H3K9me3/2 transcriptional activator AR and has been implicated in development CRPC.However, mechanisms KDM4B involvement remain largely unknown.Here, we sought demonstrate molecular pathway mediated by provide...
Cholesterol-α-glucosyltransferase (CGT) encoded by the type 1 capsular polysaccharide biosynthesis protein J (capJ) gene of Helicobacter pylori converts cellular cholesterol into cholesteryl glucosides. H. infection induces autophagy that may increase bacterial survival in epithelial cells. However, role CGT exploits lipid rafts interfering with for macrophages has not been investigated. Here, we show wild-type carrying modulates to trigger and restrain autophagosome fusion lysosomes,...
Castration-resistant prostate cancer (CRPC) with sustained androgen receptor (AR) signaling remains a critical clinical challenge, despite depletion therapy. The Jumonji C-containing histone lysine demethylase family 4 (KDM4) members, KDM4A‒KDM4C, serve as coactivators of AR to promote tumor growth in and are candidate therapeutic targets overcome mutations/alterations-mediated resistance CRPC.In this study, using structure-based approach, we identified natural product, myricetin, able block...
Intrarectal simian immunodeficiency virus (SIV) infection in rhesus macaques is a model for sexual transmission of primate retroviruses. Phylogenetic studies on envelope gene sequences that were present blood following intrarectal SIV inoculation provided evidence selective amplification subset viruses the inoculum and defined one amino acid sequence uniquely associated with infection. Both persistent transient viremia states observed after Immune responses persistently infected animals...
Abstract KDM4/JMJD2 Jumonji C-containing histone lysine demethylases (KDM4A–D) constitute an important class of epigenetic modulators in the transcriptional activation cellular processes and genome stability. Interleukin-8 (IL-8) is overexpressed gastric cancer, but mechanisms particularly role regulation IL-8, are unclear. Here, we report that KDM4B, not KDM4A/4C, upregulated IL-8 production absence or presence Helicobacter pylori . Moreover, KDM4B physically interacts with c-Jun on , MMP1...
Abstract PKM2 is a key metabolic enzyme central to glucose metabolism and energy expenditure. Multiple stimuli regulate PKM2’s activity through allosteric modulation post-translational modifications. Furthermore, can partner with KDM8, an oncogenic demethylase enter the nucleus serve as HIF1α co-activator. Yet, mechanistic basis of exon-10 region in regulation nuclear translocation remains unclear. Here, we determined crystal structures kinetic coupling constants tumor-related mutants (H391Y...
Sparse code multiple access (SCMA) is a promising code-domain non-orthogonal (NOMA) technique that supports high-level connectivity. Through the combination of SCMA and multiple-input multiple-output (MIMO) techniques, MIMO-SCMA schemes are capable enhancing overall spectral efficiency. This paper proposes novel designs for both uplink downlink Rayleigh fading channels. Rather than directly combining spatial multiplexing techniques presented in previous literature, proposed consider not only...
Thirty-day hospital readmission rate significantly raised with advanced age. The performance of existing predictive models for risk remained uncertain in the oldest population. We aimed to examine effect geriatric conditions and multimorbidity on among older adults aged 80 over. This prospective cohort study enrolled patients discharged from a ward at tertiary hospital, phone follow-up 12 months. Demographics, multimorbidity, were assessed before discharge. Logistic regression conducted...
Early recognition of older people at risk undesirable clinical outcomes is vital in preventing future disabling conditions. Here, we report the prognostic performance an electronic frailty index (eFI) comparison with traditional tools among nonfrail and prefrail community-dwelling adults. The study to investigate predictive utility a deficit-accumulation eFI community elders without overt frailty.Participants aged 65-80 years Clinical Frailty Scale 1-3 points were recruited followed for 2...
Laboratory studies of arenaviruses have been limited to parenteral routes infection; however, recent epidemiological implicate virus ingestion as a natural route infection. Accordingly, we developed model for oral and gastric infection with lymphocytic choriomeningitis enable mucosal transmission vaccination by this additional route.
This prospective study aims to determine predictive factors for patients be discharged home after receiving post-acute care (PAC) services and improve the case-finding criteria PAC in Taiwan. Elder admitted Taichung Veterans General Hospital treatment of an acute illness were assessed by simplified comprehensive geriatric assessment (CGA) clinical evaluation. Patients with functional recovery potential transferred community hospitals further service. Discharging status from a unit or...
Targeted temperature management (TTM) is recommended for postresuscitation care of patients with sudden cardiac arrest (SCA) and its implementation remains challenging. This study aimed to evaluate the newly designed Quality Improvement Project (QIP) improve quality TTM outcomes SCA.Patients who experienced out-of-hospital (OHCA) in-hospital (IHCA) return spontaneous circulation (ROSC) were treated in our hospital between January 2017 December 2019 enrolled retrospectively. All included...
This study presents a novel single proof-mass 3-axis capacitive-type accelerometer design consisting of poly-Si rib-proofmass, springs, high-aspect-ratio in-plane sensing electrodes, and plate-type out-of-plane electrodes. has three merits to increase the sensitivity, (1) large area gap-closing electrodes with differential capacitive-sensing capability; (2) electrodes; (3) electrical routings for are considered, (4) thick ribs remarkably proof-mass. The is implemented using well-known two...
Predictive metabolic biomarkers for the recurrent luminal breast cancer (BC) with hormone receptor (HR)-positive and human epidermal growth factor type 2 (HER2)-negative are lacking. High levels of O-GlcNAcylation (O-GlcNAc) pyruvate kinase isoenzyme M2 (PKM2) associated malignancy in BC; however, association recurrence risk remains unclear. We first conduct survival analysis by using METABRIC dataset to assess correlation PKM2 expression BC clinical outcomes. Next, patients HR+/HER2- were...
A 60-year-old man with a history of atrial fibrillation had an acute onset ballistic movements the left limbs sensory extinction (video on Neurology® Web site at [www.neurology.org][1]). The patient was treated risperidone and anticoagulant; symptoms subsided 3 days later. Brain MRI showed infarction right posterior parietal lobe (figure 1) SPECT revealed hypoperfusion in frontoparietal areas 2). [1]: http://www.neurology.org/