A5063148346- Receptor Mechanisms and Signaling
- Neuropeptides and Animal Physiology
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Lipid Membrane Structure and Behavior
- Neuroscience and Neuropharmacology Research
- Cellular transport and secretion
- Reproductive Biology and Fertility
- Glycosylation and Glycoproteins Research
- Phosphodiesterase function and regulation
- Neurobiology and Insect Physiology Research
- Autophagy in Disease and Therapy
- Cytokine Signaling Pathways and Interactions
- Chemokine receptors and signaling
- Calpain Protease Function and Regulation
- Nanowire Synthesis and Applications
- Prostate Cancer Treatment and Research
- Takotsubo Cardiomyopathy and Associated Phenomena
- Growth Hormone and Insulin-like Growth Factors
- Endometrial and Cervical Cancer Treatments
- Cardiovascular Conditions and Treatments
- Renal and related cancers
- TGF-β signaling in diseases
- interferon and immune responses
- Organic Electronics and Photovoltaics
University of California, San Francisco
2022-2024
Taipei Veterans General Hospital
2021
National Yang Ming Chiao Tung University
2012-2021
National Tsing Hua University
2016-2021
Taichung Veterans General Hospital
2021
Kaohsiung Medical University
2021
Memorial Hospital of South Bend
2006
Cells interpret a variety of signals through G-protein-coupled receptors (GPCRs) and stimulate the generation second messengers such as cyclic adenosine monophosphate (cAMP). A long-standing puzzle is deciphering how GPCRs elicit different physiological responses despite generating similar levels cAMP. We previously showed that some generate cAMP from both plasma membrane Golgi apparatus. Here we demonstrate cardiomyocytes distinguish between subcellular inputs to outputs. show leads...
Dopamine is a key catecholamine in the brain and kidney, where it involved number of physiological functions such as locomotion, cognition, emotion, endocrine regulation, renal function. As membrane-impermeant hormone neurotransmitter, dopamine thought to signal by binding activating receptors, members G protein coupled receptor (GPCR) family, only on plasma membrane. Here, using novel nanobody-based biosensors, we demonstrate for first time that D1 (D1DR), primary mediator dopaminergic...
Chemokines play pivotal roles in the recruitment of various immune cells to diverse tissues both physiological and pathological conditions. CXCL17 is an orphan chemokine preliminarily found be involved tumor angiogenesis. However, its protein nature, as well endogenous bioactivity, has not been clarified. Using real-time PCR, immunohistochemical staining, Western blotting, we that highly expressed a constitutive inducible manner rat gastric mucosa, where it undergoes endoproteolysis during...
BMP8A activates distinct sets of SMADs to control the proliferation and differentiation spermatogonia in mice.
Rationale:The progression of prostate cancer (PCa) to castration-resistant PCa (CRPC) despite continuous androgen deprivation therapy is a major clinical challenge.Over 90% patients with CRPC exhibit sustained receptor (AR) signaling.KDM4B that removes the repressive mark H3K9me3/2 transcriptional activator AR and has been implicated in development CRPC.However, mechanisms KDM4B involvement remain largely unknown.Here, we sought demonstrate molecular pathway mediated by provide...
Abstract Gonadotropin signaling plays an indispensable role in ovarian cancer progression. We previously have demonstrated that thyrostimulin and thyroid-stimulating hormone receptor (TSHR), the most ancient glycoprotein pair evolved much earlier than gonadotropin systems, co-exist ovary. However, whether thyrostimulin-driven TSHR activation contributes to progression a similar way receptors has never been explored. In this study, we first found is expressed both rat normal surface...
// Ting-Yu Lin 1 , Fang-Ju Wu Chia-Lin Chang 2 Zhongyou Li Ching-Wei Luo Department of Life Sciences and Institute Genome Sciences, National Yang-Ming University, Taipei 112, Taiwan Obstetrics Gynecology, Gung Memorial Hospital Linkou Medical Center, Kweishan, Taoyuan 333, Correspondence to: Luo, e-mail: cwluo@ym.edu.tw Keywords: neuromedin U, NMUR2, endometrial cancer, adhesion signaling, G protein-coupled receptor Received: August 05, 2015 Accepted: January 22, 2016 Published: February 03,...
Kaposi's sarcoma-associated herpesvirus (KSHV) is the causative agent of sarcoma (KS), an AIDS-defining cancer with abnormal angiogenesis. The high incidence KS in human immunodeficiency virus (HIV)-infected AIDS patients has been ascribed to interaction between HIV type 1 (HIV-1) and KSHV, focusing on secretory proteins. HIV-1 secreted protein Tat found synergize KSHV lytic proteins induce However, impact underlying mechanisms KSHV-infected endothelial cells undergoing viral reactivation...
Neuromedin U (NMU) activates two G protein-coupled receptors, NMUR1 and NMUR2; this signaling not only controls many physiological responses but also promotes tumorigenesis in diverse tissues. We recently identified a novel truncated NMUR2 derived by alternative splicing, namely NMUR2S, from human ovarian cancer cDNA. Sequence analysis, cell surface ELISA immunocytochemical staining using 293T cells indicated that NMUR2S can be expressed well on the as six-transmembrane protein. Receptor...
Gprotein-coupled receptors (GPCRs) regulate several physiological and pathological processes represent the target of approximately 30% Food Drug Administration-approved drugs. GPCR-mediated signaling was thought to occur exclusively at plasma membrane. However, recent studies have unveiled their presence function subcellular membrane compartments. There is a growing interest in studying compartmentalized GPCRs. This requires development tools separate GPCR from ones initiated intracellular...
Neuromedin U (NMU) was originally identified as an anorexigenic peptide that modulates appetite well energy homeostasis through the brain-gut axis. Although growing evidence has linked NMU activity with development of female reproductive organs, no direct expression and function for in these organs been pinpointed. Using a superovulated rat model, we found is directly expressed ovary, where its transcript level tightly regulated by gonadotropins. Ovarian microdissection immunohistochemical...
Abstract Peritoneal dissemination is the most frequent metastatic route of ovarian cancer. However, due to high heterogeneity in cancer, conventional studies lack parental tumor controls relevant metastases and, thus, it difficult trace molecular changes cancer cells along with selection by abdominal microenvironment. Here, we established an vivo mouse peritoneal scheme that allowed us select more aggressive sublines from cells, including A2780 and SKOV ‐3. Microarray gene profiling analyses...
ABSTRACT G-protein-coupled receptors (GPCRs) regulate several physiological and pathological processes represent the target of approximately 30% FDA-approved drugs. GPCR-mediated signaling was thought to occur exclusively at plasma membrane. However, recent studies have unveiled their presence function subcellular membrane compartments. There is a growing interest in studying compartmentalized GPCRs. This requires development novel tools separate GPCRs from ones initiated intracellular We...
Cannulation in low birth weight (LBW) neonates using larger sheaths could increase the risk of vascular injury. This study investigated relationship between body (BW) and diameter femoral vessels LBW whether BW can be used to predict vessel diameter.The cohort included 100 weighing < 2.5 kg (.57-2.42 kg) with a gestational age 24-39 weeks. Vascular ultrasonography was measure diameters bilateral arteries (FA) veins (FV). The divided into four groups according weight: group-A, 2-2.49 (n =...
Molecular chromophores tend to form crystals beyond nanometer sizes upon thermal aging. A novel ring-protection structure has shown promise solve morphological stability problem of solution-processed small molecule solar cell devices.
Uremic pericarditis and pericardial effusion are possible complications among patients with end-stage renal disease. The accumulation of toxic metabolites may contribute to the pathogenesis uremic pericarditis. Bleeding diathesis in peritoneal dialysis raises risk hemorrhagic tamponade, which is a fatal complication dialysis. We report case tamponade who was nonadherent initial presentation hypotension syncope. Transthoracic echocardiogram revealed septated, fibrinoid right ventricular...
Abstract Cells interpret a variety of signals through G protein-coupled receptors (GPCRs) and stimulate the generation second messengers such as cyclic adenosine monophosphate (cAMP). A long-standing puzzle is deciphering how GPCRs elicit different physiological responses despite generating similar levels cAMP. We previously showed that some generate cAMP from both plasma membrane Golgi apparatus. Here, we demonstrate cardiomyocytes distinguish between subcellular inputs to outputs. show...
Abstract Dopamine is the main catecholamine in brain and kidney, where it controls a number of physiological functions such as locomotion, cognition, emotion, endocrine regulation renal function. As membrane impermeant hormone neurotransmitter, dopamine thought to signal by binding activating receptors, members G protein couple receptor (GPCR) family, only on plasma membrane. Here, using novel nanobody-based biosensors, we demonstrate for first time that D1 (D1DR), primary mediator...