A5051030512- Carbon and Quantum Dots Applications
- Pneumonia and Respiratory Infections
- Respiratory viral infections research
- Streptococcal Infections and Treatments
- Influenza Virus Research Studies
- Advanced Nanomaterials in Catalysis
- Graphene and Nanomaterials Applications
- SARS-CoV-2 and COVID-19 Research
- Viral-associated cancers and disorders
- Curcumin's Biomedical Applications
- Kawasaki Disease and Coronary Complications
- Long-Term Effects of COVID-19
- Nanoplatforms for cancer theranostics
- Pneumothorax, Barotrauma, Emphysema
- Viral gastroenteritis research and epidemiology
- Infectious Encephalopathies and Encephalitis
- Coronary Artery Anomalies
- interferon and immune responses
- COVID-19 epidemiological studies
- Nanoparticles: synthesis and applications
- Vaccine Coverage and Hesitancy
- Cancer-related molecular mechanisms research
- Bacterial Infections and Vaccines
- Pediatric Urology and Nephrology Studies
- Bacterial Identification and Susceptibility Testing
Mackay Memorial Hospital
2015-2024
Mackay Junior College of Medicine, Nursing and Management
2015-2024
Mackay Medical College
2015-2024
Johns Hopkins University
2023
Johns Hopkins Medicine
2023
National Yang Ming Chiao Tung University
2018-2019
University of Arkansas at Little Rock
1984
It is demonstrated that carbon quantum dots derived from curcumin (Cur-CQDs) through one-step dry heating are effective antiviral agents against enterovirus 71 (EV71). The surface properties of Cur-CQDs, as well their activity, highly dependent on the temperature during synthesis. at 180 °C preserves many moieties polymeric surfaces as-synthesized resulting in superior characteristics. proposed undergoes a series structural changes dehydration, polymerization, and carbonization to form...
Abstract Sepsis is a life‐threatening condition that can progress to septic shock as the body's extreme response pathogenesis damages its own vital organs. Staphylococcus aureus ( S. ) accounts for 50% of nosocomial infections, which are clinically treated with antibiotics. However, methicillin‐resistant strains (MRSA) have emerged and withstand harsh antibiotic treatment. To address this problem, curcumin (CCM) employed prepare carbonized polymer dots (CPDs) through mild pyrolysis. Contrary...
Children with tracheostomy are at increased risk for respiratory tract infections, yet the involved in related infections is unclear.We conducted a retrospective review of medical records children who underwent between January 2002 and December 2016 teaching hospital Taipei. Demographics, underlying disease, indication tracheostomy, laboratory data management, long-term outcome were collected. Infection episodes grouped into definite, possible, non-bacterial pneumonia, local infection...
Vascular endothelial growth factor capped gold nanoparticles modified with (11-mercaptoundecyl)-<italic>N</italic>,<italic>N</italic>,<italic>N</italic>-trimethylammonium exhibit superior dual functionality for the treatment of MRSA-infected diabetic wounds.
We have shown in vivo and vitro previously that psychosine causes dysfunction of autophagy the ubiquitin-proteasome system underlying pathogenesis globoid cell leukodystrophy (GLD), a devastating lysosomal storage disease complicated by global demyelination. Here, we investigated therapeutic efficacy mTOR inhibitor rapamycin twitcher mice, murine model infantile GLD, biochemical, histochemical, clinical aspects. Administration to mice inhibited signaling brains, significantly reduced...
Respiratory infections caused by human adenoviruses (HAdV) are worldwide, and have significantly increased recently in Taiwan. This study aimed to clarify the molecular epidemiology risk factors of HAdV severe pneumonia among Taiwanese children.Patients with hospitalized a medical center between 2009 2013 were divided into or nonsevere based on whether not they received intensive care. was identified for comparison. The genotype determined sequencing partial hexon fiber genes. nucleotide...
The aim of this study is to determine the best dosing strategy for vancomycin by studying associated factors and examining correlations between area under plasma concentration-time curve (AUC) values trough concentrations in children.Children aged 3 months 18 years were included if they received more than three doses January 1, 2010 December 31, 2012 had one or serum concentrations. Vancomycin clearance (CL) was calculated using following model: CL = 0.248*Wt0.75*(0.48/serum...
We report a one-pot facile synthesis of highly photoresponsive bovine serum albumin (BSA) templated bismuth-copper sulfide nanocomposites (BSA-BiZ/CuxS NCs, where BiZ represents in situ formed Bi2S3 and bismuth oxysulfides (BOS)). As-formed surface vacancies BiZ/CuxS heterojunctions impart superior catalytic, photodynamic photothermal properties. Upon near-infrared (NIR) irradiation, the BSA-BiZ/CuxS NCs exhibit broad-spectrum antibacterial activity, not only against standard...
Mycoplasma pneumoniae is a common pathogen of respiratory tract infections in pediatric patients. Serological studies are traditional methods for the diagnosis. However, early diagnosis M. remains problematic. We investigate value serum immunoglobulin A (IgA), addition to G (IgG), and M (IgM) levels, children infected with pneumoniae. From August 2016 February 2017, we enrolled patients based on both clinical symptoms chest x-ray, confirmed by positive throat culture Serum titers IgM, IgG,...
Kaposi's sarcoma-associated herpesvirus (KSHV) is the causative agent of sarcoma (KS), an AIDS-defining cancer with abnormal angiogenesis. The high incidence KS in human immunodeficiency virus (HIV)-infected AIDS patients has been ascribed to interaction between HIV type 1 (HIV-1) and KSHV, focusing on secretory proteins. HIV-1 secreted protein Tat found synergize KSHV lytic proteins induce However, impact underlying mechanisms KSHV-infected endothelial cells undergoing viral reactivation...
The isothermal amplification products of<italic>mecA</italic>and<italic>femA</italic>genes induce the fluorescence quenching of platinum ions-capped carbon quantum dots to allow specific identification methicillin-resistant<italic>Staphylococcus aureus</italic>.
Concerns about non-typeable Haemophilus influenzae (NTHi) in otitis media (OM) have grown after the introduction of pneumococcal conjugate vaccine (PCV). We aim to better understand clinical role NTHi pediatric OM. Middle ear fluid samples from children <18 years with OM were obtained 2010 2015. For culture-positive episodes (Streptococcus pneumoniae, H. influenzae, Moraxella catarrhalis, and Streptococcus pyogenes), patients' demographic information reviewed analyzed. A total 783 included...
Campylobacter and Non-typhoidal Salmonella (NTS) are the two most common bacterial pathogens associated with acute gastroenteritis in children. This study aims to elucidate epidemiology of NTS develop a scoring system differentiate them.This retrospective enrolled 886 children ≤18 years age, hospitalized due stool culture-proven or infection from July 2012 December 2015. Pearson's chi-square test multivariate logistic regression were used compare clinical manifestations laboratory data....
Kawasaki disease (KD) is an acute febrile systemic vasculitis of unknown etiology that affects infants and young children. Considerable evidence supports the hypothesis there a genetic basis for KD susceptibility. Genome-wide association studies (GWAS) have identified several variants associated with KD. This study aims to replicate three novel KD-associated single nucleotide polymorphisms (SNPs), by GWAS in Japanese, Taiwanese population. Associations between these SNPs development coronary...
Aminoglycoside-mimicking carbonized polymer dots (CPDs) for bacteremia treatment by blocking the synthesis of bacterial proteins and disrupting membranes.
Background A jaundice-predominant presentation of Kawasaki disease (KD) is atypical. Methods total 12 children with KD a predominant manifestation jaundice at MacKay Children's Hospital were reviewed, along 42 cases reported in the literature since 1990. Results The median age patients was 1.85 years (range: 3 months–4 years), and 66.6% male. All had elevated liver function presentation, 50% hydrops gallbladder, almost 60% gastrointestinal symptoms signs. Complete evident 11 (91.7%), two...
The global impact of COVID-19 has prompted profound shifts in public health policies. epidemiology respiratory infectious disease may change the post-covid era. This study investigates repercussions these policies on diseases, specifically resurgence severe influenza and enterovirus infections post-COVID-19