A5090738753- Diabetes and associated disorders
- Diabetes Management and Research
- T-cell and B-cell Immunology
- Sexual Differentiation and Disorders
- Kawasaki Disease and Coronary Complications
- Immune Cell Function and Interaction
- Pancreatic function and diabetes
- Inflammasome and immune disorders
- Hormonal and reproductive studies
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Protein Tyrosine Phosphatases
- Galectins and Cancer Biology
- Coronary Artery Anomalies
- Pediatric Hepatobiliary Diseases and Treatments
- Thyroid Disorders and Treatments
- Immunodeficiency and Autoimmune Disorders
- Thyroid Cancer Diagnosis and Treatment
- RNA modifications and cancer
- Cervical Cancer and HPV Research
- Diet, Metabolism, and Disease
- Immune Response and Inflammation
- Growth Hormone and Insulin-like Growth Factors
- Streptococcal Infections and Treatments
- Infant Nutrition and Health
- Head and Neck Anomalies
Mackay Memorial Hospital
2014-2023
Taipei Medical University
2013-2023
Mackay Medical College
2013-2023
Memorial Hospital
2015
Pediatrics and Genetics
1998-2010
National Medical Research Center of Dentistry and Maxillofacial Surgery
2003
Autoimmune thyroid disease (AITD), including Graves (GD) and Hashimoto (HD), is an organ-specific autoimmune with a strong genetic component. Although the cytotoxic T-lymphocyte-associated protein 4 (CTLA4) polymorphism has been reported to be associated AITD in adults, few studies have focused on children. The aim of our study was investigate whether CTLA4 polymorphisms, -318C/T (rs5742909), +49A/G (rs231775), CT60 (rs3087243), were GD HD Han Chinese adults We studied 289 adult GD, 265...
Diabetic ketoacidosis (DKA) is associated with dehydration and which can cause acute kidney injury (AKI). The proportion of AKI in children adolescents DKA has not been reported East Asian population. This study aimed to identify the prevalence determine whether there an association between severity recovery time from metabolic acidosis DKA. Medical records (aged <18 years) presenting type 1 or 2 diabetes mellitus 2000-2017 at MacKay Children's Hospital were retrospectively reviewed. was...
Human papillomavirus (HPV) is considered to be a necessary but not sufficient cause for cervical cancer. The host immunogenetic background plays an important role in the persistence of HPV infection and subsequent development Cytotoxic T-lymphocyte antigen-4 ( CTLA-4 ) molecule expressed mainly on activated T cells down-regulation T-cell activation. aim this study was determine if polymorphisms gene are associated with HPV-induced cancer Taiwanese women. Polymerase chain reaction–restriction...
Autoimmune thyroid disease (AITD) is the most common associated autoimmune disorder in type 1 diabetes (T1D). Early detection of AITD crucial to optimize glycemic control, growth, and intellectual development. In this prospective cohort study, we sought characterize prevalence, incident ages risk factors children adolescents with T1D.Patients T1D diagnosed at ≤ 18 years MacKay Children's Hospital, Taipei, from 1990 2019 underwent annual screening for AITD. Institutional Review Board-approved...
Biliary atresia (BA) is a chronic inflammatory disease of the bile ducts resulting in biliary cirrhosis. Vascular endothelial growth factor (VEGF) has been implicated cell-mediated reactions. We aimed to study relationship between genetic variations VEGF gene and susceptibility BA using both case-control family-based methodologies.A total 45 Taiwanese children with BA, 160 ethnically matched healthy controls, 40 families (consisting parents, affected children, unaffected siblings) were...
Kawasaki disease (KD) is a systemic vasculitis caused by unknown infectious agents, host immune dysregulation and genetic susceptibility in children. Coronary artery lesions (CALs) complicate 15-25% of cases untreated KD. The aim this study was to investigate if the single-nucleotide polymorphism (SNP) rs28493229 ITPKC gene associated with KD or CALs Taiwanese A total 385 unrelated children (222 boys 163 girls) were included, 140 whom had CALs. Mean age at diagnosis 1.9 +/- 1.7 (0.1-10.2)...
OBJECTIVE The CTLA4 (cytotoxic T lymphocyte associated antigen‐4) gene encodes the cell receptor involved in control of proliferation and mediates apoptosis. Thus it is a strong candidate for cell‐mediated autoimmune disease. There polymorphism at position 49 exon 1 gene, providing A–G exchange. This reportedly with type diabetes Caucasians but not small data set Chinese. We wished to test this larger more homogeneous Chinese children normal adult controls. DESIGN A population‐based...
Background. Acute suppurative thyroiditis in children is rare and often related to a pyriform sinus fistula or thyroglossal duct remnant, especially when it recurrent. Methods. From January, 1985, through December, 2000, 15 with acute were treated. Their clinical, laboratory radiologic findings reviewed analyzed. Results. There 8 girls 7 boys, mean age at diagnosis of 6.1 ± 2.9 years (range, 1.5 9.8). A thyroid mass was present on the left 13 right 2 (P < 0.05). Fever, neck pain swelling...
Kawasaki disease is a febrile of children complicated with vasculitis the coronary arteries and potential aneurysm formation. It has been recognized worldwide appears to be increasing in frequency. Studies have found that associated major histocompatibility complex (MHC) class I B antigens. The MHC-class-I-chain-related gene A (MICA) located near HLA-B. triplet repeat microsatellite polymorphism transmembrane region. We investigated controls. Seventy (46 boys), age at diagnosis 1.68 ± 1.69...
Congenital adrenal hyperplasia (CAH) is a common autosomal recessive disorder caused mainly by defects in the steroid 21-hydroxylase gene (CYP21) . The defective CYP21 genes CAH fall into one of three categories: (a) small-scale conversions from CYP21P ; (b) spontaneous mutations; and (c) chimeric RCCX modules that include / (1) TNXA/TNXB (2)(3)(4). module chromosome 6p21.3 human MHC class III region composed part RP (serine/threonine nuclear protein kinase) (5), full-complement C4 gene,...
BackgroundThe gonadotropin-releasing hormone (GnRH) stimulation test is the gold standard for confirming activation of hypothalamic–pituitary–gonadal axis in central precocious puberty (CPP). However, it time-consuming and costly. Our aim was to search a simpler diagnostic modality CPP by 1) evaluating performance basal serum luteinizing (LH), 2) constructing practical scoring system, 3) determining optimal single sampling time LH GnRH test.MethodsData girls aged between 3 9 years at test,...
Background: Oral submucous fibrosis (OSF), an insidious, pre‐cancerous, chronic disease that may affect the entire oral cavity and sometimes extend to pharynx has been reported be associated with immune function. The major histocompatibility complex (MHC) class I chain‐related gene A (MICA) is expressed by keratinocytes other epithelial cells, its encoded protein interacts γ/δ T‐cells localized in submucosa. MICA a triplet repeat (GCT) polymorphism transmembrane domain resulting five...
Background: Oral squamous cell carcinoma (OSCC) is one of the leading cancers in most Asian countries. Alterations immune function have been detected OSCC patients. The pro‐inflammatory cytokine tumor necrosis factor‐ α (TNF‐ ) a central mediator response involved wide range immuno‐inflammatory and infectious diseases. Polymorphism TNF‐ gene has intensively studied as potential determinant susceptibility to numerous cancers. Methods: We genotyped 192 patients with 146 healthy case controls...
Abstract Aim: Several different genetic defects have been found to result in the characteristic phenotypic expression of Prader–Willi syndrome (PWS). Methods: We performed a retrospective analysis 67 cases molecularly confirmed PWS diagnosed from January 1980 through July 2006 five medical centres Taiwan. Clinical manifestations were compared between patients with deletion and those maternal uniparental disomy (UPD). Results: Deletion was present 56 (84%), UPD 10 (15%), probable imprinting...
To understand the relationship among glycemic control, self-efficacy in diabetes management, and distress young people with type 2 diabetes, a cross-sectional descriptive study convenience sampling was designed. A total of 60 who had (T2D), 24 (40%) males 36 (60%) females were included. The mean age 17.2 ranged from 10.5 to 24.5 years, they completed Perceived Diabetes Self-Management Scale, Problem Areas Scale their pharmacologic management life adjustment. Glycated hemoglobin (HbA1c)...
We investigated the prevalence of glutamic acid decarboxylase 65 autoantibody (GADA), insulinoma-associated protein 2 (IA2A), and insulin (IAA) in 750 children with type 1 diabetes (T1D) living Taiwan. GADA, IA2A, IAA were measured by radioimmunoassay. The data assessed χ2 test, binary logistic regression, Spearman rank correlation. Of T1D patients, 66.3% had 65.3% 35.7% IAA, 17.2% no autoantibodies. GADA IA2A significantly decreased along duration. positivity either or was 89.4% within...