A5101965829- Second Language Learning and Teaching
- EFL/ESL Teaching and Learning
- International Student and Expatriate Challenges
- Advanced Combustion Engine Technologies
- Climate Change and Health Impacts
- Electric and Hybrid Vehicle Technologies
- Cancer-related Molecular Pathways
- Online and Blended Learning
- Biodiesel Production and Applications
- Second Language Acquisition and Learning
- Acupuncture Treatment Research Studies
- Cultural Heritage Materials Analysis
- Legume Nitrogen Fixing Symbiosis
- Phytochemicals and Antioxidant Activities
- Salmonella and Campylobacter epidemiology
- Ideological and Political Education
- Refrigeration and Air Conditioning Technologies
- Leaf Properties and Growth Measurement
- Ocular Surface and Contact Lens
- Prostate Cancer Treatment and Research
- Educational Methods and Teacher Development
- Advanced Drug Delivery Systems
- Natural Antidiabetic Agents Studies
- Educational Reforms and Innovations
- Advanced Breast Cancer Therapies
Health Commission of Anhui Province
2025
AstraZeneca (United States)
2021-2025
Southwest Forestry University
2024
Affiliated Hospital of Hebei University
2024
Shandong Academy of Agricultural Sciences
2024
Taizhou University
2024
Chuxiong Normal University
2024
SAIC Motor (United Kingdom)
2020-2024
Zhejiang Sci-Tech University
2024
Kala Pharmaceuticals (United States)
2024
Hematopoietic progenitor kinase 1 (HPK1) is a negative regulator of the T cell receptor signaling pathway and therefore target interest for immunooncology. Nonselective HPK1 inhibitors may affect other components activation, blunting beneficial impact enhanced activity that results from inhibition itself. Here, we report discovery pyrazine carboxamide their optimization through structure-based drug design to afford highly selective inhibitor, compound 24 (AZ3246). This induces IL-2 secretion...
Abstract Background New data are accumulating on gut microbial dysbiosis in Parkinson’s disease (PD), while the specific mechanism remains uncharacterized. This study aims to investigate potential role and pathophysiological of microbiota 6-hydroxydopamine (6-OHDA)-induced PD rat models. Methods The shotgun metagenome sequencing fecal samples from patients healthy individuals were obtained Sequence Read Archive (SRA) database. diversity, abundance, functional composition further analyzed...
Cyclocarya paliurus, a novel functional food resource, exhibits significant hypoglycemic and hypolipidemic effects in treating type II diabetes mellitus (T2DM). Flavonoids are the effective medicinal components of C. paliurus; however, their specific mechanisms treatment T2DM need further evaluation. In this study, vitro experiments, transcriptomic analysis, network pharmacology, biolayer interferometry were used to investigate total flavonoids paliurus (CTFs) on beta-TC-6 cells elucidate...
Abstract Cyclin-dependent kinases (CDKs) are an attractive class of cancer targets due to their role in cell-cycle regulation. CDK2 is a Ser/Thr kinase activated via interaction with its cyclin partners CCNE and CCNA, driving G1/S progression the cell cycle. inhibition has potential address multiple resistance mechanisms CDK4/6 inhibitors breast cancer. In addition, CCNE1 frequently amplified over-expressed cancers including ovarian, pre-clinical data linking sensitivity high CCNE1....
Abstract Cyclin-dependent Kinase 2 (CDK2) is a Ser/Thr kinase activated via interaction with its cyclin partners CCNE and CCNA, driving G1/S progression of the cell cycle. CDK2 inhibition has potential to address multiple resistance mechanisms CDK4/6 inhibitors in breast cancer. In addition, CCNE1 frequently amplified over-expressed cancers including ovarian, uterine, breast, gastric others, pre-clinical data linking sensitivity high CCNE1. The inhibitor field historically suffered from...
Biochar application is considered an effective method for reducing nitrous oxide (N2O) emissions from soil. However, the mechanisms underlying influence of various biochar dosages on soil N2O and duration one-time remain unclear. The effects different rates a in Huanghuaihai Plain China were investigated through field experiment 2020 to 2022. In wheat maize rotation system, six treatments administered: no (C0); 2 (C1), 4 (C2), 8 (C3), 12 t/hm2 (C4) applied annually; (CS) 2018. Our results...
Soil is the basis of existence fruit tree and soil nutrients plays a crucial role in plant growth berry quality. To investigate characteristics interrelationships between quality Cabernet Gernischet vineyards, this study focused on seven representative vineyards eastern foothills Helan Mountains. Fifteen physicochemical factors 10 were measured, followed by variation analysis, correlation multiple linear regression (MLR), partial-least squares (PLSR), principal component analysis (PCA),...
Abstract As one of the pioneering nations to heed Food and Agriculture Organization (FOA) initiative, China has implemented a comprehensive evaluation protection framework for China’s Nationally Important Agricultural Heritage Systems (CNIAHS). This research concentrated on 188 CNIAHS sites, utilizing methodologies including spatial information entropy, kernel density estimation hotspot analysis scrutinize configurations evolutionary trajectories throughout six historical epochs; combined...
Splash erosion is an important soil process in sloping lands. This study aims to improve the model of rain splash transport based on results previous studies and field experiments involving rainfall simulation. A was conducted examine effects properties, herbaceous cover surface flow processes hillslopes northern China. On basis experimental results, a comprehensive established through quantitative analysis interactive kinetic energy, vegetation coverage overland runoff depth rate...
Abstract Background Several studies showed that androgen deprivation therapy (ADT) plus local treatment of prostate could improve metastatic cancer (mPCa) patients’ survival. To date there are few analyzed the value cryoablation in mPCa. The objective our analysis is to evaluate oncological results and clinical combined with ADT compared alone newly diagnosed mPCa patients. Methods Newly patients undergoing (group A) between January 2011 November 2018 were identified. Patients receiving B)...
This paper explores the significant influence of cultural factors on learning styles and their implications for educational practice. As classrooms become increasingly diverse, understanding interplay between culture preferences is essential fostering inclusive environments. Cultural factors, such as communication styles, student-teacher relationships, parental involvement, significantly impact how students engage with content. Recogizing these influences enables educators to adapt teaching...
<div class="section abstract"><div class="htmlview paragraph">The high-efficiency dedicated hybrid engine (DHE) has led to increasingly complex challenges in thermal management. On one hand, the high compression ratio of up 16:1 makes more susceptible knocking, necessitating meticulous management mitigate potential sensitivity metal temperature. other extensive use external cooled exhaust gas recirculation (EGR) helps reduce knocking and improve efficiency, but it also raises...
To observe the effects of acupuncture combined with bloodletting on expression inflammatory factors in serum, morphology sensitized skin tissue and mast cell degranulation urticaria rats, to explore potential mechanism this therapy for urticaria.
Abstract Antioxidant defense enzymes are important components in induced responses of plants. Activities the antioxidant enzymes, superoxide dismutase (SOD), catalase (CAT), and peroxidase (POD) Larix gmelinii Rupr. seedlings stressed by needle cutting or feeding Dendrolimus superans Butler larvae (Lepidoptera: Lasiocampidae) were compared. Both needles larval increased enzyme activities. The maximum activities two treatments appeared after similar time lags following feeding, but intensity...