A5028576202- Fungal and yeast genetics research
- Microbial Metabolic Engineering and Bioproduction
- Biofuel production and bioconversion
- Fermentation and Sensory Analysis
- Distributed systems and fault tolerance
- Advanced Software Engineering Methodologies
- Gut microbiota and health
- Gastrointestinal motility and disorders
- Clostridium difficile and Clostridium perfringens research
- Mobile Agent-Based Network Management
- Plant Stress Responses and Tolerance
- Academic Research in Diverse Fields
- Health Systems, Economic Evaluations, Quality of Life
- Bioinformatics and Genomic Networks
- Antifungal resistance and susceptibility
- Modular Robots and Swarm Intelligence
- Biomedical Ethics and Regulation
- Model-Driven Software Engineering Techniques
- Endoplasmic Reticulum Stress and Disease
- Pharmaceutical Economics and Policy
- Healthcare during COVID-19 Pandemic
- Business Process Modeling and Analysis
- CRISPR and Genetic Engineering
- Distributed and Parallel Computing Systems
- Fire effects on ecosystems
Bruegel
2025
Institute for Biotechnology and Bioengineering
2017-2024
University of Lisbon
1999-2024
Instituto Politécnico de Lisboa
2021-2024
University of Coimbra
2019
Institute for Systems Engineering and Computers
2019
Instituto de Engenharia de Sistemas e Computadores Investigação e Desenvolvimento
1999-2002
Abstract The YEASTRACT+ information system (http://YEASTRACT-PLUS.org/) is a wide-scope tool for the analysis and prediction of transcription regulatory associations at gene genomic levels in yeasts biotechnological or human health relevance. new portal that integrates previously existing YEASTRACT (http://www.yeastract.com/) PathoYeastract (http://pathoyeastract.org/) databases introduces NCYeastract (Non-Conventional Yeastract) database (http://ncyeastract.org/), focused on so-called...
The YEAst Search for Transcriptional Regulators And Consensus Tracking (YEASTRACT-www.yeastract.com) information system has been, 11 years, a key tool the analysis and prediction of transcription regulatory associations at gene genomic levels in Saccharomyces cerevisiae. Since its last update June 2017, YEASTRACT includes approximately 163000 between factors (TF) target genes S. cerevisiae, based on more than 1600 bibliographic references; it also 247 specific DNA binding consensus...
Abstract YEASTRACT+ (http://yeastract-plus.org/) is a tool for the analysis, prediction and modelling of transcription regulatory data at gene genomic levels in yeasts. It incorporates three integrated databases: YEASTRACT (http://yeastract-plus.org/yeastract/), PathoYeastract (http://yeastract-plus.org/pathoyeastract/) NCYeastract (http://yeastract-plus.org/ncyeastract/), focused on Saccharomyces cerevisiae, pathogenic yeasts Candida genus, non-conventional biotechnological relevance. In...
Abstract Background The red oleaginous yeast Rhodotorula toruloides is a promising cell factory to produce microbial oils and carotenoids from lignocellulosic hydrolysates (LCH). A multi-stress tolerant strain towards four major inhibitory compounds present in LCH methanol, was derived our laboratory IST536 (PYCC 5615) through adaptive evolution (ALE) under methanol high glycerol selective pressure. Results Comparative genomic analysis suggested the reduction of original ploidy triploid...
Abstract The human intestinal microbiota plays a crucial role in health and disease, yet recreating its complex interactions vitro remains significant challenge. Gut 3 Gel introduced herein as novel mucus model, designed for culturing microbial communities without the need anaerobic conditions. Intestinal samples from five donors were individually inoculated cultured 72 hours. Taxonomic composition assessment revealed that sustains diverse species particularly promotes growth of...
<title>Abstract</title> Background The human intestinal microbiota plays a crucial role in health and disease, yet recreating its complex interactions <italic>in vitro</italic> remains significant challenge. Gut<sup>3</sup>Gel introduced herein as novel mucus model, designed for culturing microbial communities without the need anaerobic conditions. Results Intestinal samples from five donors were individually inoculated cultured 72 hours. Taxonomic composition assessment revealed that...
The non-conventional yeast species Zygosaccharomyces bailii is remarkably tolerant to acetic acid, a highly important microbial inhibitory compound in Food Industry and Biotechnology. ZbHaa1 the functional homologue of S. cerevisiae Haa1 bifunctional transcription factor able modulate Z. adaptive response acid copper stress. In this study, RNA-Seq was used investigate genomic changes during early sublethal concentrations (140 mM, pH 4.0) or (0.08 mM) uncover regulatory network activated by...
This article introduces a novel low-cost smart system of networked nodes, based narrow beam Far Infrared (FIR) sensors, which can detect and locate strong heat sources, such as fire, in real-time. is able to approaching wildfires, be used combination with active fire protection mechanisms, water sprinklers, order attempt sustain the advance flame front. The prime objective this work was develop solution proactively protect small areas interest: isolated homes, villages, camping sites, music...
Acetic acid-induced stress is a common challenge in natural environments and industrial bioprocesses, significantly affecting the growth metabolic performance of Saccharomyces cerevisiae. The adaptive response tolerance to this involves activation complex network molecular pathways. This study aims delve deeper into these mechanisms S. cerevisiae, particularly focusing on role Hrk1 kinase. key determinant acetic acid tolerance, belonging NPR/Hal family, whose members are implicated...
Abstract Numerous genomes are sequenced and made available to the community through NCBI portal. However, and, unlike what happens for gene function annotation, annotation of promoter sequences underlying prediction regulatory associations is mostly unavailable, severely limiting ability interpret genome in a functional genomics perspective. Here we present an approach where one can download interest from GenBank Flat File (.gbff) format with minimum set commands, have all information...
The oleaginous yeast species Rhodotorula toruloides is a promising candidate for applications in circular bioeconomy due to its ability efficiently utilize diverse carbon sources being tolerant cellular stress bioprocessing. Previous studies including genome-wide analyses of the multi-stress strain IST536 MM15, derived through adaptive laboratory evolution from lipid production sugar beet hydrolysates, suggested occurrence significant modifications cell wall. In this study, wall integrity...
Developing multiuser virtual environments (MUVE) is a very complex task since it involves several engineering domain aspects such as reality, cooperative work and distributed systems. Furthermore, existing technologies like graphics capabilities, processing power network bandwidth, are permanently evolving. For MUVE systems to be successfully developed, they must not only deal with all the different that inherent these but also have ability continuous technology requirements evolution. To...
Replication and distributed communication are usually tightly coupled. This code tangling forbids their independent reuse adaptation. In this position paper, the problems resulting from coupling replication with discussed. addition, a solution based on separation of concerns is proposed. The abstractions for each concern presented, as well composition.
Problems underlying the question of clinical evidence in medical device performance have been subject of critical review several reference journals field. And yet, demand for higher methodological studies is increasing, considering that they will determine, on a first phase, market authorization and, second its adoption within health system scheme based on its added therapeutic value comparison with alternative methods, core component the Health Technology Assessment process.This paper tries...