A5047867288- Spine and Intervertebral Disc Pathology
- Musculoskeletal pain and rehabilitation
- Cystic Fibrosis Research Advances
- Gut microbiota and health
- Gastrointestinal motility and disorders
- Bacterial biofilms and quorum sensing
- Clostridium difficile and Clostridium perfringens research
- Electrospun Nanofibers in Biomedical Applications
- Infectious Aortic and Vascular Conditions
- Pain Management and Treatment
- Bone Tissue Engineering Materials
- Pelvic and Acetabular Injuries
- Neonatal Respiratory Health Research
- Tendon Structure and Treatment
- Orthopaedic implants and arthroplasty
- Cervical and Thoracic Myelopathy
- Silk-based biomaterials and applications
- Inhalation and Respiratory Drug Delivery
- 3D Printing in Biomedical Research
- Polymer Surface Interaction Studies
Bruegel
2025
Politecnico di Milano
2017-2023
National Interuniversity Consortium of Materials Science and Technology
2020
Bioengineering Technology and Systems (Italy)
2018
University of Minho
2015-2017
Degeneration of the intervertebral disc (IVD) represents a significant musculoskeletal disease burden. Tissue engineering has proposed several strategies comprising use biodegradable materials to prepare scaffolds that can present mechanical properties similar those native IVD tissues. However, this might be insufficient, since patient's space geometry must replicated allow for appropriate implant fixation and integration. Herein, we propose reverse rapid prototyping techniques with goal...
Abstract The human intestinal microbiota plays a crucial role in health and disease, yet recreating its complex interactions vitro remains significant challenge. Gut 3 Gel introduced herein as novel mucus model, designed for culturing microbial communities without the need anaerobic conditions. Intestinal samples from five donors were individually inoculated cultured 72 hours. Taxonomic composition assessment revealed that sustains diverse species particularly promotes growth of...
<title>Abstract</title> Background The human intestinal microbiota plays a crucial role in health and disease, yet recreating its complex interactions <italic>in vitro</italic> remains significant challenge. Gut<sup>3</sup>Gel introduced herein as novel mucus model, designed for culturing microbial communities without the need anaerobic conditions. Results Intestinal samples from five donors were individually inoculated cultured 72 hours. Taxonomic composition assessment revealed that...
Clinically available alternatives of vascular access for long-term haemodialysis-currently limited to native arteriovenous fistulae and synthetic grafts-suffer from several drawbacks are associated high failure rates. Bioprosthetic grafts tissue-engineered blood vessels costly without clearly demonstrated increased performance. In situ tissue engineering could be the ideal approach provide a that profits advantages in short-term (e.g. early cannulation) success rates driven by...
Abstract Several attempts made so far to combine silk fibroin and polyurethane, in order prepare scaffolds encompassing the bioactivity of former with elasticity latter, suffer from critical drawbacks concerning industrial clinical applicability (e.g., separation phases upon processing, use solvents unaddressed by European Pharmacopoeia, degradable polyurethanes). Overcoming these limitations, this study, we report successful blending regenerated a medical‐grade, non‐degradable polyurethane...
Abstract The intrinsic heterogeneity of bacterial niches should be retained in vitro cultures to represent the complex microbial ecology. As a case study, mucin‐containing hydrogels ‐CF‐Mu 3 Gel ‐ are generated by diffusion‐induced gelation, bioinspired on cystic fibrosis (CF) mucus, and niche challenging current therapeutic strategies. At breathing frequency, CF‐Mu exhibits G ′ ″ equal 24 3.2 Pa, respectively. Notably, structural gradients with gradual reduction oxygen tension across its...
Abstract A distinctive feature of the biological substrates hosting bacterial niches is their intrinsic heterogeneity, which should be retained in vitro cultures to closely represent complex microbial ecology. Here, we design and characterise 3D providing bacteria with environments that possess structural heterogeneity spontaneous microscopic dynamics. As a case study, generate by diffusion-induced gelation mucin-based hydrogel (CF-Mu 3 Gel) bioinspired on cystic fibrosis (CF) mucus, niche...