A5101510847- Cardiac Structural Anomalies and Repair
- Aortic Disease and Treatment Approaches
- Cardiac Valve Diseases and Treatments
- Cancer-related molecular mechanisms research
- Congenital Heart Disease Studies
- RNA modifications and cancer
- Aortic aneurysm repair treatments
- MicroRNA in disease regulation
- Cardiac and Coronary Surgery Techniques
- Inflammasome and immune disorders
- Circular RNAs in diseases
- Cardiac tumors and thrombi
- interferon and immune responses
- Anesthesia and Neurotoxicity Research
- Cardiomyopathy and Myosin Studies
- Medical Imaging and Pathology Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Personality Disorders and Psychopathology
- Cardiovascular and Diving-Related Complications
- Cardiac Health and Mental Health
- Mechanical stress and fatigue analysis
- Venous Thromboembolism Diagnosis and Management
- Cardiac Ischemia and Reperfusion
- Psychotherapy Techniques and Applications
- Neonatal Respiratory Health Research
First Affiliated Hospital of Anhui Medical University
2015-2025
Anhui Medical University
2014-2024
Guilin University of Electronic Technology
2024
Qingdao University
2022
Second Hospital of Anhui Medical University
2018
China Medical University
2012
Beijing Polytechnic
2002
Beijing University of Technology
2002
Abstract Many studies have shown that long-noncoding RNA (lncRNA) is associated with cardiovascular disease, but its molecular mechanism still unclear. In this study, we explored the role of lncRNA ANRIL in ox-LDL-induced phenotypic transition human aortic smooth muscle cells (HASMC). The results quantitative fluorescence PCR showed expression patients coronary atherosclerotic heart disease (CAD) was significantly higher than normal subjects. RNA-FISH detection increased HASMC treated by...
Live streaming with goods is developing rapidly as an emerging platform economic model. Consumers can interact the e-commerce in real-time and get a good shopping experience. This turn generates value co-creation behaviors such word-of-mouth communication. However, due to lack of effective audit mechanisms on some platforms, phenomenon co-destruction among them becoming more common. brings loss consumers, other multiple subjects. Based SOR model, this paper collects 212 sample data by using...
IMPORTANCE Postoperative delirium is a common and impactful neuropsychiatric complication in patients undergoing coronary artery bypass grafting surgery. Cognitive training may enhance cognitive reserve, thereby reducing postoperative delirium. OBJECTIVE To determine whether preoperative reduces the incidence of grafting. DESIGN, SETTING, PARTICIPANTS This prospective, single-blind, randomized clinical trial was conducted at 3 university teaching hospitals southeastern China with enrollment...
The cyclic guanosine monophosphate (GMP)-adenosine (AMP) synthase-stimulator of interferon genes (cGAS-STING) signaling pathway, an important component the innate immune system, is involved in development several diseases. Ectopic DNA-induced inflammatory responses are pathological processes. Repeated damage to tissues and metabolic organelles releases a large number damage-associated molecular patterns (mitochondrial DNA, nuclear exogenous DNA). DNA fragments released into cytoplasm sensed...
Abstract The aim of the present study was to explore role long non-coding RNA (lncRNA) repressor NFAT (NRON) in atrial fibrosis and whether its underlying mechanism associated with macrophage polarization. Enzyme-linked immunosorbent assay (ELISA) analysis pro-inflammatory cytokines revealed that NRON overexpression suppressed, whereas silencing facilitated angiotensin II (Ang II)-induced inflammatory response primary cultured myocytes. chromatin immunoprecipitation (ChIP) results showed...
Objective To ascertain if levosimendan postconditioning can alleviate lung ischemia–reperfusion injury (LIRI) in rats. Method One hundred rats were divided into five groups: Sham (sham), group (I/R group), ischemic (IPO (Levo group) and combination of 5-Hydroxydecanoic acid (Levo+5-HD group). The apoptotic index (AI) tissue cells was determined using the terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay. Expression active cysteine aspartate specific protease-3 (...
Smoking is an important factor in the pathogenesis of chronic obstructive pulmonary disease (COPD), which commonly characterised by cellular senescence and inflammation. Recently, miR-200b has emerged as target to cure lung disease; however, function reducing inflammatory responses not been reported. In this study, we found that was downregulated lungs COPD model mice, its expression correlated with responses. We hypothesised may be a potential novel therapy for treating COPD. performed...
Atherosclerosis (AS) is a chronic progressive disease caused by injury and functional changes in vascular smooth muscle cells (VSMCs). Long non‑coding RNAs (lncRNAs) are pivotal regulators AS development. The present study aimed to explore the roles molecular mechanisms of lncRNA CTBP1‑AS2 progression. A dual‑luciferase reporter assay confirmed that miR‑195‑5p downstream target miRNA was increased AS. expression levels serums patients with human aorta or decreased, respectively, following...
Abstract Objective To investigate the independent risk factors for postoperative prolonged ICU stay in patients with Stanford type A aortic dissection (TAAD) and assess clinical outcomes of stay. Method The data 100 TAAD admitted to Department Cardiovascular Surgery, First Affiliated Hospital Anhui Medical University from December 2018 September 2022 were retrospectively collected analyzed. Patients divided into two groups, based on (7 days as threshold), regular group (< 7 days) (≥...
Abstract Aims Long non-coding RNA (LncRNA) small nucleolar host gene 18 (SNHG18) has been widely implicated in cancers. However, little is known about its functional involvement vascular diseases. Herein, we attempted to explore a role for SNHG18 modulating smooth muscle cell (VSMC) contractile phenotype and injury-induced neointima formation. Methods results Analysis of single-cell sequencing transcriptomic datasets showed decreased levels injured atherosclerotic murine human arteries,...
Atrial apoptosis has been found to be majorly involved in the pathogenesis of human atrial fibrillation (AF). Mesencephalic astrocyte-derived neurotrophic factor exerts an antiapoptotic effect for multiple cell types. However, correlation between MANF and AF is still undefined. In this study, 59 patients with valvular or congenital heart disease were divided into 2 groups: group sinus rhythm (SR) group. We that apoptotic myocytes right appendage tissues significantly more than those SR...
Background: We aimed to report the experience of robotic-assisted cardiac surgery (RACS) using Da Vinci robotic surgical system, meanwhile its efficacy and safety was also evaluated by comparing with traditional open-heart (TOHS), thus provide evidence for a broader application RACS in clinical practice.
Cardiac myxomas are commonly located in the left atrium but rarely affect right side of heart. We retrospectively analyzed 28 patients receiving surgical treatment for heart at our center and aimed to summarize clinical features outcomes myxomas.Between May 2001 June 2022, 244 with sporadic cardiac underwent complete resection. Twenty-eight (28/244, 11.48%) were myxomas. Among myxoma cases, 25 median sternotomy 3 robotic or total thoracoscopic procedures. The features, operative information,...
We speculated that ubiquitin specific peptidase 4 (USP4) may deubiquitinate interferon regulatory factor (IRF4) and affect T helper type 2 (Th2) cell function. This study aimed to validate this hypothesis. Here, the interaction between USP4 IRF4 were analyzed by co-immunoprecipitation assay. The deubiquitin effect of on was Ni-NTA pull down Luciferase reporter gene constructs used analyze effects USP4, nuclear activated cell-2 (NFATc2) activation interleukin-4 (IL-4) promoter. Then, Th2...
Atherosclerosis is an inflammatory disease; monocytes and macrophages play important role in the progression of this disease. However, mechanisms are not fully understood yet. Nicotinamide phosphate transferase (NAMPT) rate limiting enzyme synthesis NAD, but extracellular NAMPT shows characteristics cytokines/adipokines, suggesting that it may be a link between metabolism inflammation. In study, we compared expression levels NAMPT/NAD+/Sirt1 signaling pathway as well NAMPT, CRP IL-6...
Intravenous leiomyomatosis (IVL) is a rare form of gynaecological- uterine leiomyoma. Clinically, the diagnosis and treatment are more difficult challenging due to occult symptoms clinical presentations, which can be similar other common diseases. In this report, comprehensive management case IVL reported discussed, with aim sharing our academic experience improve medical IVL.
Abstract Advances in instrumentation and technique have facilitated minimally invasive surgeries for cardiac myxoma treatment. This study aims to compare the clinical outcomes between thoracoscopic robotic approaches resection. Intraoperative data postoperative of 46 patients who underwent either ( n = 15) or 31) resection our center July 2013 September 2022 were retrospectively compared. There was no in-hospital death group. Meanwhile, operative time cardiopulmonary bypass significantly...
Minimally invasive surgery has emerged as a favorable alternative to conventional for various cardiac conditions. This study aimed compare the perioperative outcomes and follow-up results of robotic approach versus sternotomy left atrial myxoma (LAM) resection. We retrospectively analyzed 94 patients who underwent resection using either (n = 64) or 30) at our center between January 2017 April 2023. Multiple linear regressions were employed examine actual impact surgical on while controlling...
Aortic dissection (AD) is a lethal aortic pathology without effective medical treatments since the underlying pathological mechanisms responsible for AD remain elusive. Matrix metalloproteinase-8 (MMP8) has been previously identified as key player in atherosclerosis and arterial remodeling. However, functional role of MMP8 remains largely unknown. Here, we report that an increased level was observed 3-aminopropionitrile fumarate (BAPN)-induced murine AD. incidence elastin fragmentation were...