A5046783629- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Glaucoma and retinal disorders
- Retinal and Optic Conditions
- Retinal Development and Disorders
- Cancer, Hypoxia, and Metabolism
- Diabetes Management and Research
- Multiple Sclerosis Research Studies
- Systemic Lupus Erythematosus Research
- Ocular Oncology and Treatments
- Cerebral Venous Sinus Thrombosis
- Laser Applications in Dentistry and Medicine
- Ocular Diseases and Behçet’s Syndrome
- Immune cells in cancer
- interferon and immune responses
- melanin and skin pigmentation
- Retinal and Macular Surgery
University of Padua
2016-2024
Azienda Ospedaliera di Padova
2022
Abstract Purpose To evaluate changes of specific retinal imaging biomarkers [intraretinal hyper‐reflective spots: HRS ; subfoveal neuroretinal detachment: SND and increased foveal autofluorescence: IFAF after intravitreal steroid or anti‐vascular endothelial growth factor treatment in diabetic macular oedema ( DME )] as possible indicators inflammatory condition. Methods Retrospective analysis images clinical charts 49 eyes (49 patients) with treated dexamethasone (dexamethasone, 23 eyes)...
To evaluate hyperreflective retinal spots (HRS), in normal subjects and diabetic patients without with macular edema (diabetic edema, DME), on linear B-scans corresponding en face image of spectral-domain optical coherence tomography.Retrospective evaluation images 54 eyes/subjects (16 subjects, 19 DME, DME). On horizontal B-scan tomography, passing through the center fovea, following characteristics HRS were evaluated: location (inner retina or outer retina), size (≤30 >30 μm), reflectivity...
Artificial intelligence (AI) and deep learning (DL)-based systems have gained wide interest in macular disorders, including diabetic edema (DME). This paper aims to validate an AI algorithm for identifying quantifying different major optical coherence tomography (OCT) biomarkers DME eyes by comparing the human expert manual examination. Intraretinal (IRF) subretinal fluid (SRF) detection volumes, external limiting-membrane (ELM) ellipsoid zone (EZ) integrity, hyperreflective retina foci...
Optical coherence tomography (OCT) allows us to identify, into retinal layers, new morphological entities, which can be considered clinical biomarkers of diseases. According the literature, solitary, small (<30 µm), medium level hyperreflective (similar fiber layer) foci (HRF) may represent aggregates activated microglial cells and an in vivo biomarker inflammation. The identification quantification this imaging for estimating possibly amount intraretinal inflammation major...
The disorganization of retinal inner layers (DRIL) is an optical coherence tomography (OCT) biomarker strictly associated with visual outcomes in patients diabetic macular edema (DME) whose pathophysiology still unclear. aim this study was to characterize vivo, using imaging and liquid biopsy, DRIL eyes DME. This observational cross-sectional study. Patients affected by center-involved DME were enrolled. All underwent spectral domain (SD-OCT) proteomic analysis aqueous humor (AH). presence...
To evaluate, by means of optical coherence tomography (OCT) and OCT angiography (OCTA), early retinal, choroidal macular perfusion changes induced a local inflammatory reaction secondary to uncomplicated cataract surgery.Selected eyes undergoing surgery were enrolled in prospective study. OCTA performed before (T0) at day: 1 (T1), 7 (T7), 30 (T30) 90 (T90). Inner (IR) outer retinal (OR) volumes, volume, hyper-reflective spots (HRS) IR OR measured OCT. Macular was analysed superficial (SCP),...
Background Increasing evidence suggests that retinal hyper-reflecting foci (HRF) might be clusters of activated and proliferating microglia. Since microglia are widespread in multiple sclerosis (MS) brain, its evaluation retina may help to understand monitor MS-related pathology. Aim This study aims at investigating the association HRF with cerebrospinal fluid (CSF) cytokines MRI parameters relapsing–remitting MS (RRMS). Methods Nineteen RRMS clinical onset 15 non-inflammatory neurological...
The aim of this study was to evaluate the long-term efficacy and safety 577-nm subthreshold micropulse laser (SMPL) treatment in a large population patients affected by mild diabetic macular edema (DME) real-life setting. We retrospectively evaluated 134 eyes previously untreated center-involving DME, treated with SMPL, using fixed parameters. Retreatment performed at 3 months, case persistent retinal thickening. Optical coherence tomography (OCT), along short near-infrared fundus...
<h3>Background and Objectives</h3> Microglia, the resident immune cell of brain retina, is widespread activated in white gray matter (GM) multiple sclerosis (MS). The objective this study to evaluate presence number hyperreflecting foci (HRF), considered clusters proliferating retinal microglia, their association with clinical radiologic disease parameters relapsing-remitting MS (RRMS). <h3>Methods</h3> At baseline, 80 patients RRMS underwent optical coherence tomography (OCT) 3T-MRI...
Background: To evaluate the earliest retinal morphological and functional changes in diabetic eyes without or with early signs of retinopathy (DR). Methods: Twenty-two no DR (noDR group), 22 mild (DR 18 healthy nondiabetic (controls) were enrolled. All studied by means spectral domain optical coherence tomography (OCT), OCT angiography (OCTA), multifocal electroretinogram (mfERG). Results: A significantly higher number hyperreflective intraretinal foci (HRF) was found both noDR groups versus...
To analyze the early microvascular retinal changes and oscillatory potentials alterations secondary to diabetic damage, 44 eyes of 22 patients without with mild retinopathy (DR) 18 9 healthy controls were examined. All subjects underwent spectral domain optical coherence tomography (SD-OCT), OCT angiography (OCTA), electroretinography (OPs). At OCTA, vessel area density (VAD), length fraction (VLF), fractal dimension (FD) significantly reduced in superficial vascular plexus (SVP), VLF FD...
The aim of the study was to validate performance Optomed Aurora® handheld fundus camera in diabetic retinopathy (DR) screening. Patients who were affected by diabetes mellitus and referred local DR screening service underwent photography using a standard table-top camera. All photos taken single, previously unexperienced operator. Among 423 enrolled eyes, we found prevalence 3.55% 3.31% referable cases with camera, respectively. obtained sensitivity 96.9% specificity 94.8% recognizing...
von Hippel-Lindau (VHL) disease is caused by a mutation of the VHL gene and characterized development retinal hemangioblastomas (RH). Current pathophysiologic mechanisms RH progression are still insufficient to predict behavior. involved in cellular response hypoxia many intracellular signaling pathways expressed both angiogenesis inflammation. Optical coherence tomography (OCT) allows identify hyper-reflective foci (HRF) known as aggregates activated microglial cells possible vivo biomarker...
Purpose To analyze the individual value and contribution of color fundus photography (CFP) optical coherence tomography (OCT) in screening age-related macular degeneration (AMD) an unselected population. Methods CFP OCT images 15957 eyes 8069 subjects older than 55 years, obtained during a population-based for AMD using single diagnostic non-mydriatic imaging device, were analyzed by blinded examiner. The two techniques preliminary evaluated considering dichotomous parameter...
The purpose of this study was to evaluate retinal changes in adolescents with childhood-onset, long-lasting type 1 diabetes mellitus (T1D). Patients and healthy controls (HC) underwent optical coherence tomography (OCT) OCT-angiography (OCTA). Individual macular layers, peripapillary nerve fiber layer (pRNFL), vascular parameters (vessel area density (VAD), vessel length fraction (VLF) diameter index (VDI)) superficial (SVP), intermediate (ICP), deep (DCP) radial capillary plexuses (RPCP)...
To analyze the concentration of aqueous humor (AH) cytokines in eyes with idiopathic epiretinal membrane (iERM) and to investigate their potential correlation disease severity.
This study aimed to assess outer retinal layer (ORL), pigment epithelium (RPE), choroid (Ch) and choriocapillaris (CC) modifications in adolescents with long-lasting (>10 years) type 1 diabetes (T1D) without (noDR) or diabetic retinopathy (DR). ORL RPE thickness were measured at optical coherence tomography (OCT) macular scans. Vascular parameters of Ch CC quantified after elaboration OCT-angiography (OCTA) images. Insulin dose auxological metabolic correlated OCT OCTA findings patients....
Background: Von Hippel–Lindau (VHL) disease is a neoplastic syndrome caused by mutation of the VHL tumor suppressor gene. Retinal hemangioblastoma (RH) vascularized and represents most common ocular manifestation this disease. At retinal level, protein able to regulate growth, angiogenic factors, neuroinflammation, probably stimulating glial cells. The aim present study was analyze in vivo optical coherence tomography (OCT) biomarkers macroglia microglia cohort patients. Methods: mean...