Access to quinazolines: The selective amination of C(sp3)H bonds adjacent nitrogen or oxygen atoms N-alkylamides, ethers, alcohols with ortho-carbonyl-substituted anilines constitutes the first step in a tandem annulation that leads quinazolines good excellent yields (see scheme; NIS=N-Iodosuccinimide, TBHP=tert-butyl hydroperoxide). selectivity primary and secondary CH is also noteworthy (left: >3:1, right: >99:1). Detailed facts importance specialist readers are published as "Supporting...

An electrochemically regioselective C–H phosphorothiolation of (hetero)arenes with thiocyanate as the S source under ultrasonic irradiation has been developed. The synergistic cooperation electrooxidation and ultrasonication markedly accelerated reaction. This mechanistically different method is distinguished by its wide substrate scope transition-metal-free external-oxidant-free conditions, thus complementing existing metal-catalyzed or peroxide-mediated protocols for green synthesis...

A regioselective oxidative C-H thio/selenocyanation of arenes and heteroarenes with TMSCN elemental sulfur/selenium was demonstrated under catalyst-free additive-free conditions. Dimethyl sulfoxide (DMSO) employed as the mild oxidant well solvent. The reaction is operationally simple scalable a broad substrate scope.

A copper-promoted cascade reaction of 2-methylazaarenes and benzylamines has been developed via sequential double oxidative C(sp3)–H aminations. This protocol provides straightforward access to imidazo[1,5-a]quinoline derivatives without employing prefunctionalized substrates.

A method for synthesizing indolo‐fused 3‐sulfenylpyrazolo[1,5‐a]pyrimidines has been developed through a one‐pot, iodine‐mediated domino reaction using indole‐3‐carbaldehydes, 3‐aminopyrazoles and dichalcogenides or thiophenols. Mechanistic studies suggest that the proceeds radical pathway during C‐S bond formation, with an iodonium ion intermediate driving cyclization step. Additionally, some products exhibit significant antitumor activity.

A general and practical route to the synthesis of multisubstituted pyrrolo[1,2-a]quinolines has been described from 2-alkylazaarenes nitroolefins using cerium chloride as a catalyst via tandem Michael addition, cyclization aromatization. This protocol features readily available starting materials, operational simplicity high regioselectivity access multifunctionalized with formation multiple C-C C-N bonds in one pot. In various substitution patterns functional groups were found be compatible...

An iodine-catalyzed regioselective sulfenylation of imidazo[1,5-<italic>a</italic>]quinolines was developed under metal- and oxidant-free reaction conditions.

C-N bonds are widely existed in drugs, natural products, and functional materials.Thus, the construction of is one most important research areas academia industry.Recently, renaissance organic electrochemistry has promoted electrochemical bond formations to be a special branch synthesis.The recent advances since 2015 summarized.The reaction mechanisms these transformations discussed, challenges future directions this filed included.We hope that review can give references researchers,...

Zugang zu Chinazolinen: Die selektive Aminierung der C(sp3)-H-Bindungen neben den Stickstoff- oder Sauerstoffatomen von N-Alkylamiden, Ethern Alkoholen mit ortho-Carbonyl-substituierten Anilinen ist erste Schritt einer Tandemanellierung, die in guten bis exzellenten Ausbeuten Chinazolinen führt (siehe Schema; NIS=N-Iodsuccinimid, TBHP=tert-Butylhydroperoxid). Selektivität primärer und sekundärer C-H-Bindungen ebenfalls bemerkenswert (links: >3:1, rechts: >99:1). Detailed facts of importance...

A cobalt-catalyzed oxidative [3 + 2] cycloaddition cascades of dihydroisoquinoline esters with nitroolefins or N-sulfuryl aldimines were developed at room temperature. multi-component reaction for the synthesis 5,6-dihydroimidazo[2,1-a]isoquinolines also realized under almost identical conditions. This method is particularly suitable tricyclic nitrogen heterocycles due to its simple manipulation, wide scope substrates and excellent regioselectivity.

Abstract The first solvent‐controlled copper‐catalyzed oxidative decarboxylative coupling of alkenyl acids with P(O)H compounds for C(sp 2 )−P bond formation by a free‐radical process is reported. reaction enables the highly chemo‐ and stereoselective synthesis various ( E )‐alkenylphosphonates )‐alkenylphosphinate oxides in moderate to good yields. On basis this catalytic system, styrenes β‐nitrostyrene as well can also give corresponding products cross‐dehydrogenative denitration,...

In order to improve the detonation performance of emulsion explosives, a new type explosives with TiH2 powders is developed. The influences amount sensitizers GMs and energetic additives on explosion characteristics are studied determine optimum compositions. Underwater brisance testing experiments show that, compared traditional sensitized shock wave specific impulse I total energy E GMs-TiH2 improved significantly, effect improving power better than that Ti powders. 23.80 mm compression...

Abstract A three‐component cyclization of 2‐methylquinolines, trimethylsilyl cyanide, and alkylamines or α‐amino acids mediated by CuSO 4 was developed. By employing oxygen as the clean oxidant, cyanated imidazo[1,5‐a]quinolines were constructed with high efficiency for first time. The loading could be lowered to 20 mol% a slightly diminished yield. synthetic utility this method is further highlighted gram‐scale synthesis tolerance sensitive functional group. magnified image

An aerobic Mn(III)-catalyzed one-pot three-component synthesis of 5-cyano-pyrazolo[1,5-a]pyrimidines has been described. The synergistic combination Strecker reaction and oxidatively-induced 6π-azacyclization is the key to success this multicomponent synthesis. Differing from previous reports relied on toxic cyanating agents or multistep synthesis, mechanistically distinct protocol serves as a step-economic, regioselective functionally tolerant strategy obtain...

A convenient copper-catalyzed decarboxylative and oxidative decarbonylative cross-coupling of cinnamic acids with aliphatic aldehydes was achieved, which provides a useful strategy C(sp³)–C(sp²) bonds construction for the synthesis alkyl-substituted <italic>E</italic>-alkenes.

An I 2 O 5 -mediated multicomponent reaction that allows the single-step construction of cyano-functionalized imidazo[1,5- a ]pyridines with molecular diversity was realized for first time.

A simple and efficient Cu(<sc>i</sc>)-catalyzed strategy for synthesis of mutisubstituted furans has been developed this ligand- additive-free annulation method is well suitable both nonactivated arylmethyl ketones 1,3-dicarbonyl compounds.

Iodide-promoted transformations of imidazopyridines into sulfur-bridged or 1,2,4-thiadiazoles have been developed using Deoxofluor as a novel sulfur source at room temperature.

The photoredox ring-opening of imidazoquinolines was developed for the first time, which provides a direct route to imides.