A5047306221- Genetics and Neurodevelopmental Disorders
- Bipolar Disorder and Treatment
- Adolescent and Pediatric Healthcare
- Gender Diversity and Inequality
- Neuroinflammation and Neurodegeneration Mechanisms
- Diversity and Career in Medicine
- Career Development and Diversity
- Mitochondrial Function and Pathology
- interferon and immune responses
- Digital Communication and Language
- Long-Term Effects of COVID-19
- Neurological disorders and treatments
- Anesthesia and Neurotoxicity Research
- SARS-CoV-2 and COVID-19 Research
- Sex and Gender in Healthcare
- Immune cells in cancer
- COVID-19 and Mental Health
- Effects of Radiation Exposure
- Infectious Encephalopathies and Encephalitis
- Adenosine and Purinergic Signaling
Rady Children's Hospital-San Diego
2022-2024
University of California, San Diego
2021-2024
Salk Institute for Biological Studies
2019-2023
University of California System
2021
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19), which was rapidly declared a pandemic by World Health Organization (WHO). Early clinical symptomatology focused mainly on respiratory illnesses. However, variety neurological manifestations in both adults and newborns are now well-documented. To experimentally determine whether SARS-CoV-2 could replicate affect human brain cells, we infected iPSC-derived organoids....
Although microglia are macrophages of the central nervous system, their involvement is not limited to immune functions. The roles during development in humans remain poorly understood due access fetal tissue. To understand how can impact human neurodevelopment, methyl-CpG binding protein 2 (MECP2) gene was knocked out microglia-like cells (MGLs). Disruption MECP2 MGLs led transcriptional and functional perturbations, including impaired phagocytosis. co-culture healthy with MECP2-knockout...
Human exposure to low-to-moderate dose ionizing radiation (LMD-IR) is increasing via environmental, medical, occupational sources. Acute LMD-IR can cause subclinical damage cells, resulting in altered gene expression and cellular function within the human brain. It has been difficult identify diagnostic predictive biomarkers of using traditional research models due factors including lack 3D structure monolayer cell cultures, limited ability animal accurately predict responses, technical...
Abstract Bipolar disorder (BD) is a neuropsychiatric mood manifested by recurrent episodes of mania and depression. More than half BD patients are non-responsive to lithium, the first-line treatment drug, complicating clinical management. Given its unknown etiology, it pertinent understand genetic signatures that lead variability in lithium response. We discovered set differentially expressed genes (DEGs) from lymphoblastoid cell lines (LCLs) 10 controls 19 belonging mainly immunoglobulin...
Abstract Three Prime Repair Exonuclease 1 ( TREX1 ) gene mutations have been associated with Aicardi-Goutières Syndrome (AGS) – a rare, severe pediatric autoimmune disorder that primarily affects the brain and has poorly understood etiology. Microglia are brain-resident macrophages indispensable for development implicated in multiple neuroinflammatory diseases. However, role of DNase cleaves cytosolic nucleic acids, preventing viral- autoimmune-related inflammatory responses microglia...
Abstract Bipolar disorder (BD) is a neuropsychiatric mood manifested by recurrent episodes of mania and depression. More than half BD patients are non-responsive to lithium, the first-line treatment drug, complicating clinical management. Given its unknown etiology, it pertinent understand genetic signatures that lead variability in lithium treatment. We discovered set differentially expressed genes from LCLs 10 controls 19 belonging mainly immunoglobulin gene family can be used as potential...
Disparities for women and minorities in science, technology, engineering, math (STEM) careers have continued even amidst mounting evidence the superior performance of diverse workforces. In response, we launched Diversity Science Lecture series, a cross-institutional platform where junior life scientists present their research comment on diversity, equity, inclusion STEM. We characterize speaker representation from 79 profiles investigate topic noteworthiness via quantitative content...
A ping interrupts the podcast coming through my headphones. It's 6 a.m. and I am working in tissue culture room after an early start because of pandemic-related social distancing requirements. The message is probably from family who live across country, 3 hours ahead me. finish adding media to cells, return dishes incubator, take off gloves, grab phone. read screen let out a deep sigh. WhatsApp mom, with link petition she started wants me sign.
Abstract Disparities for women and minorities in science, technology, engineering, math (STEM) careers have continued even amidst mounting evidence the superior performance of diverse workforces. In response, we launched Diversity Science Lecture series, a cross-institutional platform where junior life scientists present their research comment on equity, diversity, inclusion STEM. We characterize speaker representation from 79 profiles investigate topic noteworthiness via quantitative...