A5075933816- Soil Management and Crop Yield
- Advancements in Transdermal Drug Delivery
- Analytical Methods in Pharmaceuticals
- Public Health in Brazil
- Agricultural and Food Sciences
- Rural Development and Agriculture
- Analytical Chemistry and Chromatography
- Antibiotics Pharmacokinetics and Efficacy
- Phytochemistry Medicinal Plant Applications
- Advanced Drug Delivery Systems
- Drug Solubulity and Delivery Systems
- Bioactive Compounds and Antitumor Agents
- Iron oxide chemistry and applications
- Growth and nutrition in plants
- Pesticide Exposure and Toxicity
- Healthcare Regulation
- Clay minerals and soil interactions
- Pharmaceutical studies and practices
- Pesticide and Herbicide Environmental Studies
- Bee Products Chemical Analysis
- Crystallization and Solubility Studies
- HIV/AIDS drug development and treatment
- Sugarcane Cultivation and Processing
- Protein purification and stability
- Pesticide Residue Analysis and Safety
Universidade Federal de Pernambuco
2015-2024
Centro Hospitalar do Tâmega e Sousa
2023
Centro Universitário Campos de Andrade
2013-2018
Instituto de Ciências Farmacêuticas
2016
Universidade Estadual da Paraíba
2012-2014
Universidade Federal de Sergipe
2005-2011
University of Puerto Rico-Mayaguez
2009
Brazilian Agricultural Research Corporation
1994-2003
Laboratoire de Biophotonique et Pharmacologie
1994
Efavirenz (EFV), a first-line anti-HIV drug largely used as part of antiretroviral therapies, is practically insoluble in water and belongs to BCS class II (low solubility/high permeability). The aim this study was improve the solubility dissolution performances EFV by formulating an amorphous solid dispersion polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer (Soluplus®) using spray-drying technique. To purpose, spray-dried dispersions Soluplus® at different mass...
Abstract Drought tolerance is an increasingly important trait in common bean ( Phaseolus vulgaris L.) due to the reduction water resources, a shift production areas and increasing input costs. The objective of this study was evaluate 29 genotypes for drought under stress (DS) reduced treatments Juana Diaz, Puerto Rico. use DS facilitated identification tolerant germplasm that also had good yield potential more optimal conditions. Based on results seed conditions, indices, including geometric...
A DICLOFENAC DIETHYLAMINE FROM MICROEMULSION GEL-LIKE.The goal of this study was to produce and characterize a new microemulsion gel-like carrier system (MEG) by using the pseudoternary phase-diagram concept.The diclofenac diethylamine (DDA) incorporated in MEG its vitro release permeation profiles were performed Franz-type diffusion cells.The results revealed that commercial DDA emulgel provided significantly higher K p (2.2-fold) as compared MEG.Similar data obtained studies which 4.7-fold...
The aims of this study were to determine the critical hydrophile-lipophile balance (HLB) licuri oil, and perform a clinical assay evaluate its hydrating effects. For determination HLB, serial emulsions prepared with oil. Regarding study, 13 human subjects recruited power emulsified preparation containing comparing it same sweet almond oil (SAO). HLB was represented by zones within concentrations 10% for 15% pair tensoactive agents, value 11.8. Both preparations showed similar power. We...
The aim of this study was to characterize three batches albendazole by pharmacopeial and complementary analytical techniques in order establish more detailed specifications for the development pharmaceutical forms. ABZ01, ABZ02, ABZ03 had melting points 208 ºC, 209 respectively. X-ray diffraction revealed that all showed crystalline behavior absence polymorphism. Scanning electron microscopy samples were crystals different sizes with a strong tendency aggregate. insoluble water (5.07, 4.27,...
The topical bioavailabilities of metronidazole from a commercially available 'reference' product (Rozex®) and two extemporaneous test formulations were compared. With the reference drug product, full skin pharmacokinetic profile, in vivo human volunteers (following 6-h uptake clearance over subsequent 22 h), was obtained using an improved stratum corneum (SC) sampling procedure. Then, two-time point SC method enabled bio(in)equivalence to Rozex® be evaluated. One formulation shown...
FERMENTATION. In the present work, influence of amount nitrogen and phosphorus degrees Brix on yield productivity alcoholic fermentation has been evaluated.The methodology used was factorial design response surface analysis.Within range studied only for a statistically significant effect observed.The broth sugar cane CB 453 variety already possessed enough fermentation.The mathematical empirical model validated not yield.The concentration alcohol produced in to cause cellular growth inhibition.
The analytical method developed to evaluate tamoxifen in dog plasma samples was precise, accurate, robust and linear the range of 5-200 ng/mL. limits detection quantification were 0.981 ng/mL 2.97 ng/mL, respectively. Besides, intra-day precision accuracy variations 8.78 10.16%, Tamoxifen concentrations analyzed by combined reversed phase liquid chromatography UV (lambda=280 nm). study conducted using an open randomized 2-period crossover balanced design with a 1-week washout period between...
Background: The use of valved holding chambers (VHCs) with pressurized metered dose inhalers (pMDIs) is reported to reduce the oral deposition inhaled drugs and facilitate handling these devices by patients, especially children. Although number commercially available VHCs increasing, correct choice VHC in clinical practice important, because are not equally effective regarding medication delivery. Hence, we aimed evaluate three small-volume VHCs—Vortex®, AeroChamber® Plus (ACP), Able Spacer™...
Summary A rapid method using liquid chromatography tandem mass spectrometry for the quantification of olanzapine ( OLZ ) in human plasma was developed and validated. Venlafaxine used as internal standard IS ), samples were extracted from 400‐ μ L with methyl tert ‐butyl ether liquid–liquid extraction. Chromatography performed an ACE C18, 125 × 4.6‐mm i.d., 5‐ m column. The mobile phase consisted water 0.1% formic acid solvent acetonitrile B (50 : 50 v/v) isocratic mode. flow rate 1.2 mL/min....
This survey describes the occurrence of Ethephon (ETH) and Fosetyl in fruits intended for export produced São Francisco Valley, Brazil. The determination these compounds was carried out by QuPPe-method (Quick Polar Pesticides Method), which optimised successfully validated according to SANTE/11813/2017. From January 2016 December 2018 a total 1048 samples were analysed ETH residues. In 547 (53%) samples, residues below EU MRL 1 mg kg-1 present. 17 (2%) above kg-1. Overall, mean level...