A5073567392- Advancements in Transdermal Drug Delivery
- Advanced Drug Delivery Systems
- Surfactants and Colloidal Systems
- Essential Oils and Antimicrobial Activity
- Nanoparticle-Based Drug Delivery
- Characterization and Applications of Magnetic Nanoparticles
- Lipid Membrane Structure and Behavior
- Proteins in Food Systems
- Drug Solubulity and Delivery Systems
- Protein Interaction Studies and Fluorescence Analysis
- Analytical Chemistry and Chromatography
- Antifungal resistance and susceptibility
- Curcumin's Biomedical Applications
- Iron oxide chemistry and applications
- Nail Diseases and Treatments
- Research on Leishmaniasis Studies
- Lipoproteins and Cardiovascular Health
- RNA Interference and Gene Delivery
- Reproductive Health and Contraception
- Microencapsulation and Drying Processes
- Venomous Animal Envenomation and Studies
- Bee Products Chemical Analysis
- Toxin Mechanisms and Immunotoxins
- Bioactive Natural Diterpenoids Research
- Phytochemistry Medicinal Plant Applications
Universidade Federal do Rio Grande do Norte
2016-2025
Translational Therapeutics (United States)
2020-2025
University of Iowa
2020-2025
Universidade Federal do Rio Grande
2020-2021
Universidade Federal do Rio Grande do Sul
2020
National Council for Scientific and Technological Development
2016-2018
Centro de Tecnologias Estratégicas do Nordeste
2018
Universidade Federal de São Paulo
2016
University of Florida
2013
Departamento de Ciência e Tecnologia
2007-2010
Amphotericin B (AmB) is a very efficient drug against serious diseases such as leishmaniasis and systemic fungal infections. However, its oral bioavailability limited due to poor solubility in water. Nevertheless, it marketed high-cost lipid parenteral formulations that may induce infusion-related side effects. In this study, oil-in-water (O/W) microemulsions (MEs) were developed characterized with view their use enhancers delivery systems for AmB. Therefore, different nonionic surfactants...
We report a simple and low cost methodology to synthesize sodium oleate coated magnetite nanoparticles for hyperthermia applications. The system consists of with large susceptibility (1065 emu/gT), induced by the dipolar inter-particle interaction, magnetic core diameter in 6 nm–12 nm size range. In aqueous medium, agglomerate form monodisperse system, exhibiting mean hydrodynamic 60.6 nm±4.1 nm, average polydispersity index 0.128±0.003, as required intravenous exhibits promising efficiency...
Understanding the factors that can modify drug release profile of a from Drug-Delivery-System (DDS) is mandatory step to determine effectiveness new therapies. The aim this study was assess Amphotericin-B (AmB) kinetic profiles polymeric systems with different compositions and geometries correlate these thermodynamic parameters through mathematical modeling. Film casting electrospinning techniques were used compare behavior films fibers, respectively. Release DDSs performed, modeling data...
Chloroquine diphosphate (CQ) is a hydrophilic drug with low entrapment efficiency in hydrophobic nanoparticles (NP). Herpes simplex virus type 1 (HSV-1) an enveloped double-stranded DNA worldwide known as common human pathogen. This study aims to develop chloroquine-loaded poly(lactic acid) (PLA) (CQ-NP) improve the chloroquine anti- HSV-1 efficacy. CQ-NP were successfully prepared using modified emulsification-solvent evaporation method. Physicochemical properties of NP monitored dynamic...
The aim of this work was to investigate the antimicrobial activity nanostructured emulsions based on copaiba (Copaifera langsdorffii) resin-oil, essential oil, and bullfrog (Rana catesbeiana Shaw) oil against fungi bacteria related skin diseases. Firstly, extracted from resin-oil these oils, along with were characterized by gas chromatography combined mass spectrometry (GC-MS). Secondly, emulsion systems produced characterized. susceptibility assay performed, followed Minimum Inhibitory...
Copaiba oil has been largely used due to its therapeutic properties. Nanocapsules were revealed be a great nanosystem carry natural oils their ability improve the bioaccessibility and bioavailability of lipophilic compounds. The aim this study was produce characterize copaiba nanocapsules (CopNc) evaluate hemocompatibility, cytotoxicity, genotoxicity. chemically characterized by GC-MS FTIR. CopNc produced using nanoprecipitation method. physicochemical stability, toxicity, biocompatibility...
This study explores the potential of simvastatin to ameliorate inflammation and infection in open infected skin wounds rats.Fourteen Wistar rats weighing 285 +/- 12g were used. The was done a group whose treated with topical application microemulsion (SIM, n=7) second saline 0.9 % (SAL, n=7). A bacteriological exam fluid for gram positive negative bacteria, tecidual expression TNFá IL-1â by immunohistochemical technique, histological analysis HE stain performed.The TNFa could be clearly...
The cellular uptake and antimycobacterial activity of usnic acid (UA) acid-loaded liposomes (UA-LIPOs) were assessed on J774 macrophages. minimal inhibitory concentration (MIC) the bactericidal (MBC) UA UA-LIPO against Mycobacterium tuberculosis determined. Concentrations required to inhibit 50% cell proliferation (IC50) 22.5 (±0.60) 12.5 (±0.26) μg/ml, for UA-LIPO, respectively. MICs 6.5 5.8 μg/mL, MBC was twice as low (16 μg/mL) that (32 μg/mL). An improvement in intracellular found (21.6...
Topical treatment of cutaneous leishmaniasis represents an exciting alternative for reducing toxicity associated with parenteral administration conventional amphotericin B. This work aims to develop and characterize B-loaded new carriers investigate their potential topical delivery by conducting permeation studies pig ear skin in comparison marketed formulations. Among other formulations, nanoemulsions were developed characterized size, encapsulation efficiency, zeta potential. To mimic use...
Snakebites are a serious worldwide public health problem. In Brazil, about 90% of accidents attributed to snakes from the Bothrops genus. The specific treatment consists antivenom serum therapy, which has some limitations such as inability neutralize local effects, difficult access in regions, risk immunological reactions, and high cost. Thus, search for alternative therapies treat snakebites is relevant. Jatropha mollissima (Euphorbiaceae) medicinal plant popularly used folk medicine an...
Introduction Cannabidiol (CBD), a phytocannabinoid from Cannabis sativa, has several therapeutic properties. However, its high lipophilicity, metabolization, and instability impair bioavailability translational use in clinical settings. Several advanced drug delivery systems (ADDSs) have been evaluated as CBD carriers to overcome these drawbacks. These can improve the dissolution profile, protect it against produce site-specific release, increasing making administration clinically...