A5044748248- Venomous Animal Envenomation and Studies
- Bioactive Natural Diterpenoids Research
- Phytochemistry Medicinal Plant Applications
- Natural product bioactivities and synthesis
- Essential Oils and Antimicrobial Activity
- Ethnobotanical and Medicinal Plants Studies
- Toxin Mechanisms and Immunotoxins
- Phytochemistry and Bioactivity Studies
- Healthcare and Venom Research
- Rabies epidemiology and control
- Marine Invertebrate Physiology and Ecology
- Biochemical and Structural Characterization
- Bioactive Compounds and Antitumor Agents
- Sesquiterpenes and Asteraceae Studies
- Plant Toxicity and Pharmacological Properties
- Powdery Mildew Fungal Diseases
- Phytochemistry and Biological Activities
- African Botany and Ecology Studies
- Herbal Medicine Research Studies
- Psidium guajava Extracts and Applications
- Enzyme Production and Characterization
- Entomological Studies and Ecology
- Plant biochemistry and biosynthesis
- Complementary and Alternative Medicine Studies
- Antimicrobial Peptides and Activities
Universidade Federal do Rio Grande do Norte
2012-2024
Jatropha gossypiifolia L. (Euphorbiaceae) is a medicinal plant largely used in folk medicine. Teas from the leaves are popularly as an antithrombotic agent and branches frequently employed "thick blood" agent. Considering that anticoagulant activity associated with antioxidant properties could be beneficial for various cardiovascular diseases, this study's aim evaluation of activities J. leaves, seeking new therapeutic purposes plant. The aqueous leaf crude extract (CE) was prepared by...
Snakebites are a serious public health problem due their high morbi-mortality. The main available specific treatment is the antivenom serum therapy, which has some disadvantages, such as poor neutralization of local effects, risk immunological reactions, cost and difficult access in regions. In this context, search for alternative therapies relevant. Therefore, aim study was to evaluate antiophidic properties Jatropha gossypiifolia, medicinal plant used folk medicine treat snakebites....
Kalanchoe brasiliensis and pinnata are used interchangeably in traditional medicine the treatment of wound healing. In this context, objective present study was to evaluate local anti-inflammatory activity a topical formulation containing aqueous extract both species. The vivo model ear edema induced by croton oil paw carrageenan. Swiss mice treatments use formulations at different concentrations (1.25%, 2.5%, 5%) or dexamethasone (1 mg/g), all administered topically immediately after...
The growing use of phytotherapy in clinical practice arouses interest studies using medicinal plants as active ingredients for new medicines. Ipomoea pes-caprae has a wide the treatment inflammatory disorders, skin wounds, stings, and painful rheumatic processes. Assayed this study are physicochemical characterization gel developed with extract evaluation its anti-inflammatory healing efficacy, addition to antiedematogenic action on Bothrops snake envenoming mice. qualitative quantitative...
The species Kalanchoe brasiliensis and pinnata, both known popularly as "Saião," are used interchangeably in traditional medicine for their antiophidic properties. Studies evaluating the anti-venom activity of these scarce. This study aims to characterize chemical constituents evaluate inhibitory effects hydroethanolic leaf extracts K. pinnata against local induced by Bothrops jararaca snake venom. Thin Layer Chromatography (TLC) High Performance Liquid coupled with Diode Array Detection...
Bothrops erythromelas is a snake of medical importance responsible for most the venomous incidents in Northeastern Brazil. However, this species not included pool venoms that are used Brazilian polyvalent bothropic antivenom (BAv) production. Furthermore, it well known therapy has limited efficacy against venom-induced local effects, making search complementary alternatives to treat snakebites an important task. Jatropha gossypiifolia medicinal plant widely indicated folk medicine as...
Jatropha gossypiifolia L. (Euphorbiaceae) is a medicinal plant widely used in traditional medicine as an anti-inflammatory remedy. The topical use of the leaves and/or aerial parts this anti-inflammatory, analgesic, wound healing and anti-infective several skin diseases common practice many countries. baths or dressings with vegetal species frequently reported folk medicine.To evaluate aqueous extract from J. to develop safe effective herbal gel potential.First, acute activity was evaluated...
Snakebites are a serious worldwide public health problem. In Brazil, about 90% of accidents attributed to snakes from the Bothrops genus. The specific treatment consists antivenom serum therapy, which has some limitations such as inability neutralize local effects, difficult access in regions, risk immunological reactions, and high cost. Thus, search for alternative therapies treat snakebites is relevant. Jatropha mollissima (Euphorbiaceae) medicinal plant popularly used folk medicine an...
Complexation with cyclodextrins (CDs) is a technique that has been extensively used to increase the aqueous solubility of oils and improve their stability. In addition, this convert into solid materials. This work aims develop inclusion complexes Copaifera multijuga oleoresin (CMO), which presents anti-inflammatory activity, β-cyclodextrin (β-CD) hydroxypropyl-β-cyclodextrin (HP-β-CD) by kneading (KND) slurry (SL) methods. Physicochemical characterization was performed verify occurrence...
Spondias tuberosa is a medicinal plant used by several local communities in northeast Brazil to treat infections, digestive disorders and inflammatory conditions. The study aimed identify quantify the major phenolic hydroethanolic extract of leaves from S. evaluate its anti-inflammatory potential. chemical profile was analyzed HPLC-DAD HPLC-MS. vivo activity investigated carrageenan-induced hind paw edema peritonitis models mice. Identified quantified through or HPLC-MS analyses were...
Scorpionism represents a serious public health problem due to its increasing incidence. In Brazil, Tityus serrulatus is species of major medical importance, especially in children and the elderly, as envenomation may induce acute pulmonary edema. "Mangaba" (Hancornia speciosa Gomes) fruit juice popularly used treatment several inflammatory disorders. The objective this study was analyze chemical composition H. by HPLC-DAD-MS/MS, well evaluate anti-inflammatory potential antioxidant activity,...
Proteolytic enzymes are important macromolecules in the regulation of biochemical processes living organisms. Additionally, these versatile biomolecules have numerous applications industrial segment. In this study we characterized a protein-rich fraction Cnidoscolus urens (L.) Arthur leaves, rich proteolytic enzymes, and evaluated its effects on coagulation cascade. Three fractions were obtained from crude extract C. leaves by precipitation with acetone. Fraction F1.0 showed higher activity...
Jatropha mollissima (Pohl) Baill. (Euphorbiaceae) is widely used in traditional medicine to treat inflammatory disorders. So, a topical gel containing the hydroethanolic extract of its leaves was developed and evaluated for anti-inflammatory, wound healing, antiophidic properties mice. First, chemical profile different parts plant characterized by liquid chromatography coupled mass spectrometry (LC-MS) using molecular networking. In leaf extract, 11 compounds were characterized, with...
Plantas medicinais são utilizadas mundialmente como uma das principais formas de cuidado primário saúde. No entanto, a literatura indica que muitas espécies podem apresentar composição química variável, toxicidade ou difícil identificação. O objetivo do presente estudo foi obter critérios úteis para o controle qualidade farmacognóstico vegetais uso popular no estado Rio Grande Norte, utilizando metodologias análise botânica (morfodiagnose macro e microscópica) (triagem fitoquímica...
This study aimed to determine the phytochemical composition of a root extract Solanum paniculatum Linn. (SPL), and evaluate its in vitro antibacterial activity. The was characterized by screening thin-layer chromatography. following oral bacteria were used minimum inhibitory concentration (MIC) adherence (MICA) Streptococcus mitis (ATCC 903), mutans 25175), sanguinis 15300), oralis 10557), salivarius 7073), Lactobacillus casei 9595). Each assay carried out duplicate positive control (0.12%...
Bullfrog oil (BFO) is a natural product from the adipose tissue of amphibian Rana catesbeiana Shaw, bio-product rich in polyunsaturated fatty acids, which claims anti-inflammatory activity. The objective this work was to evaluate cytotoxicity and activity BFO using vivo vitro assays. Thus, assessed by MTT assay. Additionally, performed carrageenan-induced paw edema model Wistar rats, followed histological analysis. Moreover, effect on inflammatory pathways investigated evaluation nitric...