A5051939215- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Cancer Genomics and Diagnostics
- Estrogen and related hormone effects
- Cancer, Lipids, and Metabolism
- Cancer Cells and Metastasis
- Menopause: Health Impacts and Treatments
- Health and Lifestyle Studies
- Nutrition and Health in Aging
- Genetic factors in colorectal cancer
- Axon Guidance and Neuronal Signaling
- Cancer Immunotherapy and Biomarkers
- Obesity, Physical Activity, Diet
- Pregnancy-related medical research
- Prenatal Screening and Diagnostics
- Bone health and osteoporosis research
- Cleft Lip and Palate Research
- Fetal and Pediatric Neurological Disorders
- Cancer Diagnosis and Treatment
- Mesenchymal stem cell research
- Hippo pathway signaling and YAP/TAZ
- Eating Disorders and Behaviors
- Natural Products and Biological Research
- Lymphatic System and Diseases
Finis Terrae University
2016-2025
Austral University of Chile
2023
University of Chile
2003-2017
National University of Rosario
2016
University of Cartagena
2016
Universidad Católica de Santiago de Guayaquil
2016
Universidad Nacional de Cuyo
2016
Hospital Clínico de la Universidad de Chile
2015
Hospital Santiago Oriente - Dr. Luis Tisne Brousse
2013
The aim of the study was to evaluate association between sedentary lifestyle and severity menopausal symptoms obesity in middle-aged women.The Menopause Rating Scale, Goldberg Anxiety Depression Athens Insomnia Scale were administered 6,079 Latin American women aged 40 59 years. Sedentary defined as fewer than three weekly, 30-minute periods physical activity.Sedentary had more severe (total score: 9.57 ± 6.71 vs 8.01 6.27 points, P < 0.0001) depressive (Goldberg), anxiety insomnia (Athens...
Angiogenesis, the process in which new blood vessels are formed from preexisting ones, is highly dependent on presence of classical angiogenic factors. Recent evidence suggests that axonal guidance proteins and their receptors can also act as regulators. Netrin, a family laminin-like proteins, specifically Netrin-1 4, via DCC/Neogenin-1 UNC5 class to promote or inhibit angiogenesis, depending physiological context. Mesenchymal stem cells secrete broad set However, little known about...
Metformin may decrease cell senescence, including bone; hence we aimed at evaluating the association between metformin use and osteoporosis. This was a cross-sectional study carried out in 1259 Latin American adult women aged 40 or more who were not on anti-osteoporotic drugs, had bone densitometry performed. Of whole sample, 40.3% reported being (at least 1 year), 30.2% type 2 diabetes mellitus 22.6% Median (interquartile range) body mass index (BMI) for cohort 27.7 (4.6) kg/m2 mellitus....
Wharton's Jelly mesenchymal stem cells (WJ-MSCs) are an attractive potential source of multipotent for bone tissue replacement therapies. However, the molecular mechanisms involved in their osteogenic conversion poorly understood. Particularly, epigenetic control operating at promoter regions two master regulators program, RUNX2/P57 and SP7 has not yet been described WJ-MSCs. Via quantitative PCR profiling chromatin immunoprecipitation (ChIP) studies, here we analyze ability WJ-MSCs to...
Aim: This study aimed to the prevalence of vitamin D deficiency, assessing influence sex, age, and season year.Methods: A cross-sectional was conducted with 1329 healthy subjects (668 women 661 men) aged 18–89 years in Santiago, Chile. Age (years), body mass index, medical history, working status, date blood sample were collected.Results: Men slightly older than (53.1 ± 18.2 vs. 50.0 15.6 years; p < 0.01) a higher percentage worked outside home (73.1% 51.9%, 0.001). The mean serum...
To evaluate the association between menopausal symptoms and cognitive decline in postmenopausal women.
Chile is a country where teledermatology has been growing exponentially since the implementation of single national asynchronous platform for public system in December 2018. To ensure quality care systems, it crucial to evaluate fulfillment basic specifiers such as ICD-Diagnosis, therapeutic suggestions, and diagnostic among others. This article aims Chilean health service by analyzing 243 randomly extracted consultations, representative 20,716 electronic consultations performed during 2020....
Introduction: Minimal residual disease (MRD) remaining after curative therapy for prostate cancer has the potential growth and can result in metastasis. Circulating cells (CPCs) bone marrow micro-metastasis (mM) could represent different types of MRD. We here determined; biochemical failure free survival rates; time to BF 10 years follow-up; presence CPCs mM patients treated with radical prostatectomy (RP) cancer. Methods Patients: One month RP, blood were sampled assessment mM. Cases...
Bloodstream infections in children with cancer and high risk fever neutropenia episodes six hospitals of Santiago, Chile between 2004 2009 Introduction: To determine the etiology invasive bacterial infection febrile (HRFN) is essential because favorable impact on mortality early empiric antibiotic treatment.Objective: bacteremia pediatric patients HRFN National Child Program Antineoplastic Drugs during 2004-2009 period, compare these agents their antimicrobial susceptibility period 1994-1998...
To establish a prediction model for early biochemical recurrence based on the Cancer of Prostate Risk Assessment (CAPRA) score and presence secondary circulating prostate cells (CPCs).We conducted prospective single-centre study men who underwent radical prostatectomy as monotherapy cancer. Clinicopathological findings were used to calculate CAPRA score. At 90 days after surgery, blood was taken CPC detection, mononuclear obtained using differential gel centrifugation, CPCs identified...
Introduction:The Gleason score is a strong prognostic factor for treatment failure in pathologically organ-confined prostate cancer (pT2) treated by radical prostatectomy (RP).However, within each score, there clinical heterogeneity with respect to outcome, even patients the same pathological stage and prostatespecific antigen (PSA) at diagnosis.This may be due minimal residual disease (MRD) remaining after surgery.We hypothesise that sub-type of MRD determines risk timing failure,...
25% of Stage III colon cancer patients relapse within 5 years due to minimal residual disease (MRD) not eliminated by surgery and chemotherapy. We hypothesise that sub-types MRD, defined circulating tumour cells (CTCs) bone marrow micro-metastasis (mM) have different types kinetics relapse.One month curative 1 after completing six cycles FOLFOX chemotherapy blood samples were taken detect CTCs mM using immunocytochemistry with anti-carcino-embryonic antigen (CEA). Follow up was or...
Abstract Objective Musculoskeletal disorders frequently affect postmenopausal women. This study aims to compare muscle between women according the type of experienced menopause: premature (PM) or normal age menopause (NAM). Methods was a cross-sectional conducted in nine Latin American countries which late (55 70 years) were surveyed with general questionnaire, Menopause Rating Scale (MRS: item #4 exploring musculoskeletal discomfort), and strength, assistance walking, rising from chair,...
Objective: The biological characteristics of circulating prostate cells (CPCs) are probably more important than their mere presence. CD82 is a tumor suppressor, we present the outcome radical prostatectomy (RP) in men with positive CPCs. Methods and Patients: consecutive treated RP were studied, age, total PSA, Gleason, stage, presence extra-capsular extension, surgical margens infiltration seminal vesicles lymph nodes registered. Biochemical failure was defined as PSA >0.2ng/ml. Immediately...
This study aims to determine time differences (differences in restricted mean survival times [RMSTs]) the onset of invasive breast cancer, coronary heart disease, stroke, pulmonary embolism, colorectal and hip fracture between placebo group conjugated equine estrogens 0.625 mg plus medroxyprogesterone acetate 2.5 Women's Health Initiative (WHI) trial based on curves original report provide adequate interpretation clinical effects a given intervention.Distribution function was obtained from...
To report normative data for the fetal nasal bone length (NBL), frontonasal fold (FNF) thickness, and FNF/NBL ratio to study their performance in sonographic screening of trisomy 21 a normal, unselected Latin American population.Women undergoing routine examination between 16 32 weeks' gestation at primary health care center Santiago, Chile, were prospectively recruited NBL FNF thickness measurements. Pregnancies with maternal/fetal complications subsequently excluded from analysis....
Introduction: In women, bone mineral density (BMD) is related to age, estrogenic action, and appendicular skeletal muscle mass (ASMM). The gynoid fat distribution linked action.Objective: This study aimed assess whether an increase of associated with high BMD independent age ASMM.Methods: An observational was performed in women aged between 20 79 years. Fat mass, ASMM, were measured dual-energy X-ray absorptiometry. binned scatterplots multivariate linear regression models used the...
Objectives To report normative data for the fetal nasal bone length (NBL), frontonasal fold (FNF) thickness, and FNF/NBL ratio to study their performance in sonographic screening of trisomy 21 a normal, unselected Latin American population. Methods Women undergoing routine examination between 16 32 weeks' gestation at primary health care center Santiago, Chile, were prospectively recruited NBL FNF thickness measurements. Pregnancies with maternal/fetal complications subsequently excluded...
The aim of this study was to assess resilience, fear COVID-19, sleep disorders, and menopause-related symptoms after the acute phase COVID-19 in middle-aged women with positive reverse transcription-polymerase chain reaction noninfected women.This is a cross-sectional, analytical climacteric from 9 Latin American countries, aged 40-64 years, attending routine health checkup. We evaluated clinical characteristics used Connor-Davidson Resilience Scale, Fear Jenkins Sleep Menopause Rating Scale...