A5073148412- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Functional Brain Connectivity Studies
- Medical Imaging Techniques and Applications
- Parkinson's Disease Mechanisms and Treatments
- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Neurological Disease Mechanisms and Treatments
- Lung Cancer Diagnosis and Treatment
- Cerebrovascular and Carotid Artery Diseases
- Ginkgo biloba and Cashew Applications
- Esophageal Cancer Research and Treatment
- Spatial Neglect and Hemispheric Dysfunction
- Health Systems, Economic Evaluations, Quality of Life
- EEG and Brain-Computer Interfaces
- Advanced X-ray and CT Imaging
- Neurological disorders and treatments
- Neurological and metabolic disorders
- Cardiovascular Function and Risk Factors
- Diet and metabolism studies
- Medical Imaging and Pathology Studies
- Neurological Disorders and Treatments
- Gastric Cancer Management and Outcomes
- Advanced Neuroimaging Techniques and Applications
- ECG Monitoring and Analysis
Newcastle upon Tyne Hospitals NHS Foundation Trust
2014-2024
Royal Victoria Infirmary
2006-2023
Newcastle University
2015-2023
University of Cambridge
2021-2023
University of Exeter
2023
Clinical Research Institute
2022
University of Newcastle Australia
2022
Exeter Hospital
2021
Newcastle upon Tyne Hospital
2007-2020
Newcastle Hospitals - Campus for Ageing and Vitality
2018-2019
Brain imaging with glucose (<sup>18</sup>F-FDG) PET or blood flow (hexamethylpropyleneamine oxime) SPECT is widely used for the differential diagnosis of dementia, though direct comparisons to clearly establish superiority one method have not been undertaken. <b>Methods:</b> Subjects Alzheimer disease (AD; <i>n</i> = 38) and dementia Lewy bodies (DLB; 30) controls (<i>n</i> underwent <sup>18</sup>F-FDG in balanced order. The main outcome measure was area under curve (AUC)...
The accurate clinical characterisation of mild cognitive impairment (MCI) is becoming increasingly important. aim this study was to compare the neuropsychiatric symptoms and profile MCI with Lewy bodies (MCI-LB) Alzheimer's disease (MCI-AD).Participants were ⩾60 years old MCI. Each had a thorough neuropsychological assessment 2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl)-nortropane single photon emission computed tomography FP-CIT SPECT). MCI-LB diagnosed if two or more diagnostic...
Dopaminergic imaging has high diagnostic accuracy for dementia with Lewy bodies (DLB) at the stage. We report first investigation of dopaminergic prodromal stage.We recruited 75 patients over 60 mild cognitive impairment (MCI), 33 probable MCI body disease (MCI-LB), 15 possible MCI-LB and 27 Alzheimer's disease. All underwent detailed clinical, neurological neuropsychological assessments FP-CIT [123I-N-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl)] imaging. scans were blindly rated by a...
Abstract Objectives To investigate using quantitative EEG the (1) differences between patients with mild cognitive impairment Lewy bodies (MCI-LB) and MCI Alzheimer’s disease (MCI-AD) (2) its utility as a potential biomarker for early differential diagnosis. Methods We analyzed eyes-closed, resting-state, high-density data from highly phenotyped participants (39 MCI-LB, 36 MCI-AD, 31 healthy controls). measures included spectral power in different frequency bands (delta, theta, pre-alpha,...
Recently published diagnostic criteria for mild cognitive impairment with Lewy bodies (MCI-LB) include five neuropsychiatric supportive features (non-visual hallucinations, systematised delusions, apathy, anxiety and depression). We have previously demonstrated that the presence of two or more these symptoms differentiates MCI-LB from MCI due to Alzheimer's disease (MCI-AD) a likelihood ratio >4. The aim this study was replicate findings in an independent cohort.Participants ⩾60 years old...
To provide evidence that cardiac I-123-metaiodobenzylguanidine sympathetic innervation imaging (MIBG) scintigraphy differentiates probable mild cognitive impairment with Lewy bodies (MCI-LB) from due to Alzheimer disease (MCI-AD), we scanned patients MCI and obtained consensus clinical diagnoses of their subtype. We also performed baseline FP-CIT scans compare the accuracy MIBG FP-CIT.We conducted a prospective cohort study into in diagnosis MCI-LB. Follow-up assessment was used diagnose...
The aim of this study was to determine the feasibility and accuracy sentinel lymph node (SLN) biopsy for oesophageal adenocarcinoma.Fifty-seven patients with adenocarcinoma lower oesophagus (n = 40) or gastric cardia 17) underwent endoscopic peritumoral injection (99m)Tc-radiolabelled nanocolloid before en bloc resection extended lymphadenectomy. SLNs were identified during surgery using a handheld gamma probe pattern radioactive uptake quantified after operation. All 1667 resected nodes...
Background: The aim of this study is to investigate the diagnostic value perfusion 99mTc-exametazime single photon emission computed tomography (SPECT) in diagnosis dementia with Lewy bodies (DLB) and Alzheimer's disease (AD) comparison dopaminergic 123I-2β-carbomethoxy-3β-(4-iodophenyl)-n-(3-fluoropropyl) nortropane (FP-CIT) SPECT imaging.Methods: Subjects underwent scanning (39 controls, 36 AD, 30 DLB) 123I-FP-CIT (33 33 28 DLB). For each scan, five raters performed visual assessments...
ABSTRACT Background : Amyloid deposition is common in dementia with Lewy bodies, but its pathophysiological significance unclear. Objective The objective of this study was to investigate the relationship between amyloid and clinical profile, gray matter volume, brain perfusion bodies. Methods Dementia bodies (n = 37), Alzheimer's disease 20), controls 20) underwent a thorough assessment, 3T MRI, early‐ late‐phase 18 F‐Florbetapir PET‐CT assess cortical deposition, respectively. scans were...
Positron emission tomography (PET) and single photon computed (SPECT) brain imaging are widely used as diagnostic tools for suspected dementia but no studies have directly compared participant views of the two procedures. We a range methods to explore preferences PET SPECT.Patients controls (and accompanying carers) completed questionnaires immediately after undergoing SPECT scans. Pulse rate data were collected during each scan. Scan attributes prioritized using card sorting exercise;...
Background Dopaminergic imaging is an established biomarker for dementia with Lewy bodies, but its diagnostic accuracy at the mild cognitive impairment (MCI) stage remains uncertain. Aims To provide robust prospective evidence of dopaminergic MCI to either support or refute inclusion as a diagnosis bodies. Method We conducted study baseline [ 123 I] N -ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl)nortropane single-photon emission computerised tomography ( I-FP-CIT SPECT) in 144 patients...
To investigate in vivo degeneration of the cholinergic system mild cognitive impairment with Lewy bodies (MCI-LB), we studied nucleus basalis Meynert (NBM) volumes from structural MR images and its relation to EEG slowing impairment. We NBM using 37 patients MCI-LB, 34 MCI Alzheimer's disease (MCI-AD), 31 healthy control participants. also tested correlations between measures overall cognition groups. Overall volume was reduced MCI-LB compared controls no significant difference MCI-AD or two...
IntroductionAmyloid-β (Aβ) deposition is common in dementia with Lewy bodies (DLB) and has been associated more rapid disease progression. An effective biomarker that identified the presence of significant brain Aβ people DLB may be useful to identify stratify participants for research studies inform prognosis clinical practice. Plasma biomarkers are emerging as candidates fulfil this role.MethodsThirty-two had amyloid (18F-florbetapir) PET, whom 27 also an MRI enable calculation...
Clinical parkinsonism is a core diagnostic feature for mild cognitive impairment with Lewy bodies (MCI-LB) but can be challenging to identify. A five-item scale derived from the Unified Parkinson's Disease Rating Scale (UPDRS) has been recommended assessment of in dementia. This study aimed determine whether effective identify MCI.
In Europe, where sunscreens are classified as cosmetics, products may contain one or several of 27 permitted 'ultraviolet filters'. We were unable to find published data on the frequency usage individual ultraviolet (UV)-absorbing chemicals in currently available sunscreens.To record active ingredients and labelling characteristics UK.In 2005, two dermatologists visited seven retail outlets, which stocked a large range sunscreens. Manufacturers also contacted. For each product, names...
Extra-cardiac activity can interfere with observer interpretation of myocardial perfusion single photon emission computed tomography (SPECT) images. Fatty meals and drinks to reduce interference have been tested; however, a simple study delayed imaging (99m)Tc-tetrofosmin (99m)Tc-sestamibi has not specifically addressed. The aim was quantify the effects time, radiopharmaceutical oral administration full fat milk water on interfering activity.Myocardial SPECT images were acquired using either...
Progressive nigrostriatal pathway degeneration occurs in individuals with dementia Lewy bodies (LB). Our objective was to investigate whether repeat 123[I]-N-(3-fluoropropyl)-2β-carboxymethoxy-3β-(4-iodophenyl) nortropane (FP-CIT) single photon emission computed tomography (SPECT) can identify progressive dopaminergic loss mild cognitive impairment (MCI) (MCI-LB).
Mild cognitive impairment with Lewy bodies (MCI-LB) is associated a range of cognitive, motor, neuropsychiatric, sleep, autonomic, and visual symptoms. We investigated the cumulative frequency symptoms in longitudinal cohort MCI-LB compared MCI due to Alzheimer disease (MCI-AD) analysed ability previously described 10-point symptom scale differentiate MCI-AD, an independent cohort.
We examined 99m Tc-exametazime brain blood flow single-photon emission computed tomography (SPECT) images using a spatial covariance analysis (SCA) approach to assess its diagnostic value in distinguishing dementia with Lewy bodies (DLB) from Alzheimer's disease (AD). Voxel SCA was simultaneously applied set of preprocessed (AD, n = 40; DLB, 26), generating series eigenimages representing common intercorrelated voxels AD and DLB. Linear regression derived pattern (SCP) that discriminated DLB...