A5102712809- Childhood Cancer Survivors' Quality of Life
- Lymphoma Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Sarcoma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Viral-associated cancers and disorders
- Ocular Oncology and Treatments
- Chemotherapy-induced cardiotoxicity and mitigation
- Cancer Risks and Factors
- Palliative Care and End-of-Life Issues
- Brain Metastases and Treatment
- Family Support in Illness
- Chemotherapy-induced organ toxicity mitigation
- CNS Lymphoma Diagnosis and Treatment
- Ocular Disorders and Treatments
- Renal and related cancers
- Myasthenia Gravis and Thymoma
- Pharmacological Effects and Toxicity Studies
- Acute Myeloid Leukemia Research
- Hematological disorders and diagnostics
- Pediatric Pain Management Techniques
- Central Venous Catheters and Hemodialysis
- Occupational and environmental lung diseases
- CAR-T cell therapy research
- Ethics and Legal Issues in Pediatric Healthcare
Ankara University
2015-2024
Pediatric Oncology Group
2001-2019
Tel Aviv Sourasky Medical Center
2018
Support group for adolescents and children with cancer
2018
Sydney Children's Hospital
2018
Memorial Sloan Kettering Cancer Center
2018
Université Paris-Saclay
2018
Université Paris-Sud
2018
Jazz Pharmaceuticals (United States)
2018
Novo Nordisk (United Kingdom)
2018
Purpose: To evaluate the presentation patterns and results of management retinoblastoma at a tertiary care center in Ankara, Turkey, with special emphasis on globe conservation rate unilateral bilateral intraocular retinoblastoma. Methods: Patients were grouped according to International Classification Retinoblastoma. For retinoblastoma, group E some D eyes underwent primary enucleation. Secondary enucleation was performed after failure chemoreduction, focal treatments, external beam...
Advanced intraocular tumors and metastatic disease in retinoblastoma patients still occur frequently developing countries. The aim of this retrospective study was to describe the clinical epidemiological characteristics with effects these features on prognosis authors' pediatric oncology unit as a country profile define problem. A chart review 91 who presented between May 1996 December 2003 conducted study. Patients unilateral at median age 24 months those bilateral 9.5 (p < .01). Most eyes...
Background: Long-term survivors of Hodgkin lymphoma (HL) are at risk developing a range late effects, with second malignant neoplasm and cardiovascular diseases being the leading causes death in these patients. The present study aims to evaluate side effects children HL. Materials Methods: Out 53 HL patients, we assessed long-term childhood (HLSs; n = 50) diagnosed between 1998 2019. Patient data related chronic health conditions, sociodemographic characteristics were compared their siblings...
e22002 Background: Pain is one of the most important problems that affects more than half cancer patients at any stage disease and disrupts quality life patients. The aim should be to relieve pain as soon possible prevent its recurrence. In this study, we aimed evaluate clinical characteristics our who were followed up with a diagnosis in clinic whose management was planned multidisciplinary manner department Algology. where study conducted reference center middle income developing country....
AbstractSixty-three Turkish children with Burkitt's lymphoma (BL) diagnosed over a 10-year period in single institution were retrospectively analyzed. included 41.7% of non-Hodgkin's lymphomas and 17.2% all childhood malignant solid tumors our department this duration. The patients studied BL aged between 3 14 years (mean 5.9 years), male to female ratio 2:1. While the age distribution was similar that African (endemic), predominance abdominal involvement frequency bone marrow infiltration...
The aim of the present study was to evaluate efficiency and side effects mifamurtide in childhood osteosarcoma (OS). In total, 477 doses 2 mg/m intravenous (IV) mifamurtide, along with paracetamol as a premedication, were given 15 patients primary nonmetastatic OS after complete surgical resection 3 progressive OS. most common encountered chills fever (17/18). These reactions observed 4 during administration each dose, single patient last administration, remaining 12 first or initial...
Background/aim: Bloodstream infections are the major cause of morbidity, increased cost, prolonged hospitalization, and mortality in pediatric patients. Identifying predominant microorganisms antimicrobial susceptibilities centers helps to select effective empirical antimicrobials which leads positive clinical outcomes. We aimed identify causative their patients with bloodstream infections.Materials methods: Data belonging hematological and/or oncological diseases admitted our hospital fever...
Abstract Background : The CD44, a cell surface proteoglycan, participates in variety of function including tumor dissemination and metastasis. However, there are no available data on the prognostic significance CD44 expression tissue correlated with serum sCD44 level childhood leukemias lymphomas. Methods Serum levels leukemic were detected 54 children acute leukemia malignant lymphoma. samples obtained from all patients before treatment during remission. Twelve age‐matched healthy included...
Non-Hodgkin lymphoma (NHL) includes pathologies of different clinical courses, treatments, outcomes. Our study aims to investigate the late effects NHL survivors (NHLS).Among 59 cases, 50 completed their treatment between 2003 and 2019. Out patients, cumulative survival rates event-free after 10 years since diagnosis were 82.9% ±5.2% 84.1% ±5.2%, respectively. In addition, we compared data related chronic health psychosocial conditions with siblings (n = 61).The age gender ratios similar in...
Thymic carcinoma, which is a thymic epithelial neoplasm with obvious cytologic atypia, rare neoplasm. The authors report on 10-year-old boy who presented respiratory distress due to bulky anterior mediastinal mass. Histological and immunohistochemical studies confirmed lymphoepithelioma-like pattern carcinoma. In addition, evaluation of the specimen showed foci caseation multiple granulomas extensive central necrosis within tissue. child received chemotherapy, followed by surgery...
Patients who survive Hodgkin lymphoma (HL) are at increased risk of secondary neoplasms (SNs). A wide variety SNs have been reported, including leukemias, non-Hodgkin's lymphomas, and solid tumors, specifically breast thyroid cancers. Herein we report subsequent in four patients with HL receiving chemoradiotherapy. It is interesting that three SNs, fibrosarcoma, carcinoma, retrobulbar meningioma, were observed the radiation area one our patients. hypopharyngeal epithelioid malignant...
Loss-of-function mutations in magnesium transporter 1 (MAGT1) gene cause X-linked deficiency with Epstein–Barr virus (EBV) infection and neoplasm (X-MEN), a disease quite diverse clinical immunological consequences. The phenotypic characteristics of the initially described patients included CD4+ T cell lymphopenia, immune deficiency, EBV viremia, EBV-related lymphoproliferative disease. To date, total 25 have been reported. spectrum MAGT1 defect ranges from other viral infections (HSV, VZV,...
Aim: The main purpose of this study is to determine the current status long-term follow-up (LTFU) for childhood cancer survivors and challenges LTFU pediatric at oncology institutions in Turkey. Material methods: A questionnaire was e-mailed directors 33 centers (POCs) registered Turkish Pediatric Oncology Group (TPOG). Of these active TPOG institutions, 21 participated returned their completed questionnaires. Results: Only 1 participating had a separate clinic. remaining provided care...
Hodgkin`s lymphoma (HL) is highly curable disease in its early stages, but advanced it presents a dilemma when becomes refractory or relapses after several rounds of chemotherapy. Brentuximab vedotin (BV) an antibody-drug conjugate that targets the tumor necrosis receptor family protein member CD30 positive malignancies via anti-CD30 monoclonal antibody linked to monomethyl auristatin-E. In adult and pediatric studies, has been shown be effective salvage therapy for primary HL relapse...
Tural Kara T, Özdemir H, Erat Yahşi A, Aysev AD, Taçyıldız N, Ünal E, İleri İnce Haskoloğlu Ş, Çiftçi E. Is antibiotic lock therapy effective for the implantable long-term catheter-related bloodstream infections in children? Turk J Pediatr 2019; 61: 895-904. Catheter-related (CRBSIs) are an important problem pediatric patients with central venous catheters. This study aimed to determine incidence of CRBSIs, responsible pathogens and outcomes treatment (ALT) patients. Between January 2010...
In this study, 82 Turkish children with Hodgkin's disease (HD) between 1 and 14 years of age diagnosed over a 10-year period were evaluated retrospectively. More than half the patients (54%) presented advanced stages HD. Mixed cellularity (MC) was most frequent (56.1%) histopathologic type, which followed by nodular sclerosing (NS, 18.3%) in frequency. None received radiotherapy as initial treatment. 67 COPP regimen alone 15 ABVD alternating started, to be given total 12 courses. who stage...
In the etiology of childhood cancers, many genetic and environmental factors play a role. One these could be cigarette smoking, main source tobacco smoke exposure children is parental smoking. However, establishing causal relationship between smoking cancers has proven challenging due to difficulties in accurately detecting METHODS: To address this issue, we used hair cotinine analysis questionnaire get information about exposures pediatric cancer patients healthy children. A total 104 99...
Denosumab,a monoclonal IgG2 antibody directed against RANK-L,is used as a neoadjuvant therapy for inoperable or metastatic giant cell tumor of bone. Many side effects like hypocalcemia during treatment and rarely severe hypercalcemia especially in children after discontinuation denosumab occurred. The unpredictable onset recurrent episodes increase the duration hospitalization risk complications. Persistent difficulties management have prompted search different more effective therapeutic...