A5102986656- Organ Transplantation Techniques and Outcomes
- Transplantation: Methods and Outcomes
- Cardiac Ischemia and Reperfusion
- Advanced MRI Techniques and Applications
- Mitochondrial Function and Pathology
- Coenzyme Q10 studies and effects
- Metalloenzymes and iron-sulfur proteins
- Medical Imaging Techniques and Applications
- Radiation Detection and Scintillator Technologies
- Childhood Cancer Survivors' Quality of Life
- Cancer Risks and Factors
- Hormonal and reproductive studies
- Crystallography and Radiation Phenomena
- Immunotherapy and Immune Responses
- Biochemical Acid Research Studies
- Advanced NMR Techniques and Applications
- Lanthanide and Transition Metal Complexes
- Pharmacological Effects of Natural Compounds
- Advanced Neuroimaging Techniques and Applications
- Nuclear Physics and Applications
- Cancer, Hypoxia, and Metabolism
- Bioactive Compounds and Antitumor Agents
- Cytokine Signaling Pathways and Interactions
- Signaling Pathways in Disease
- Platelet Disorders and Treatments
Ankara University
2021-2024
Lund University
2024
Boston Children's Hospital
2022-2024
Harvard University
2023-2024
Trakya University
2023
Boston Children's Museum
2022
Forschungszentrum Jülich
2006-2021
Prostate and ovarian cancers affect the male female reproductive organs are among most common in developing countries. Previous studies have demonstrated that cancer cells a high rate of aerobic glycolysis is present nearly all invasive human persists even under normoxic conditions. Aerobic has been correlated with chemotherapeutic resistance tumor aggressiveness. These data suggest mitochondrial dysfunction may confer significant proliferative advantage during somatic evolution cancer. In...
Ischemia-reperfusion injury (IRI) plays a crucial role in the development of primary graft dysfunction (PGD) following lung transplantation. A promising novel approach to optimize donor organs before transplantation and reduce incidence PGD is mitochondrial In this study, we explored delivery isolated mitochondria 4 hour ex vivo perfusion (EVLP) as means mitigate IRI. To provide fresh viable source mitochondria, well streamline workflow without need for muscle biopsies, investigated impact...
Magnetic resonance is a major preclinical and clinical imaging modality ideally suited for longitudinal studies, e.g. in pharmacological developments. The lack of proven platform that maintains an identical protocol between platforms solved with the construction animal scanner based on hard- software. A small magnet gradient system were connected to MR system. Several hardware components either modified or built in-house achieve compatibility. software was account different field-of-view...
Abstract Reduced mitochondrial function increases myocardial susceptibility to ischemia–reperfusion injury (IRI) in diabetic hearts. Mitochondrial transplantation (MT) ameliorates IRI, however, the cardioprotective effects of MT may be limited using mitochondria. Zucker Diabetic Fatty (ZDF) rats were subjected temporary RI and then received either vehicle alone or containing mitochondria isolated from ZDF non-diabetic lean (ZL) rats. The allowed recover for 2 h 28 days. ZDF- ZL-mitochondria...
Background: Erectile Dysfunction (ED) is a common sexual disorder among men aged 20 years and over. It predominantly characterized by alterations in the key physiological pathways regulating erectile function, such as nitric oxide Ras homolog gene family member A (RhoA)/Rho-associated protein kinase (ROCK). Beyond these pathways, multiple molecular signaling networks are involved ED pathogenesis. Objective: This review aims todescribe major signal transduction that impact function contribute...
Abstract Objectives Breast cancer is the second cause of death among women worldwide. In last decades, immunotherapy-based approaches have a growing importance in treatment breast cancer. Several studies indicated pleiotrophic effect Interleukin-6 (IL-6) via targeting membrane-bound or soluble receptors. Materials and methods Different concentrations IL-6 were incubated for 24, 48, 72 h carcinoma cell line (MCF-7). Cell proliferation, apoptotic population, gene expression by RT-PCR measured,...
In the etiology of childhood cancers, many genetic and environmental factors play a role. One these could be cigarette smoking, main source tobacco smoke exposure children is parental smoking. However, establishing causal relationship between smoking cancers has proven challenging due to difficulties in accurately detecting METHODS: To address this issue, we used hair cotinine analysis questionnaire get information about exposures pediatric cancer patients healthy children. A total 104 99...
Simultaneous MR-PET is an increasingly popular multimodal imaging technique that able to combine metabolic information obtained from PET with anatomical/functional MRI. One of the key technological challenges integration a PET-transparent MR coil system, solution which demonstrated here for double-tuned <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sup> H/ xmlns:xlink="http://www.w3.org/1999/xlink">31</sup> P head at 3 T. Two...
Haemophilia is a bleeding disorder that occurs due to the deficiency of coagulation factors, and angiogenesis process an important underlying pathophysiology haemophilic arthropathy. The role new adipocytokine endoglin (ENG) in patients with haemophilia not yet known.The aim this study evaluate association between ENG protein angiogenesis-related cytokines for first time.Plasma levels mRNA expressions various angiogenesis-associated were compared blood samples collected from 28 A or B 29...
Introduction: Heart transplantation in pediatric and neonatal patients is limited by the donor pool. Donation after circulatory death (DCD) could potentially expand pool offering an additional source of cardiac allografts. In this study, we investigated efficacy mitochondrial to enhance myocardial function DCD hearts. Hypothesis: Autologous enhances viability Methods: Circulatory was induced extubation (25 - 50g heart weight, representing 4-16 month human) (68 98g 4-6 year swine model....
Abstract Leigh syndrome (LS), a rare hereditary neurometabolic disorder caused by mitochondrial dysfunction, results from genetic mutations affecting the central nervous system. Endogenous bioactive antioxidant Coenzyme Q10 (CoQ10) deficiency is associated with LS and contributes to various clinical symptoms. Dequalinium chloride (DQA) bolalipid mitochondria-targeting properties. This study aimed develop CoQ10-loaded DQAsomes enhance CoQ10 solubility delivery mitochondria for potential...
OBJECTIVES In the etiology of childhood cancers, many genetic and environmental factors play a role. One these is cigarette smoking main source tobacco smoke exposure children parental smoking. However, establishing causal relationship between cancers has proven challenging due to difficulties in accurately detecting METHODS To address this issue, we used hair cotinine analysis questionnaire get information about exposures pediatric cancer patients healthy children. 104 99 participated our...