A5009043575- Insect and Arachnid Ecology and Behavior
- Plant and animal studies
- Animal Behavior and Reproduction
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Insect behavior and control techniques
- Livestock and Poultry Management
- Physiological and biochemical adaptations
- Silkworms and Sericulture Research
- Antibiotics Pharmacokinetics and Efficacy
- Behavioral Health and Interventions
- Species Distribution and Climate Change
- Bacterial Identification and Susceptibility Testing
- Antibiotic Resistance in Bacteria
- Insect Utilization and Effects
- Aquaculture Nutrition and Growth
- Evolution and Genetic Dynamics
- Lysosomal Storage Disorders Research
- Mycobacterium research and diagnosis
- Glycosylation and Glycoproteins Research
- Neutropenia and Cancer Infections
- Cancer Genomics and Diagnostics
- Insect and Pesticide Research
- Genetics, Aging, and Longevity in Model Organisms
- Insect Pest Control Strategies
- Insect-Plant Interactions and Control
Harvard University
2015-2022
Evolutionary Genomics (United States)
2019-2021
Harvard University Press
2015-2021
Stanford University
2016
Individual animals behave differently from each other. This variability is a component of personality and arises even when genetics environment are held constant. Discovering the biological mechanisms underlying behavioral depends on efficiently measuring individual bias, requirement that facilitated by automated, high-throughput experiments. We compiled large data set locomotor behavior measures, acquired over 183,000 fruit flies walking in Y-shaped mazes. With this we first conducted...
Organisms use various strategies to cope with fluctuating environmental conditions. In diversified bet-hedging, a single genotype exhibits phenotypic heterogeneity the expectation that some individuals will survive transient selective pressures. To date, empirical evidence for bet-hedging is scarce. Here, we observe individual Drosophila melanogaster flies exhibit striking variation in light- and temperature-preference behaviors. With modeling approach combines real world weather climate...
Non-genetic individuality in behavior, also termed intragenotypic variability, has been observed across many different organisms. A potential cause of variability is sensitivity to minute environmental differences during development, even as major parameters are kept constant. Animal enrichment paradigms often include the addition diversity, whether form social interaction, novel objects, or exploratory opportunities. Enrichment could plausibly affect opposing ways: it an increase due...
Abstract Fluctuating environmental pressures can challenge organisms by repeatedly shifting the optimum phenotype. Two contrasting evolutionary strategies to cope with these fluctuations are 1) evolution of mean phenotype follow (adaptive tracking) or 2) diversifying phenotypes so that at least some individuals have high fitness in current fluctuation (bet-hedging). Bet-hedging could underlie stable differences behavior present even when genotype and environment held constant. Instead being...
Abstract Non-genetic individuality in behavior, also termed intragenotypic variability, has been observed across many different organisms. A potential cause of variability is sensitivity to minute environmental differences during development, even as major parameters are kept constant. Animal enrichment paradigms often include the addition diversity, whether form social interaction, novel objects, or exploratory opportunities. Enrichment could plausibly affect opposing ways: it an increase...
Drosophila melanogaster is able to thrive in harsh northern climates through adaptations life-history traits and physiological mechanisms that allow for survival the winter. We examined genetic basis of natural variation one such trait, female virgin egg retention, which was previously shown vary clinally seasonally. To further our understanding evolution we performed a genome-wide association study (GWAS) using sequenced Genetic Reference Panel (DGRP) mapping population. found 29 single...
We used a next-generation sequencing platform to characterize microbial cell-free DNA (mcfDNA) in plasma samples from patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HCT). In this observational study, we sought mcfDNA order explore its potential association with the immunologic complications of transplantation. compared serially collected patient healthy control subjects. observed changes total burden after transplantation, which was most striking during early...
Drosophila melanogaster egg production, a proxy for fecundity, is an extensively studied life-history trait with strong genetic basis. As eggs develop into larvae and adults, space resource constraints can put pressure on the developing offspring, leading to decrease in viability, body size, lifespan. Our goal was map basis of offspring number weight under restriction standard laboratory vial. We screened 143 lines from Genetic Reference Panel numbers weights create "offspring index" that...
ABSTRACT Sequencing of plasma microbial cell-free DNA (mcfDNA) has gained increased acceptance as a valuable adjunct to standard-of-care testing for diagnosis infections throughout the body. Here we report analytical and clinical validation novel application mcfDNA sequencing, non-invasive detection seven common antimicrobial resistance (AMR) genetic markers in 18 important pathogens with potential harbor these markers. The AMR include SCC mec , mecA mecC methicillin, vanA vanB vancomycin,...
Sequencing of plasma microbial cell-free DNA (mcfDNA) has gained increased acceptance as a valuable adjunct to standard-of-care testing for diagnosis infections throughout the body. Here, we report analytical and clinical validation novel application mcfDNA sequencing, non-invasive detection seven common antimicrobial resistance (AMR) genetic markers in 18 important pathogens. The AMR include SCC
ABSTRACT Congenital disorders of glycosylation (CDG) comprise a class inborn errors metabolism resulting from pathogenic variants in genes coding for enzymes involved the asparagine-linked proteins. Unexpectedly to date, no CDG has been described ALG10 , encoding alpha-1,2-glucosyltransferase catalyzing final step lipid-linked oligosaccharide biosynthesis. Genome-wide association studies (GWAS) human traits UK Biobank revealed significant SNP associations with short sleep duration, reduced...
Abstract Individual animals behave differently from each other. This variability is a component of personality and arises even when genetics environment are held constant. Discovering the biological mechanisms underlying behavioral depends on efficiently measuring individual bias, requirement that facilitated by automated, high-throughput experiments. We compiled large data set locomotor behavior measures, acquired over 183,000 fruit flies walking in Y-shaped mazes. With this we first...
Abstract Drosophila melanogaster egg production, a proxy for fecundity, is an extensively studied life-history trait with strong genetic basis. As eggs develop into larvae and adults, space resource constraints can put pressure on the developing offspring, leading to decrease in viability, body size, lifespan. Our goal was map basis of offspring number weight under restriction standard laboratory vial. We screened 143 lines from Genetic Reference Panel numbers weights create ‘offspring...