A5031002064- DNA Repair Mechanisms
- DNA and Nucleic Acid Chemistry
- Biochemical and Molecular Research
- Long-Term Effects of COVID-19
- Neonatal Health and Biochemistry
- Epigenetics and DNA Methylation
- Blood groups and transfusion
- Genomics and Chromatin Dynamics
- RNA and protein synthesis mechanisms
- Hemoglobinopathies and Related Disorders
- Clinical Laboratory Practices and Quality Control
- Analytical chemistry methods development
- COVID-19 and Mental Health
- CRISPR and Genetic Engineering
- COVID-19 Clinical Research Studies
New York University
1996-2023
NYU Langone Health
2023
Wesleyan University
1996
University Medical Center
1996
There is clinical equipoise for COVID-19 convalescent plasma (CCP) use in patients hospitalized with COVID-19.To determine the safety and efficacy of CCP compared placebo receiving noninvasive supplemental oxygen.CONTAIN COVID-19, a randomized, double-blind, placebo-controlled trial adults was conducted at 21 US hospitals from April 17, 2020, to March 15, 2021. The enrolled 941 participants who were 3 or less days presented 7 after symptom onset required oxygen supplementation.A unit...
We previously purified a bovine pyrimidine hydrate-thymine glycol DNA glycosylase/AP lyase. The amino acid sequence of tryptic peptides was homologous to Escherichia coli endonuclease III, theoretical proteins Saccharomyces cerevisiae and Caenorhabditis elegans, the translated sequences rat human 3′-expressed tags (3′-ESTs) (Hilbert, T. P., Boorstein, R. J., Kung, H. C., Bolton, P. H., Xing, D., Cunningham, Teebor, G. W. (1996) Biochemistry 35, 2505-2511). Now 3′-EST used isolate cDNA clone...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTUV-induced pyrimidine hydrates in DNA are repaired by bacterial and mammalian glycosylase activitiesRobert J. Boorstein, Timothy P. Hilbert, Jean Cadet, Richard Cunningham, George W. TeeborCite this: Biochemistry 1989, 28, 15, 6164–6170Publication Date (Print):July 25, 1989Publication History Published online1 May 2002Published inissue 25 July 1989https://doi.org/10.1021/bi00441a007Request reuse permissionsArticle Views94Altmetric-Citations76LEARN...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFormation and stability of repairable pyrimidine photohydrates in DNARobert J. Boorstein, Timothy P. Hilbert, Richard Cunningham, George W. TeeborCite this: Biochemistry 1990, 29, 46, 10455–10460Publication Date (Print):November 1, 1990Publication History Published online1 May 2002Published inissue 1 November 1990https://pubs.acs.org/doi/10.1021/bi00498a004https://doi.org/10.1021/bi00498a004research-articleACS PublicationsRequest reuse...
We purified a homologue of the Escherichia coli DNA repair enzyme endonuclease III 5000-fold from calf thymus which, like III, demonstrates DNA-glycosylase activity against pyrimidine hydrates and thymine glycol AP lyase (DNA strand cleavage at sites via β-elimination). The functional similarity between enzymes suggested strategy for definitive identification bovine protein based on nature its enzyme−substrate (ES) intermediate. Prokaryotic glycosylase/AP lyases function through N-acylimine...
Patients with sickle cell disease (SCD) frequently undergo prophylactic red blood (RBC) exchange transfusion and simple (RCE/T) to prevent complications of disease, such as stroke. These treatment procedures are performed a target hemoglobin S (HbS) ≤30%, or goal maintaining an HbS level <30% immediately prior the next transfusion. However, there is lack evidence-based instructions for how perform RCE/T in way that will result value between treatments.To determine whether targets...