A5073728648- Cutaneous Melanoma Detection and Management
- Cutaneous lymphoproliferative disorders research
- Lymphoma Diagnosis and Treatment
- Melanoma and MAPK Pathways
- Nonmelanoma Skin Cancer Studies
- Mechanical Circulatory Support Devices
- Sarcoma Diagnosis and Treatment
- Fungal Infections and Studies
- Chronic Lymphocytic Leukemia Research
- Histiocytic Disorders and Treatments
- Cancer and Skin Lesions
- Hemoglobinopathies and Related Disorders
- Hematological disorders and diagnostics
- Eosinophilic Disorders and Syndromes
- CNS Lymphoma Diagnosis and Treatment
- Cerebrovascular and genetic disorders
- CAR-T cell therapy research
- Cancer Genomics and Diagnostics
- Soft tissue tumor case studies
- Polyomavirus and related diseases
- Cardiac Structural Anomalies and Repair
- Genetic Neurodegenerative Diseases
- Epigenetics and DNA Methylation
- Genetic and rare skin diseases.
- Blood transfusion and management
University of Edinburgh
2024
Advanced Dermatology & Cosmetic Surgery
2021-2024
Advanced Dermatology
2021-2023
Texas Medical Center
2020
The University of Texas Southwestern Medical Center
2019
Southwestern Medical Center
2019
NYU Langone Health
2018-2019
Montefiore Medical Center
2015-2018
Albert Einstein College of Medicine
2016-2018
Columbia University Irving Medical Center
2018
Aims Plasmablastic plasma cell myeloma ( PPCM ) is a rare morphological presentation of multiple myeloma, and can resemble plasmablastic lymphoma PBL ), human immunodeficiency virus HIV )‐related lymphoid neoplasm, morphologically immunophenotypically. The aim this study was to retrospectively search for factors that could help differentiate these two entities. Methods results We used clinical looking glass , data mining tool, identify patients with diagnosis either or CD 117 test performed....
A 19-year-old Caucasian female with adult-onset Still disease (AOSD) presented for evaluation of an acute clinical decompensation and atypical annular papules plaques purpura on the lower extremities. punch biopsy demonstrated histiocytes engulfed degenerated erythrocytes lymphocytes, consistent hemophagocytic lymphohistiocytosis (HLH). HLH, clinically referred to as macrophage activation syndrome, is a rare complication AOSD life-threatening. Relevant clinical, laboratory, histologic...
Abstract: Comparing studies of molecular ancillary diagnostic tests for difficult-to-diagnose cutaneous melanocytic neoplasms presents a methodological challenge, given the disparate ways accuracy metrics are calculated. A recent report by Boothby-Shoemaker et al investigating real-world 23-gene expression profile (23-GEP) test highlights this difficulty, reporting lower than previously observed. However, their calculation method—with indeterminate results defined as either false positive or...
Patients with skin lesions suspicious for cancer or atypical melanocytic nevi of uncertain malignant potential often present to dermatologists, who may have variable dermoscopy triage clinical experience.
We report a case in which 43-year-old African American male with medical history of sickle cell disease (SCD) presented nonhealing ulcer. Biopsy revealed features livedoid vasculopathy. Previously, vasculopathy had only been described patient trait, but never SCD. Livedoid most commonly affects the distal lower extremities and is characterized by irregular, punched-out, painful ulcers that heal stellate white scars atrophie blanche. Histologically, it reveals segmental hyalinizing vessels,...
A collision tumor is defined as two histologically distinct types identified at the same anatomic site. Hematolymphoid proliferative disorders (HLPDs), which coincide with non-hematological neoplasms, can mimic an immune response and easily be overlooked reaction to a solid organ neoplasm, especially when low grade. In order avoid delay in diagnosis of HLPD during workup for we cohort 100 cases initial treatment or vice versa. Among tumors, most common neoplasms associated were from colon...
Treatment plans for cutaneous melanoma are based upon individual risk of recurrence. Decisions made post-diagnosis include recommendation a sentinel lymph node biopsy (SLNB), followed by management decisions such as surveillance, frequency follow-up, and interdisciplinary consultations including possible adjuvant therapy use. These have traditionally been guided clinicopathologic factors, but discordance exists, substantial number deaths occur in patients diagnosed with disease considered to...
Medical school curricula limit students' exposure to pathology practice while subspecialty training programs require residents apply for fellowships as early the end of their first year training. Thus, limited creates significant confusion and anxiety, often making fellowship application process premature. Additionally, focus on in order acquire a adds initial lack emphasis general We prepared voluntary online survey with questions developed through groups advice from an expert design...
Porokeratosis and angiokeratomas are both seen in the setting of chronic graft-vs.-host disease (GVHD), but rarely occur together. We present a case patient with lichen planus-like (LPL) sclerodermatous GVHD manifesting after allogeneic bone marrow transplant concomitant eruptive porokeratosis.
Abstract: Chronic myelomonocytic leukemia (CMML) is a rare hematopoietic stem cell neoplasm. Indeterminate dendritic neoplasm (IDCN) an extraordinarily histiocytosis that may manifest secondarily to CMML. A 75-year-old man with 2-year history of CMML presented for multiple cutaneous lesions on his head and neck. Biopsy results yielded dense diffuse infiltrate large pleomorphic cells, which were positive CD1a, S100, CD56 weak positivity CD43 CD68. Given CMML, the patient was diagnosed IDCN....
Classically, secondary syphilis presents as a generalized nonpruritic papulosquamous eruption, which may include the palms and soles, typically occuring 3 to 10 weeks after initial spirochete inoculation.1,2 Numerous unusual presentations have been reported, including but not limited to, annular or figurative plaques, “moth-eaten” alopecia, polymorphic papules, granulomatous nodules, crusted nail changes.3 Typical histologic findings superficial deep perivascular lymphocytic infiltrate with...
<h3>Background</h3> Currently, FDA-approved adjuvant immunotherapies are not approved for patients with stage IB–IIA cutaneous melanoma (CM), and this group is recommended asymptomatic surveillance imaging.<sup>1</sup> However, IB-IIA CM have up to 20–38% recurrence rates account approximately one-quarter of all CM.<sup>2 3</sup> Thus, additional methods identify which in at the highest risk needed so that clinicians can recommend risk-appropriate treatment options. The 31-gene expression...
Patients with sickle cell disease (SCD) frequently undergo prophylactic red blood (RBC) exchange transfusion and simple (RCE/T) to prevent complications of disease, such as stroke. These treatment procedures are performed a target hemoglobin S (HbS) ≤30%, or goal maintaining an HbS level <30% immediately prior the next transfusion. However, there is lack evidence-based instructions for how perform RCE/T in way that will result value between treatments.To determine whether targets...
The relationship between the presence of specific T-cell receptor (TCR) gene rearrangements and clinical stage in mycosis fungoides (MF) has not been studied. We analysed a cohort patients with diagnosis MF to determine different types TCR present their disease stage.A retrospective chart review was used select who had skin biopsy positive rearrangement study either blood or tissue at least 2 years follow-up.43 were identified divided into two groups. first group consisted 23 early (IA-IIA)...