A5059942412- Bone Metabolism and Diseases
- Vitamin D Research Studies
- Bone health and osteoporosis research
- Peripheral Neuropathies and Disorders
- Nephrotoxicity and Medicinal Plants
- Axon Guidance and Neuronal Signaling
- Mercury impact and mitigation studies
- Autophagy in Disease and Therapy
- Heavy Metal Exposure and Toxicity
- Redox biology and oxidative stress
- Silymarin and Mushroom Poisoning
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Trace Elements in Health
- Drug-Induced Hepatotoxicity and Protection
- RNA modifications and cancer
- Environmental Toxicology and Ecotoxicology
- Selenium in Biological Systems
- Vasculitis and related conditions
- Biomarkers in Disease Mechanisms
- Ferroptosis and cancer prognosis
Xiangya Hospital Central South University
2024
Central South University
2024
Shandong University
2022-2023
Background: Aging and oxidative stress are considered to be the proximal culprits of postmenopausal osteoporosis. Eldecalcitol (ED-71), a new active vitamin D derivative, has shown good therapeutic effect on different types osteoporosis, but mechanism is unclear. This study focused exploring whether ED-71 could prevent bone loss in osteoporosis by regulating cell senescence mesenchymal stem cells (BMSCs), explaining its specific action. Materials methods: An ovariectomized (OVX) rat model...
Long-term glucocorticoid- usage can lead to glucocorticoid-induced osteoporosis (GIOP). The study focused on the preventative effects of a novel active vitamin D3 analog, eldecalcitol (ED-71), against GIOP and explored underlying molecular mechanisms.Intraperitoneal injection methylprednisolone (MPED) or dexamethasone (DEX) induced model within C57BL/6 mice in vivo. Simultaneously, ED-71 was orally supplemented. Bone histological alterations, microstructure parameters, bone formation rates,...
Peroxiredoxin 1 (Prdx1), a vital antioxidant enzyme, has been proven to play an important role in the occurrence and development of cancers, but its effects on oral squamous cell carcinoma (OSCC) remain unclear. Here, we performed bioinformatics analysis immunohistochemical (IHC) staining confirm that Prdx1 was higher OSCC tissues than normal tissues. Consistently, RT-PCR Western blot showed elevated expression lines compared human keratinocytes (HOK), which could be knockdown by small...
The remission rate of myeloperoxidase (MPO)-antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) patients who received standard induction therapy is far from satisfactory. Improving the MPO-AAV essential. Hydroxychloroquine (HCQ), one classic antimalarial drugs, has been widely used in various autoimmune rheumatic diseases. This retrospective observational cohort study aimed to evaluate efficacy and safety HCQ during treatment for MPO-AAV.