A5100418151- Sarcoma Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Renal cell carcinoma treatment
- Lung Cancer Treatments and Mutations
- Pulmonary Hypertension Research and Treatments
- Ear and Head Tumors
- Respiratory Support and Mechanisms
- RNA modifications and cancer
- Vascular Tumors and Angiosarcomas
- Lung Cancer Research Studies
- Renal and related cancers
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Prostate Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Gastric Cancer Management and Outcomes
- Lung Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Acute Kidney Injury Research
- Renal Diseases and Glomerulopathies
- Prostate Cancer Treatment and Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Neonatal Respiratory Health Research
- Bone Tumor Diagnosis and Treatments
- Musculoskeletal synovial abnormalities and treatments
- Inflammatory Biomarkers in Disease Prognosis
Wuxi People's Hospital
2024-2025
Shanghai Children's Medical Center
2025
Shanghai Jiao Tong University
2025
Tianjin Medical University
2025
Tianjin Medical University General Hospital
2025
Augusta University
2019-2024
University of Utah
2014-2024
ARUP Laboratories (United States)
2022-2024
West China Medical Center of Sichuan University
2023
Qingdao University
2023
Colon cancer (CC) is a disease with high incidence and mortality rate. The interaction between epithelial-mesenchymal transition (EMT) immune status has important clinical significance. We aim to identify EMT-immune-related prognostic biomarkers in colon cancer. GEO2R GEPIA 2.0 were utilized calculate the differential expression genes CC normal mucosa. Immport, InnateDB EMTome databases used define genes. conducted batch analysis by TCGA data. patterns verified multiple datasets lab...
To explore the clinical characteristics and risk factors for adverse outcomes in patients with Sjögren's Syndrome-associated pulmonary arterial hypertension (SS-PAH). A retrospective analysis was conducted on SS-PAH diagnosed by right heart catheterization (RHC) between March 2013 2024 across four Chinese medical centers. Patients were categorized into primary (pSS-PAH) overlap SS-PAH, based presence of additional autoimmune diseases. We compared demographic data, echocardiographic...
We retrospectively examined progression-free survival (PFS) and response by ALK fluorescence in-situ hybridization (FISH) status in patients with advanced immunohistochemistry (IHC)-positive non-small-cell lung cancer (NSCLC) the ALEX study.
LBA9008 Background: Alectinib, a TKI targeting ALK, has shown robust efficacy in crizotinib-naïve/resistant ALK+ NSCLC. J-ALEX showed superiority of alectinib 300mg BID vs crizotinib Japanese pts with crizotinib-naïve NSCLC (progression-free survival [PFS] HR 0.34, p<0.0001). We report primary results from the ALEX study first-line 600mg advanced (NCT02075840). Methods: This open-label randomized multicenter phase III enrolled stage IIIB/IV NSCLC, determined by central IHC testing....
Interferon-gamma (IFNG) has profound impacts on tumor-immune interaction and is of great clinical significance for multiple cancers. Exploring the role IFNG in glioblastoma (GBM) may optimize current treatment paradigm this disease. Here, multi-dimensional data 429 GBM samples were collected. Various bioinformatics algorithms employed to establish a gene signature that characterizes immunological features, genomic alterations, characteristics associated with response. In way, novel...
The satisfactory prognostic indicator of gastric cancer (GC) patients after surgery is still lacking. Perioperative plasma extracellular vesicular programmed cell death ligand-1 (ePD-L1) has been demonstrated as a potential prognosis biomarker in many types cancers. value postoperative ePD-L1 not characterized.We evaluated the preoperative, and change ePD-L1, well soluble PD-L1, short-term survival GC surgery. Kaplan-Meier model Cox proportional hazards models for both univariate...
Acute lung injury (ALI) or its aggravated stage acute respiratory distress syndrome (ARDS) is a common severe clinical in intensive care unit, may lead to life-threatening form of failure, resulting high mortality up 30–40% most studies. Nanotechnology-mediated anti-inflammatory therapy an emerging novel strategy for the treatment ALI, has been demonstrated with unique advantages solving dilemma ALI drug therapy. Artesunate (ART), derivative artemisinin, reported have effects. Therefore,...
To evaluate both left and right ventricular (LV RV) function in patients with pulmonary arterial hypertension (PAH) using cardiac magnetic resonance tissue-tracking (CMR-TT) technology explore its clinical value. Methods: A total of 79 participants (including 47 PAH 32 healthy controls) underwent imaging (CMRI) a short-axis balanced steady-state free precession (SSFP) sequence. The biventricular parameters strain were obtained by postprocessing CVI42 software. comparative analysis was...
Peroxiredoxin 1 (Prdx1), a vital antioxidant enzyme, has been proven to play an important role in the occurrence and development of cancers, but its effects on oral squamous cell carcinoma (OSCC) remain unclear. Here, we performed bioinformatics analysis immunohistochemical (IHC) staining confirm that Prdx1 was higher OSCC tissues than normal tissues. Consistently, RT-PCR Western blot showed elevated expression lines compared human keratinocytes (HOK), which could be knockdown by small...
Background Although European Society of Urogenital Radiology proposed the potential multiparametric magnetic resonance imaging (MP-MRI) as a tool in diagnostic pathway for prostate cancer (PCa) and published unified scoring system named Prostate Imaging Reporting Data System (PI-RADS version 1), these still need to be validated by real-life studies. Objective To evaluate role MP-MRI detection prediction PCa. Methods Patients with clinical suspicion PCa who underwent prebiopsy from 2002 2009...
IntroductionGenomic and morphologic heterogeneity in clear cell renal carcinoma (ccRCC) presents a barrier to prognostication treatment decisions. Data from pathology are used with clinical markers predict disease progression after nephrectomy. However, determining the risk of cancer recurrence, survival metastatic remains challenging. Recently, analysis histologic growth patterns (HGP) ccRCC revealed promising associations outcomes.MethodsTo investigate whether HGPs can be overall (OS)...
An imperative need for better management strategies to improve the survival in patients with undifferentiated pleomorphic sarcoma (UPS).The retrospective analysis of clinicopathological data 166 UPS patients, who have undergone surgical treatment our hospital, was carried out from January 2005 2018. Cox regression model and Kaplan-Meier method were employed identify relevant factors affecting rate local recurrence (LR), distant metastasis (DM), overall (OS) via univariate multivariate...
Abstract Objectives To investigate the prognostic impact and pathophysiological characteristics of fragmented QRS complex (fQRS) on patients with CTD-associated pulmonary arterial hypertension (CTD-PAH). Methods This was a multicentre retrospective study recruiting 141 CTD-PAH diagnosed by right heart catheterization (114 cases in discovery cohort 27 validation cohort). fQRS ST-T change were detected conventional 12-lead ECG. Patients followed up every 3 months to update their status primary...
To allow visualization of macrophage-rich and miniature-sized atheromas by magnetic resonance (MR) imaging, we have converted low-density lipoprotein (LDL) into MR-active nanoparticles via the intercalation a 1,4,7,10-tetraazacyclodecane-1,4,7-triacetic acid (DO3A) derivative subsequent coordination reaction with Gd3+. After careful removal nonchelated Gd3+, an LDL (Gd3+-LDL) remarkably high payload Gd3+ (in excess 200 atoms per particle) relaxivity (r1 = 20.1 s–1 mM–1 or 4040 LDL) was...
Background: Thyroid cancer is a common malignant tumor of the endocrine system that has shown increased incidence in recent decades. We explored relationship between tumor-infiltrating immune cell classification and prognosis thyroid carcinoma. Methods: RNA-seq, SNV, copy number variance (CNV), methylation data for were downloaded from TCGA dataset. ssGSEA was used to calculate pathway scores. Clustering conducted using ConsensusClusterPlus. Immune infiltration assessed ESTIMATE CIBERSORT....
// Ting Liu 1, * , Abulajiang Gulinaer Xiaoli Shi 1 Feng Wang 2 Hengqing An Wenli Cui and Qiaoxin Li Department of Pathology, The First Affiliated Hospital, Xinjiang Medical University, Urumqi, China Urology, These authors have contributed equally to this work should be considered co-first Correspondence to: Li, email: liqiaoxin2141@aliyun.com Keywords: case-control study, prostate cancer, genetic susceptibility, PI3K/AKT/mTOR pathway, polymorphism Abbreviations: SNPs: single nucleotide...
Children's injuries from traffic accidents have been identified as a global public health issue. Child restraint system (CRS) is useful tool for lowering the risk of injury to children. Nevertheless, CRS usage really low in China. The goal current study was investigate use after legislation revised China and explore influencing factors based on Information, Motivation, Behavioral Skills model (IMB).