A5041344197- Wound Healing and Treatments
- Diabetic Foot Ulcer Assessment and Management
- Pressure Ulcer Prevention and Management
- Diagnosis and Treatment of Venous Diseases
- Reconstructive Surgery and Microvascular Techniques
- Surgical Sutures and Adhesives
- Tissue Engineering and Regenerative Medicine
- Corneal Surgery and Treatments
- Burn Injury Management and Outcomes
- Glycosylation and Glycoproteins Research
- Medical and Biological Ozone Research
- Sepsis Diagnosis and Treatment
- Healthcare Technology and Patient Monitoring
- Spinal Cord Injury Research
- Balance, Gait, and Falls Prevention
- Cellular transport and secretion
- Protein Kinase Regulation and GTPase Signaling
- Surgical site infection prevention
- Infectious Aortic and Vascular Conditions
- Vascular Procedures and Complications
- Endodontics and Root Canal Treatments
- Leech Biology and Applications
- Electrospun Nanofibers in Biomedical Applications
- Peripheral Artery Disease Management
- Autoimmune and Inflammatory Disorders
Western University of Health Sciences
2019-2025
Duke University
2014-2025
Restorix Health
2023-2025
Undersea and Hyperbaric Medical Society
2023-2025
University School
2021-2024
Nia Association
2021-2023
Orthopedic Specialty Hospital
2021-2022
Healthwise
2021
Mayo Clinic in Arizona
2021
Arizona Research Center
2021
A randomised, controlled multicentre clinical trial was conducted at 14 wound care centres in the United States to confirm efficacy of dehydrated human amnion/chorion membrane allograft (dHACM) for treatment chronic lower extremity ulcers persons with diabetes. Patients a ulcer least 4 weeks duration were entered into 2‐week study run‐in phase and treated alginate dressings appropriate offloading. Those less than or equal 25% closure after randomly assigned receive weekly dHACM application...
There are currently over 80 biomaterials derived from autologous, allogeneic, synthetic and xenogeneic sources, or a combination of any all these types materials, available for soft-tissue coverage to effect wound closure. Often generically referred as cellular and/or tissue-based products (CTPs), they manufactured under various trade names marketed variety indications.
The aim of this study was to determine the safety and effectiveness dehydrated human umbilical cord allograft (EpiCord) compared with alginate wound dressings for treatment chronic, non‐healing diabetic foot ulcers (DFU). A multicentre, randomised, controlled, clinical trial conducted at 11 centres in United States. Individuals a confirmed diagnosis Type 1 or 2 diabetes presenting 15 cm ulcer located below ankle that had been persisting least 30 days were eligible 14‐day run‐in phase. After...
To evaluate the cost-effectiveness and budget impact of using standard care (no advanced treatment, NAT) compared with an treatment (AT), dehydrated human amnion/chorion membrane (DHACM), when following parameters for use (FPFU) in treating lower extremity diabetic ulcers (LEDUs).We analysed a retrospective cohort Medicare patients (2015-2019) to generate four propensity-matched cohorts LEDU episodes. Outcomes DHACM NAT, such as amputations, healthcare utilisation were tracked from claims...
Objective: To evaluate the cost-effectiveness of dehydrated human amnion/chorion membrane (DHACM) in Medicare enrolees who developed a venous leg ulcer (VLU). Method: This economic evaluation used four-state Markov model to simulate disease progression VLUs for patients receiving advanced treatment (AT) with DHACM or no (NAT) over three-year time horizon from US perspective. treatments were assessed when following parameters use (FPFU), whereby applications initiated 30–45 days after initial...
Abstract Objective Develop and evaluate an automated case detection response triggering system to monitor patients every 5 min identify early signs of physiologic deterioration. Materials methods A 2-year prospective, observational study at a large level 1 trauma center. All admitted 33-bed medical oncology floor (A) non-intensive care unit (ICU) surgical (B) were monitored. During the intervention year, pager alerts deterioration automatically sent charge nurses along with access graphical...
Objective: To evaluate large propensity-matched cohorts to assess outcomes in patients receiving advanced treatment (AT) with skin substitutes for lower extremity diabetic ulcers (LEDUs) versus no AT (NAT) the management of LEDUs. Method: The Medicare Limited Dataset (1 October 2015 through 2 2018) were used retrospectively analyse people care a LEDU treated or NAT (propensity-matched Group 1). Analysis included major and minor amputations, emergency department (ED) visits hospital...
Journal of Wound CareVol. 34, No. 1 CAMPs Summit 2025Updated Local Coverage Determinations: their impact on wound careWilliam H TettelbachWilliam TettelbachChief Medical Officer, RestorixHealth, Metairie, LA, US; Adjunct Assistant Professor, Duke University School Medicine, Undersea and Hyperbaric Medicine; Western Health Sciences, Podiatric Medicine Surgery, Salt Lake City, Utah, USWilliam TettelbachPublished Online:11 Jan 2025https://doi.org/10.12968/jowc.2024.0435AboutSectionsView...
Lower extremity diabetic ulcers (LEDUs) are a common, high-morbidity complication of diabetes, frequently leading to infections, hospitalisations and emergency department visits. This case study examines the treatment effectiveness novel wound care approach in 57-year-old female patient with hard-to-heal LEDU (a foot ulcer left lower extremity) complicated by poorly controlled diabetes (glycated haemoglobin A1c: 13%). Initially, standard (SoC) practices, including alginate dressings,...
Journal of Wound CareEarly view Roundtable ReportFree AccessAn advanced diagnostic imaging tool to enhance clinical decision-making and wound healingThomas Serena, William H Tettelbach, Andrew Rader, Amy Couch, Naz Wahab, Misael Alonso, Dan Kapp, Martha Kelso, Martin L Johnson, Marcus GitterleThomas SerenaCorresponding author email: E-mail Address: [email protected]MD, FACS, FACHM, MAPWCA, CEO Medical Director SerenaGroup Inc. Research Foundation, US, TettelbachMD, FACP, FIDSA, FUHM, Chief...
Objective: To evaluate the impact of Medicare’s future effective Local Coverage Determination (LCD) for cellular, acellular and matrix-like products (CAMPs), which, while informed by a literature review expert input, was finalised without incorporating detailed statistical or cost analysis its projected clinical economic across diverse wound care delivery settings (e.g., hospital-affiliated, private practice, post-acute care). This focuses on consequences Medicare beneficiaries with chronic...
To determine the role of debridement when patients are using placental-derived allografts (PDAs), data from two prospective, multicentre, randomised controlled trials (RCTs) were evaluated for quality or adequacy on diabetic foot ulcers (DFUs) treated with PDAs. Results compared real-world findings via a retrospective analysis 2015-2019 Medicare claims DFUs.Debridement in prospective RCTs was adjudicated by three blinded wound care specialists. Treatments included PDAs, dehydrated human...
To retrospectively evaluate the comorbidities, treatment patterns and outcomes of Medicare enrolees who developed venous leg ulcers (VLUs).Medicare Limited Data Standard Analytic Hospital Inpatient Outpatient Department Files were used to follow patients received medical care for a VLU between 1 October 2015 2 2019. Patients diagnosed with chronic insufficiency (CVI) propensity matched into four groups based on their regimen. Episode claims document demographics, comorbidities treatments...
Melanoma growth stimulatory activity (MGSA/GRO), a cyto‐kine originally characterized as an autocrine factor for melanoma cells, is highly chemotactic neutrophils and releases neutrophil elastase well other matrix‐degrading enzymes. Previous work has demonstrated the presence of MGSA/GRO in melanocytic lesions epidermal keratinocytes non‐lesional skin psoriatic scale. Herein, localization was examined variety human exhibiting proliferative and/or differentiative disorders using...
Abstract Despite the health care community's best efforts, 20% of diabetic patients who develop a foot ulcer will require some form amputation. Those undergoing major lower extremity amputation risk an increase in their five‐year mortality rate to 56.6%, which is comparable or higher than many forms cancer. Given this perspective, quality measures need be considered at each patient inflection point drive increased compliance with practices order redirect whose therapies fail. Medicare...
Statistical interpretation of data collected in a randomised controlled trial (RCT) is conducted on the intention‐to‐treat (ITT) and/or per‐protocol (PP) study populations. ITT analysis comparison treatment groups including all patients as originally allocated after randomisation regardless if was initiated or completed. PP only those who completed allocated, although it often criticised because its potential to instil bias. A previous report from an RCT evaluate efficacy dehydrated human...