A5002786211- Wound Healing and Treatments
- Diabetic Foot Ulcer Assessment and Management
- Pressure Ulcer Prevention and Management
- Diagnosis and Treatment of Venous Diseases
- Surgical site infection prevention
- Surgical Sutures and Adhesives
- Corneal Surgery and Treatments
- Clinical practice guidelines implementation
- Cardiac, Anesthesia and Surgical Outcomes
- Folate and B Vitamins Research
- Periodontal Regeneration and Treatments
- Peripheral Artery Disease Management
- Mesenchymal stem cell research
- Laser Applications in Dentistry and Medicine
- Planarian Biology and Electrostimulation
- Venous Thromboembolism Diagnosis and Management
- Connexins and lens biology
- Oral and gingival health research
- Autoimmune Bullous Skin Diseases
- COVID-19 Impact on Reproduction
- Reconstructive Surgery and Microvascular Techniques
- Burn Injury Management and Outcomes
- Silk-based biomaterials and applications
- Parathyroid Disorders and Treatments
- Biomedical Ethics and Regulation
SerenaGroup Research Institute
2016-2025
University of Utah
2025
William & Mary
2023
Christie's
2014-2017
Johnson & Johnson (United Kingdom)
2017
In-Q-Tel
2014-2017
American College of Surgeons
2014-2016
Augusta University
2016
University of Georgia
2016
Professional Education and Research Institute
2016
Abstract Our purpose was to compare healing characteristics of diabetic foot ulcers treated with dehydrated human amniotic membrane allografts ( EpiFix ®, MiMedx , Kennesaw, GA ) versus standard care. An IRB ‐approved, prospective, randomised, single‐centre clinical trial performed. Included were patients a ulcer at least 4‐week duration without infection having adequate arterial perfusion. Patients randomised receive care alone or the addition . Wound size reduction and rates complete after...
Diabetic foot ulcers are a significant health care problem. Complications of leading cause hospitalization and amputation in patients with diabetes mellitus. In response to request from the Wound Healing Society, panel advisers, including physicians academia private practice, nurses, podiatrist, pedorthist, representative industry, was selected develop guidelines for treatment diabetic lower extremity. The approach used similar that by Venous Ulcer Panel, also convened at Society. Those were...
An advisory panel of academicians, private practice physicians, podiatrists, nurse clinicians, research nurses, industrial scientists, and an epidemiologist was chosen to develop guidelines for the treatment venous ulcers lower extremity. Previous guidelines, meta-analyses, PubMed, MEDLINE, EMBASE, The Cochrane Database Systematic Reviews, recent review articles ulcer treatment, Medicare/CMS consensus usual chronic wounds were all reviewed evidence. Guidelines formulated, underlying...
Abstract This cross‐sectional international survey assessed patients’ perceptions of their wound pain. A total 2018 patients (57% female) from 15 different countries with a mean age 68·6 years (SD = 15·4) participated. The wounds were categorised into ten types duration 19·6 months 51·8). For patients, 3361 dressings/compression systems being used, antimicrobials reported most frequently ( n 605). Frequency wound‐related pain was as 32·2%, ‘never’ or ‘rarely’, 31·1%, ‘quite often’ and 36·6%,...
Abstract A prospective, randomised, controlled, parallel group, multi‐centre clinical trial was conducted at three sites to compare the healing effectiveness of treatment chronic lower extremity diabetic ulcers with either weekly applications Apligraf ® (Organogenesis, Inc., Canton, MA ), EpiFix ( MiMedx Group, Marietta, GA or standard wound care collagen‐alginate dressing. The primary study outcome percent change in complete after 4 and 6 weeks treatment. Secondary outcomes included area...
Abstract Advanced therapies such as bioengineered skin substitutes ( BSS ) and dehydrated human amnion/chorion membrane dHACM have been shown to promote healing of chronic diabetic ulcers. An interim analysis data from 60 patients enrolled in a prospective, randomised, controlled, parallel group, multi‐centre clinical trial showed that EpiFix ®, MiMedx Group Inc., Marietta, GA is superior standard wound care SWC (Apligraf®, Organogenesis, Canton, MA achieving complete closure within 4–6...
Venous leg ulcers produce significant clinical and economic burdens on society often require advanced wound therapy. The purpose of this multicenter, randomized, controlled study is to evaluate the safety efficacy one or two applications dehydrated human amnion/chorion membrane allograft multilayer compression therapy vs. alone in treatment venous ulcers. primary outcome was proportion patients achieving 40% closure at 4 weeks. Of 84 participants enrolled, 53 were randomized receive 31...
The aim of this study is to determine if weekly application dehydrated human amnion/chorion membrane allograft reduce time heal more effectively than biweekly for treatment diabetic foot ulcers. This was an institutional review board-approved, registered, prospective, randomised, comparative, non-blinded, single-centre clinical trial. Patients with non-infected ulcers ≥ 4 weeks duration were included the study. They randomised receive or in addition a non-adherent, moist dressing compressive...
Objective: High bacterial load contributes to chronicity of wounds and is diagnosed based on assessment clinical signs symptoms (CSS) infection, but these characteristics are poor predictors burden. Point-of-care fluorescence imaging (FL) MolecuLight i:X can improve identification with high burden (>104 colony-forming unit [CFU]/g). FL detects bacteria, whether planktonic or in biofilm, does not distinguish between the two. In this study, diagnostic accuracy was compared CSS during routine...
A pandemic afflicts the entire world. The highly contagious SARS-CoV-2 virus originated in Wuhan, China late 2019 and rapidly spread across globe. According to World Health Organization (WHO), novel Coronavirus (COVID-19)has infected more than two million people worldwide, causing over 160,000 deaths. Patients with COVID-19 disease present a wide array of symptoms, ranging from mild flu-like complaints life threatening pulmonary cardiac complications. Older patients underlying have an...
Abstract Elevated levels of bacteria, including biofilm, increase the risk chronic wound infection and inhibit healing. Addressing asymptomatic high bacterial loads is challenged by a lack clinical terminology diagnostic tools. This post‐hoc multicenter trial analysis 138 diabetic foot ulcers investigates fluorescence (FL)‐imaging role in detecting biofilm‐encased planktonic bacteria wounds at loads. The sensitivity specificity assessment FL‐imaging were compared across concern (10 4 –10 9...
Background: Allogeneic grafts derived from amnion/chorion are known to be efficacious in healing chronic diabetic foot ulcerations (DFUs). The goal of this study was compare aseptically processed dehydrated human amnion and chorion allograft (dHACA) versus standard care (SOC) facilitating wound closure nonhealing DFUs. Methods: Patients with DFUs treated SOC (off-loading, appropriate debridement, moist care) after a 2-week screening period were randomized either or wound-size-specific dHACA...
Abstract Acellular dermal matrices can successfully heal wounds. This study's goal was to compare clinical outcomes of a novel, open‐structure human reticular acellular dermis matrix ( HR‐ADM ) facilitate wound closure in non‐healing diabetic foot ulcers DFUs versus treated with standard care SOC ). Following 2‐week screening period which were offloading and moist care, patients randomised either alone or plus applied weekly for up 12 weeks. At 6 weeks, the primary outcome time, 65% ‐treated...
Amnion and chorion allografts have shown great promise in healing diabetic foot ulcers (DFUs). Results from an interim analysis of 40 patients demonstrated the accelerated ability a novel aseptically processed, dehydrated human amnion allograft (dHACA). The goal this study was to report on full trial results 80 where dHACA compared with standard care (SOC) achieving wound closure non-healing DFUs. After 2-week screening period, during which DFUs were unsuccessfully treated SOC, randomised...
Objective: Clinical evaluation of signs and symptoms (CSS) infection is imperative to the diagnostic process. However, patients with heavily colonised infected wounds are often asymptomatic, leading poor accuracy. Point-of-care fluorescence imaging rapidly provides information on presence location bacteria. This clinical trial (#NCT03540004) aimed evaluate accuracy when bacterial was used in combination CSS for identifying moderate-to-heavy loads. Methods: Wounds were assessed by study...
Objectives: Perfusion and blood oxygen levels are frequently insufficient in patients with hard-to-heal wounds due to poor circulation, vascular disruption vasoconstriction, reducing the wound's capacity heal. This study aimed investigate effect of topical on healing rates diabetic foot ulcers (DFUs) (i.e., non-responsive over four weeks). Method: multicentre, open-label, community-based randomised clinical trial compared standard care (SOC) or without continuous therapy (TOT) for 12 weeks...
Journal of Wound CareEarly view Roundtable ReportFree AccessAn advanced diagnostic imaging tool to enhance clinical decision-making and wound healingThomas Serena, William H Tettelbach, Andrew Rader, Amy Couch, Naz Wahab, Misael Alonso, Dan Kapp, Martha Kelso, Martin L Johnson, Marcus GitterleThomas SerenaCorresponding author email: E-mail Address: [email protected]MD, FACS, FACHM, MAPWCA, CEO Medical Director SerenaGroup Inc. Research Foundation, US, TettelbachMD, FACP, FIDSA, FUHM, Chief...
Venous leg ulcers can be very hard to heal and represent a significant medical need with no effective therapeutic treatment currently available.In wound edge biopsies from human venous we found striking upregulation of dermal N-cadherin, Zonula Occludens-1 the gap junction protein Connexin43 (Cx43) compared intact skin, in stark contrast down-regulation Cx43 expression seen acute, healing wounds. We targeted these proteins 3T3 fibroblasts evaluate their role healing. Knockdown but not...
It is widely accepted that elevated protease activity (EPA) in chronic wounds impedes healing. However, little progress has occurred quantifying the level of detrimental for The aim this study was to determine relationship between inflammatory and wound healing status, establish EPA above which human neutrophil-derived elastase (HNE) matrix metalloproteases (MMP) activities correlate with nonhealing wounds. Chronic swab samples (n = 290) were collected from four centers across USA measure...
Regulated alteration of connexin expression has been shown to be integral acute wound repair. Downregulation the gap‐junction protein 43 at edge correlated with keratinocyte and fibroblast migration, while abnormal overexpression significantly perturbs healing, as in streptozotocin diabetic rodent impaired healing model. To examine levels 43, addition connexins 26 30, a variety human chronic wounds. Wound‐edge punch biopsies matched control from arm were taken cohort patients venous leg,...
The aim of this multicenter, prospective, observer-blinded, parallel group, randomized controlled trial was to assess the safety and efficacy EDX110, a nitric oxide generating medical device, in treatment diabetic foot ulcers patient group reflecting "real world" clinical practice compared against optimal standard care. Participants were recruited from ten hospital sites multidisciplinary ulcer clinics. full thickness, with an area 25-2,500 mm2 either palpable pedal pulse or ankle brachial...
Underrepresentation of diverse skin tones in medical education and providers' implicit racial bias drives inequities wound care, such as disproportionally poor outcomes for Black patients. Diagnostic indicators (e.g., erythema) can present differently depending on pigmentation. This post hoc analysis 350 chronic wounds from a prospective 14-site clinical trial aimed to determine how the perception signs symptoms infection (CSS) differs by patient tone if fluorescence-imaging offer more...