A5049675019- Metal-Catalyzed Oxygenation Mechanisms
- Various Chemistry Research Topics
- Chemistry and Chemical Engineering
- Microbial bioremediation and biosurfactants
- Genetics, Aging, and Longevity in Model Organisms
- Enzyme Structure and Function
- Tendon Structure and Treatment
- Toxin Mechanisms and Immunotoxins
- Stress Responses and Cortisol
- Electrochemical sensors and biosensors
- Click Chemistry and Applications
- Chemical Safety and Risk Management
- Antimicrobial agents and applications
- Orthopedic Surgery and Rehabilitation
- Chemistry Education and Research
- Mass Spectrometry Techniques and Applications
- SARS-CoV-2 and COVID-19 Research
- Essential Oils and Antimicrobial Activity
- Advanced Drug Delivery Systems
- Heme Oxygenase-1 and Carbon Monoxide
- Adipose Tissue and Metabolism
- RNA Interference and Gene Delivery
- Shoulder Injury and Treatment
- Circadian rhythm and melatonin
- Enzyme Catalysis and Immobilization
Stanford University
2022-2025
Washington University in St. Louis
2023-2024
Barnard College
2021-2023
Abstract Alkanes are the most energy-rich form of carbon and widely dispersed in environment. Their transformation by microbes represents a key step global cycle. Alkane monooxygenase (AlkB), membrane-spanning metalloenzyme, converts straight chain alkanes to alcohols first microbially-mediated degradation alkanes, thereby playing critical role cycling bioremediation oil. AlkB biodiversity is attributed its ability oxidize various lengths, while individual AlkBs target relatively narrow...
ABSTRACT The renin-angiotensin-aldosterone system (RAAS) plays a well-characterized role regulating blood pressure in mammals. Pharmacological and genetic manipulation of the RAAS has been shown to extend lifespan Caenorhabditis elegans, Drosophila rodents, but its mechanism is not well defined. Here, we investigate angiotensin-converting enzyme (ACE) inhibitor drug captopril, which extends worms mice. To mechanism, performed forward screen for captopril-hypersensitive mutants. We identified...
Of the 1.5 million emergency room visits each year in United States due to flexor tendon injuries hand, over 30-40% result peritendinous adhesions which can limit range of motion (ROM) and severely impact an individual's quality life. Adhesions are fibrous scar-like tissues form between adjacent body response injury, inflammation, or during normal healing following surgery. Currently, there is no widespread solution for adhesion prevention delicate space digit while allowing a patient full...
Antibiotics save countless lives each year and have dramatically improved human health outcomes since their introduction in the 20th century. Unfortunately, bacteria are now developing resistance to antibiotics at an alarming rate, with many new strains of "superbugs" showing simultaneous multiple classes antibiotics. To mitigate global burden antimicrobial resistance, we must develop that broadly effective, safe, highly stable enable access. In this manuscript, report development...
Abstract Messenger RNA (mRNA) delivered in lipid nanoparticles (LNPs) rose to the forefront of vaccine candidates during COVID-19 pandemic due part scalability, adaptability, and potency. Yet there remain critical areas for improvements these vaccines durability breadth humoral responses. In this work, we explore a modular strategy target mRNA/LNPs antigen presenting cells with an injectable polymer-nanoparticle (PNP) hydrogel depot technology which recruits key immune forms immunological...
Here we present a hands-on module for high school students to explore the chemistry of henna dye. This lesson is affordable, accessible, adaptable, and engaging students. In this lesson, are shown how paste derived from shrub, discuss chemical structure main dye component lawsone (2-hydroxy-1,4-napthoquinone), apply their skin, darkening over time as result oxidation. Through understanding henna, encouraged consider influence reactions in daily lives. also promotes diversity inclusion...
To mitigate the global burden of antimicrobial resistance, we must develop antibiotics that are broadly effective, safe, and highly stable for purpose access. In this manuscript, report development polyacrylamide-based copolymers as a novel class broad-spectrum with efficacy against several critical pathogens. We demonstrate these copolymer drugs selective bacteria over mammalian cells, indicating favorable safety profile. show they kill through membrane disruption mechanism, which allows...
Here we present a hands-on module for high school students to explore the chemistry of henna dye. This lesson is affordable, accessible, adaptable, and engaging students. In this lesson, are shown how paste derived from shrub, discuss chemical structure main dye component lawsone (2-hydroxy-1,4-napthoquinone), apply their skin, darkening over time as result oxidation. Through understanding henna, encouraged consider influence reactions in daily lives. also promotes diversity inclusion...
Abstract The renin-angiotensin-aldosterone system (RAAS) plays a well-characterized role regulating blood pressure in mammals. Pharmacological and genetic manipulation of the RAAS has been shown to extend lifespan C. elegans , Drosophila rodents, but its mechanism is not well defined. Here we investigate angiotensin-converting enzyme (ACE) inhibitor drug captopril, which extends worms mice. To mechanism, performed forward screen for captopril hypersensitive mutants. We identified missense...