A5063372589- Nerve injury and regeneration
- Pharmacological Effects of Natural Compounds
- Chromatography in Natural Products
- Ginseng Biological Effects and Applications
- Liver physiology and pathology
- Natural product bioactivities and synthesis
- Nanoparticle-Based Drug Delivery
- Liver Disease Diagnosis and Treatment
- Essential Oils and Antimicrobial Activity
- Sirtuins and Resveratrol in Medicine
- Medicinal plant effects and applications
- RNA Interference and Gene Delivery
- Phagocytosis and Immune Regulation
- Cancer Research and Treatments
- Phytoestrogen effects and research
- Phytochemical and Pharmacological Studies
- Biochemical effects in animals
- Pharmacological Effects of Medicinal Plants
- Traditional Chinese Medicine Analysis
- Pesticide Residue Analysis and Safety
- Inflammasome and immune disorders
- Drug-Induced Hepatotoxicity and Protection
- Glycosylation and Glycoproteins Research
- Liver Diseases and Immunity
- Lipid Membrane Structure and Behavior
Beijing University of Chemical Technology
2023-2025
Hubei University of Chinese Medicine
2007-2025
Chengdu University of Traditional Chinese Medicine
2019
Shanghai Innovative Research Center of Traditional Chinese Medicine
2017
Ocean University of China
2017
Peng Huanwu Center for Fundamental Theory
2006
Office of Dietary Supplements
2002
University of Virginia
1993
Abstract The interactions between supramolecular nanofibers and proteins are crucial for functional biomaterials while there is lack of direct method to interpret nanofiber‐protein interactions. In parallel the single‐component system, here it demonstrated that deconvolution time‐resolved photoluminescence (PL) valid depict dynamic self‐assembly process two‐component systems including co‐assembly complexes. For a model assembling tetrapeptide FFKY, effects on fluorescence lifetime its...
Renal inflammation can result in renal injury. Uric acid (UA) is the final product of purine metabolism humans and because lack urate oxidase, UA may accumulate tissues, including kidney, causing inflammation. Galangin was isolated from a traditional Chinese medicine plant possesses several beneficial effects, working as an anti-oxidant, anti-mutagenic, anti-tumor, anti-inflammatory, anti-microbial, anti-viral agent. Therefore, this study aimed at investigating molecular mechanism galangin...
Hepatic fibrosis (HF) is a chronic hepatic pathological process induced by various liver injuries, with few available therapies. Previous research studies revealed that HF characterized the accumulation of excess extracellular matrix in liver, mainly overexpressed activated stellate cells (HSC). Therefore, HSC have been targeted clinical trials for management HF. The aim present study was to develop an anti-HF drug delivery system acrylic resin (Eudragit® RS100, Eud RS100) nanoparticles...
Bioorthogonal prodrug therapies offer an intriguing two-component system that features enhanced circulating stability and controlled activation on demand. Current strategies often deliver either the or its complementary activator to tumor with a monomechanism targeted mechanism, which cannot achieve desired antitumor efficacy safety profile. The orchestration of two distinct orthogonal mechanisms should overcome hierarchical heterogeneity solid tumors improve delivery efficiency both...
Hepatic fibrosis (HF) is a common disease, with currently no available treatment. Galangin, natural flavonoid extracted from Alpinia officinaruim Hance, has multiple effects demonstrated in previous studies. The aim of the present study was to explore anti-fibrogenic effect galangin vitro, and research its potential molecular mechanisms. LX-2 cells were chosen as an vitro HF model, treated different concentrations. Cell viability analyzed using Counting Kit-8 (CCK-8)...
Galangin has been reported to have many pharmacological effects including being anti-inflammatory, antibacterial, and antifungal a suppressor of vitiligo, Alzheimer’s disease, cancer. The purpose this research was characterize determine the efficacy antitumor activity pharmacokinetics galangin-loaded PEGylated liposomes compared with free galangin. Galangin-loaded were prepared using thin-film dispersion prior ultrasonication. mean particle size approximately 120 nm, polydispersity index...
Triterpenoid saponins from Kuding tea have demonstrated preventive effects on hyperlipidaemia induced by a high-fat diet. Lysoglycerophospholipids (Lyso-GPLs) are known to be associated with proatherogenic conditions such as hyperlipidaemia. In this study, target profiling strategy based multiple reaction monitoring mode was applied for the analysis of Lyso-GPLs. The metabolic changes were evaluated qualitative and relative quantitative distribution six classes Lyso-GPLs in mouse serum. A...
The purpose of this study was to prepare a liposomal temperature-sensitive gel able slowly release resveratrol after local intramuscular injection. best formulation liposomes based on the highest encapsulation efficiency and drug loading designed by Box-Behnken. prepared were approximately circular, with mean particle diameter <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mn>161.5</mml:mn><mml:mo>±</mml:mo><mml:mn>0.12</mml:mn><mml:mtext>...
This experiment determined the effects of liver transplantation on bile salt kinetics and biliary lipid secretion.Depression secretion in three main components cholesterol supersaturation with a high incidence stone formation have been documented patients end stage diseases after transplantation. However, physiologic changes recipients remain unclear.The study was done using rat transplant model 1 6 hours donor cold preservation saline. A chronic common duct fistula duodenal cannula were...
Oxidative stress is a hallmark in the pathogenesis of Parkinson disease (PD), which involves selective loss nigral dopaminergic neurons PD. Resveratrol (3,5,4'-trihydroxy-trans-stilbene) well known for its powerful antioxidant property and wide range other biological effects. In this study, we investigated protective effect resveratrol derived from Rhizoma Et Radix Polygoni Cuspidati liposomal form on cells PD rats induced by unilateral microinjection 6-hydroxy dopamine striatum. The results...