There is a major limitation in the immunotherapy for solid cancer that it only benefited minority of patients. This study aims to investigate whether differential composition lung microbiome could affect sustained clinical responses cancers treated with immunotherapy.

Purpose The purpose of this study is to examine talent management process in a region that has been influenced by Eastern culture. Design/methodology/approach This research multiple case six MNCs Asia. Cross-cases analysis was used reveal differences and similarities. data were collected through phone interviews with HR managers written communications as well organizations’ websites. Findings studied companies dealing several challenges regarding process, including attracting retaining...

IgA nephropathy (IgAN) is intimately linked to mucosal immune responses, with nasopharyngeal and intestinal lymphoid tissues being crucial for its abnormal immunity. The specific pathogenic bacteria in these sites associated IgAN, however, remain elusive. Our study employs 16S rRNA sequencing machine learning (ML) approaches identify locations investigate common pathogens that may exacerbate IgAN.

Rapid global development has resulted in the widespread use of water pipelines industrial and agricultural production life. During transportation deployment, pipes with different angles need to be positioned according geographical topographical problems. Flowmaster simulation software was used simulate leakage process angles. The transient characteristics fluids pipeline were studied detail. influences parameters, such as bending coefficient R/D (R is turning radius pipe, D inner diameter...

A new mechanophore was synthesized from a dithioester derivative 1 and an open-chain diene 2 by the HDA reaction. It embedded in polymer chain initiating polymerization of methyl acrylate (MA). found that PMA with Mn > 30 kDa could undergo mechanically induced retro RAFT-HDA reaction rapidly at ambient temperature. The released species evidenced chemically spectroscopically, liberated maintained activity to react cyclopentadiene (Cp) or copolymerize styrene (St).

Along with the rapid development of Internet, virtual community is gradually introduced into employees’ work and learning. There are many research studies about learning community, but few focus on working community. This examines a analyses its social network structure, measures centrality, tests relationship between centrality job performance. The online tutors at School Distance Learning in Peking University was object. Findings suggest that employees their performance have significant...

Underground pipeline networks constitute a major component of urban infrastructure, and thus, it is imperative to have an efficient mechanism manage them. This study introduces secondary development system efficiently model underground networks, using the building information modeling (BIM)-based software Revit. The comprises separate pipe point tubulation models. Using Revit application programming interface (API), spatial position attribute data points are extracted from database,...

Objectives Systemic Lupus Erythematosus (SLE) is a complex autoimmune disease that disproportionately affects women. Early diagnosis and prevention are crucial for women’s health, the gut microbiota has been found to be strongly associated with SLE. This study aimed identify potential biomarkers SLE by characterizing landscape using feature selection exploring use of machine learning (ML) algorithms significantly dysregulated microbiotas (SDMs) early identification patients. Additionally, we...

How can small firms manage and benefit from open innovation? We study three Taiwan's biotechnology leveraging innovation in developing new drugs. At the phase of drug discovery, two companies acquired technology external sources. CSRC Synpac Company Professor Yuan-Tsong Chen at Duke University (USA) 1991. GlycoNex Sen-itiroh Hakomori Washington 2001. AbGenomics developed its own Rong-Hwa Lin's team National Taiwan (Taiwan) 2000. Through transfer, licensed out Myozyme to Genzyme Corporation...

Most of the previous studies in global R&D were focused on developed economies, meaning situation developing countries has been neglected. Consequently, this work conducts a deep case study eight Taiwanese companies with overseas units. The sample came mainly from two industrial sectors: computer hardware and software. Preliminary research findings include following: (1) firms seem all to follow similar path internationalising their activities, (2) appear have same motivations use methods...

This study is mainly based on epistemic network analysis (ENA), and through the of interactive behaviors 131 learners in an online collaborative learning environment. Participants came from three classes they were assigned different multimedia materials (interactive, video text version) to complete a group worksheet discussion. By con-ducting analysis, differences between interaction found. it shown that class using version material communicate more harmoniously equally with each other,...

Digital instructional tools, such as virtual manipulatives, have been widely adopted an enhanced approach to inquiry-based learning. However, the optimal ratio of mobile devices students in settings remain controversial. This research introduced a counterbalanced quasi-experiment compare learning performance and group-process satisfaction (GS) primary school under various device-student ratios (1:1 or 1:m) external scripts (ES, with without). A total 128 sixth graders (11 drop-outs...

Abstract Introduction Children with autism (CWA) experience a high frequency of sleep disorders, which impact their well-being and development. Polysomnography faces challenges due to sensory sensitivities communication difficulties in CWA. Therefore, questionnaires play critical role gathering comprehensive information about patterns disturbances, potentially aiding the identification disorders. The diagnostic potential could facilitate earlier access tailored interventions for CWA,...

With the advancement of technology and improvement medical conditions, people around world are living longer. Meanwhile, low fertility rates have reduced proportion young workers. These two factors together driving global trend rapid population aging. The United Nations announced that world's has reached 8 billion on November 15, 2022, with 761 million aged 65 over, this number will increase to 1.6 by 2050, 80 over growing faster. pension crisis is gradually entering outbreak period, aging...

Comparison of Virtual Communication Environment for Remote BIM Model Review Collaboration Tzong-Hann Wu, Feng Shih-Chung Kang and Hung-Lin Chi Pages 1149-1154 (2019 Proceedings the 36th ISARC, Banff, Canada, ISBN 978-952-69524-0-6, ISSN 2413-5844) Abstract: building information modeling (BIM) model review collaboration is trend in architecture, engineering, construction (AEC) industry. communication environment a key factor successful collaboration. However, proper has yet to be fully...

In this paper, an A/D converter offering the high-to-low level shifter function applied to high range digital closed-loop MEMS accelerometer interface is presented. circuit, analog front-end circuit works in high-voltage domain and back-end low-voltage domain, however, cascade MASH 2-1 sigma-delta ADC just can achieve signal converting without introducing additional transition module. The mainly realized by first integrator means of using switched-capacitor charge transfer principle....

With the rapid growth of information technologies, collaborative R&D has become an important issue. Previous research indicates that collaboration is a means to accelerate commercialisation new create business, and reduce risk. Numerous studies focus on benefits, importance, risks disadvantages cooperation. Yet, performance measurements have received only scarce attention. While implementing collaboration, it believed managers will not be able efficiently manage product development without...

Precise behavioral models are needed to simulate switched-capacitor sigma-delta modulators more efficiently. This paper presents a new noise model of the operational amplifier (op-amp) used in typical correlated double sampling (CDS) integrator. Evaluation and validation done via transistor-level simulations for 2-1 MASH modulator using SIMULINK SPECTRE with 0.35um CMOS technology. Two sets results comparison obtained biggest difference between two simulators is around 2dB.

How can small firms manage and benefit from open innovation? We study three Taiwan's biotechnology leveraging innovation in developing new drugs. At the phase of drug discovery, two companies acquired technology external sources. CSRC Synpac Company Professor Yuan-Tsong Chen at Duke University (USA) 1991. GlycoNex Sen-itiroh Hakomori Washington 2001. AbGenomics developed its own Rong-Hwa Lin's team National Taiwan (Taiwan) 2000. Through transfer, licensed out Myozyme to Genzyme Corporation...