A5057597713- Glaucoma and retinal disorders
- Corneal Surgery and Treatments
- Intraocular Surgery and Lenses
- Corneal surgery and disorders
- Retinal Diseases and Treatments
- Retinal and Optic Conditions
- Ocular Surface and Contact Lens
- Retinal and Macular Surgery
- Infrared Thermography in Medicine
- Retinal Imaging and Analysis
- Retinal Development and Disorders
- Ocular and Laser Science Research
- Medical and Biological Sciences
- Ocular Diseases and Behçet’s Syndrome
- Thermoregulation and physiological responses
- Thermal Regulation in Medicine
- bioluminescence and chemiluminescence research
- Ocular Oncology and Treatments
- Neurological Disorders and Treatments
- Traumatic Ocular and Foreign Body Injuries
- Diverse Scientific Research in Ukraine
- Ocular Infections and Treatments
- Photoreceptor and optogenetics research
- Healthcare Systems and Public Health
- Vascular Malformations Diagnosis and Treatment
Filatov Institute of Eye Diseases and Tissue Therapy of the National Academy of Medical Sciences of Ukraine
2016-2025
The severe worldwide shortage of donor organs, and pathologies placing patients at high risk for rejecting conventional cornea transplantation, have left many corneal blind untreated. Following successful pre-clinical evaluation in mini-pigs, we tested a biomaterials-enabled pro-regeneration strategy to restore integrity an open-label observational study six patients. Cell-free implants comprising recombinant human collagen phosphorylcholine were grafted by anterior lamellar keratoplasty...
Abstract Corneas with severe pathologies have a high risk of rejection when conventionally grafted human donor tissues. In this early observational study, we bioengineered corneal implants made from recombinant collagen and synthetic phosphorylcholine polymer into three patients for whom cornea transplantation carried transplant failure. These suffered ulcers recurrent erosions preoperatively. The provided relief pain discomfort, restored integrity by promoting endogenous regeneration...
Perioperative monitoring of the ocular heat transfer is important for increasing safety long-term vitreoretinal surgery. The study aimed at studying new thermoelectric measuring devices comprehensive perioperative temperature and fluxes in This pilot, open-label, prospective included 23 patients (23 eyes) with proliferative diabetic retinopathy (PDR) both eyes. were developed intraocular surgery determining surface (OST) flux (HF) density. In all cases, OST HF density eyes recorded (before...
Purpose: To compare the 24-month efficacy of intravitreal ranibizumab and aflibercept in treatment-naive patients with myopic choroidal neovascularization (CNV). Methods: Ninety-six naive (97 eyes) CNV were included this single-center study. Patients received (IVR) or (IVA) following a pro re nata regimen (PRN). Results: Fifty (50 0.5 mg IVR, 46 (47 2.0 IVA. There was no significant between-group difference mean decimal best-corrected visual acuity (BCVA) (P = 0.6) central retinal thickness...
Abstract The paper describes the design and technical parameters of a medical thermoelectric device developed for diagnosing monitoring ophthalmic diseases. main elements are specially designed heat flux sensor thermocouple temperature connected to data acquisition unit. is micro-module that converts into an electric voltage, which recorded by measuring channel allows high-precision measurements both from ocular surface. contains examples clinical piloting device.
The purpose of this study was to evaluate the potential benefits intravitreal aflibercept injections for treatment choroidal neovascularization (CNV) secondary chorioretinitis.In uncontrolled, prospective cohort study, 15 eyes 14 consecutive patients affected by CNV associated with ocular toxoplasmosis were treated (2 mg) pro re nata and observed over a 12-month follow-up period. primary outcome change in best-corrected visual acuity (BCVA) from baseline month 12. Secondary outcomes included...
Currently, there are no clear recommendations about the safety of certain temperature conditions for intraocular structures during vitreoretinal surgery; instructions on safe rate rewarming vitreous cavity; and advisability monitoring ocular in postoperative period. The purpose was to study dynamics epibulbar surgery. This included 20 patients with rhegmatogenous retinal detachment (10 eyes) associated proliferative diabetic retinopathy eyes). All underwent In all cases, ambient temperature,...
Assessing heat flux (HF) is necessary for a complete understanding of transfer in the human body, as temperature measurements alone are insufficient. A comprehensive evaluation will expand our knowledge physiology and create new diagnostic possibilities, including ocular pathology. To evaluate surface HF density patients with diabetic retinopathy (DR). This study was pilot, prospective, open-label non-interventional. Eighty-four DR (168 eyes; aged 18–88 years) 30 healthy volunteers (60 18–85...
To examine the peculiarities of vitrectomy and morphologic changes in epiretinal membrane after intravitreal aflibercept patients with proliferative diabetic retinopathy.Prospective study 21 consecutive cases retinopathy complicated by vascularized forming tractional retinal detachment that underwent pars plana 4 days injection aflibercept. After removal, membranes were taken for histologic examination using light microscopy. Obliteration neovascularization membranes, lack bleeding...
To determine the efficacy of intravitreal aflibercept injections for treatment patients with choroidal neovascularization (CNV) associated pathologic myopia.In this uncontrolled, prospective cohort study, 31 eyes 30 consecutive affected by CNV myopia were treated (2 mg) as needed following two initial monthly doses and observed over a 12-month follow-up period. The primary endpoint was change in best-corrected visual acuity (BCVA) at month 12, while central retinal thickness (CRT) on optical...
Currently, much attention is paid to measuring the temperature of ocular surface in various ophthalmic diseases. However, for a comprehensive assessment heat transfer eye, it advisable measure both and flux (HF) density. This will expand our knowledge physiology eye create new possibilities diagnosing pathology. The present study aimed develop thermoelectric device rabbits' HF density.The multichannel was developed included ten rabbits (20 eyes). In all animals, density were measured on...
The present study aimed to evaluate the structure of rabbit retina after vitreoretinal surgery using prolonged irrigation with solutions different temperatures. Thirty-six rabbits (72 eyes) were included in this and randomly divided into 3 equal groups according temperature intraocular irrigating fluid they received during vitrectomy. Vitreoretinal was performed a 5°C solution group 1 (12 rabbits, 24 eyes), 22°C 2 36°C eyes). In each animals, mean irrigation/aspiration time 30 minutes for...
It was the aim of this study to determine efficacy intravitreal ranibizumab as treatment choroidal neovascularizations associated with pathologic myopia.In an uncontrolled, prospective time series cohort study, 65 eyes 64 consecutive patients neovascularization myopia were treated and observed over 12 months. The change in best-corrected visual acuity (BCVA) at 6 months served primary end point. Safety, central retinal thickness, activity on fluorescein angiography number injections...
Currently the only widely accepted corneal blindness treatment is human donor cornea transplantation. However, increasing shortage of corneas as well high risk rejection in some diseases remain two major problems, which limit success Corneal neovascularization considered one main factors graft failure. Different cell-free biosynthetic scaffolds fabricated from collagens or collagen-like peptides are being tested substitutes (DCS). Here, we report for first-time composite DCS with integrated...
Zusammenfassung Hintergrund Der große Mangel an Spendermaterial in der Ukraine macht es notwendig, zusätzliche Quellen von Transplantationsmaterial zu finden. Ein möglicherweise geeignetes Material ist die Hornhaut Schweinen, weil sie ihrer Struktur und ihren biomechanischen Parametern menschlichen ähnlich ist. Das Ziel unserer Studie war, Ergebnisse therapeutischen Keratoplastik (KP) mit Keratoxenotransplantaten aus gefriergetrockneten porcinen Xenotransplantaten bei Patienten schwerer...