A5005191568- Cancer Genomics and Diagnostics
- Circular RNAs in diseases
- Cancer, Hypoxia, and Metabolism
- Glioma Diagnosis and Treatment
- Advanced Proteomics Techniques and Applications
- Cancer-related molecular mechanisms research
- CAR-T cell therapy research
- Ubiquitin and proteasome pathways
- Molecular Biology Techniques and Applications
- Protein Degradation and Inhibitors
- Educational Methods and Media Use
- Retinal Diseases and Treatments
- MicroRNA in disease regulation
- Bioinformatics and Genomic Networks
- Ocular Oncology and Treatments
- RNA modifications and cancer
NYU Langone Health
2017-2020
New York University
2017-2019
Institute for Systems Biology
2019
Foothill College
2010
The Clinical Proteomic Tumor Analysis Consortium (CPTAC) has produced extensive mass spectrometry-based proteomics data for selected breast, colon, and ovarian tumors from Cancer Genome Atlas (TCGA). We have incorporated the CPTAC into cBioPortal to support easy exploration integrative analysis of these proteomic datasets in context clinical genomics same tumors. is an open source platform exploring, visualizing, analyzing multidimensional cancer data. public instance...
Highlights•BET target analysis reveals pro-tumorigenic genes in melanoma cells•The transmembrane molecule AMIGO2 and its interactor PTK7 regulate cell survival•AMIGO2 expression is controlled by BET proteins FOSL/TEAD TFs•The AMIGO2-PTK7 axis represents a potential therapeutic for melanomaSummaryBromodomain extraterminal domain inhibitors (BETi) represent promising agents metastatic melanoma, yet their mechanism of action remains unclear. Here we interrogated the transcriptional effects BETi...
Summary The Clinical Proteomic Tumor Analysis Consortium (CPTAC) has produced extensive mass spectrometry based proteomics data for selected breast, colon and ovarian tumors from Cancer Genome Atlas (TCGA). We have incorporated the CPTAC into cBioPotal to support easy exploration integrative analysis of these proteomic datasets in context clinical genomics same tumors. cBioPortal is an open source platform exploring, visualizing, analyzing multi-dimensional cancer data. public instance (...
PURPOSE: Optic gliomas are brain tumors characterized by slow growth, progressive loss of vision and limited therapeutic options. contain various amount myxoid matrix, which can represent majority the tumor mass. We sought to investigate biological function protein structure matrix in optic identify novel targets. EXPERIMENTAL DESIGN: reviewed histological features 120 gliomas, clinical imaging properties 10 analyzed vasculature immunohistochemistry electron microscopy 12 performed Liquid...
Abstract Metastasis is the primary cause of death cancer patients. Dissecting mechanisms governing metastatic spread may uncover new biology and/or yield promising therapeutic insights. Here we investigated role circular RNAs (circRNAs), a class noncoding lacking characterized functions, in metastasis, using melanoma as model aggressive tumor. We analyzed RNA-seq melanocytes and short-term cultures to characterize landscape circRNA melanocytic cells. observed silencing Cerebellar...