A5101770677- Cancer Research and Treatments
- Cancer Immunotherapy and Biomarkers
- Phytase and its Applications
- Peptidase Inhibition and Analysis
- Liver Disease Diagnosis and Treatment
- Cancer, Stress, Anesthesia, and Immune Response
- Diet, Metabolism, and Disease
- Genomics, phytochemicals, and oxidative stress
- 14-3-3 protein interactions
- Estrogen and related hormone effects
- Nitrogen and Sulfur Effects on Brassica
- Phytochemicals and Antioxidant Activities
- Bioactive Compounds and Antitumor Agents
- Bone Metabolism and Diseases
- Muscle and Compartmental Disorders
- Autophagy in Disease and Therapy
- Protease and Inhibitor Mechanisms
- Obesity, Physical Activity, Diet
- Signaling Pathways in Disease
- Cholesterol and Lipid Metabolism
- Liver physiology and pathology
- Urinary Bladder and Prostate Research
- Nutrition, Health and Food Behavior
- Tribology and Lubrication Engineering
- Text and Document Classification Technologies
Korea University
2015-2024
Hanyang University
2023-2024
Seoul National University Bundang Hospital
2019-2020
University of Mississippi
2020
National University College
2019
New Generation University College
2019
Seoul National University
2004-2014
The University of Texas MD Anderson Cancer Center
2005
Extracellular vesicles contain various cellular components that are involved in tumor growth, metastasis, and immune escape. classified into 2 groups, namely, exosomes microvesicles (MV). Although the formation roles of have been studied, exact functions MVs mechanisms underlying MV release not fully understood. We found epidermal growth factor accelerates from plasma membrane by inducing NF-κB activation CD133 expression. The amount sizes budding were to be dependent on expression level...
The first-line treatment for prostate cancer (PCa) is androgen ablation therapy. However, tumors generally recur and progress to androgen-independent PCa (AIPC) within 2–3 years. α-Actinin-4 (ACTN4) an actin-binding protein that belongs the spectrin gene superfamily acts as oncogene in various types. Although ACTN4 involved tumorigenesis epithelial–mesenchymal transition of cervical cancer, role remains unknown. We found expression level increased during from androgen-dependent AIPC....
The molecular mechanism of stress-induced hepatic steatosis is not well known. Human leucine zipper protein (LZIP) regulates the expression genes involved in inflammation, cell migration, and stress response. aim this study was to determine regulatory role LZIP steatosis. We used a microarray analysis identify LZIP-induced lipid metabolism. increased apolipoprotein A-IV (APOA4) mRNA. In presence inducer, APOA4 promoter performed, accumulation monitored mouse primary cells human tissues....
The study was conducted to investigate the effect of correct occlusion left atrial appendage (LAA) on intracardiac blood flow and thrombus formation in patients with fibrillation (AF) using four-dimensional (4D) magnetic resonance imaging (MRI) three-dimensional (3D)-printed phantoms.Three life-sized 3D-printed atrium (LA) phantoms, including a pre-occlusion (i.e., before procedure) model correctly incorrectly occluded post-procedural models, were constructed based cardiac computed...
Thioredoxin (Trx) is a multifunctional redox protein that has growth‐promoting and anti‐apoptotic effects on cells protects from endogenous exogenous free radicals. Recently, altered expression of Trx been reported in various cancers. In the present study, we investigated at precancerous carcinogenic phases during cholangiocarcinogenesis hamster cholangiocarcinoma (ChC) model, using semiquantitative immunohistochemical Western blot analyses. Moreover, to determine if results correlated well...
The nuclear transcription factor estrogen receptor α (ERα) plays a critical role in breast cancer progression. ERα acts as an important growth stimulatory protein and the expression level of is tightly related to prognosis treatment patients. Small leucine zipper (sLZIP) functions transcriptional cofactor by binding various receptors, including glucocorticoid receptor, androgen peroxisome proliferator-activated γ. However, sLZIP regulation its involvement progression unknown. We found that...
본 연구는 산업 부산물의 이용성 향상을 위하여 폐자원인 녹차씨 껍질 추출물의 미백 활성을 평가하기 수행되었다. 껍질로부터 유용성 성분을 얻기 에탄올 추출을 한 결과 건조중량 대비 1.24%의 수율을 얻을 수 있었고, DPPH 라디칼 소거능 및 tyrosinase 억제능을 관찰한 농도가 증가할수록 활성이 유의적으로 증가하는 것으로 나타났다. 또한 이러한 효과가 세포 내에서도 일어나는지에 관하여 알아보기 melanoma 세포인 B16BL6에 α-MSH를 처리하여 melanin의 형성을 촉진시키는 melanogenesis 과정을 유도한 후 추출물을 처리한 농도 의존적으로 형성이 감소되는 것을 알 있었다. 이상의 결과로 확인할 있었으며, 이를 활용하여 식품 화장품의 기능성 소재로 이용한다면 부산물인 껍질을 활용하는 차원에서 그 경제적 가치가 매우 클 사료된다.
본 연구에서는 논문이나 특허 등의 문서들의 인용 정보를 활용하여 연관성이 높고 중요한 특허를 추천하는 방법을 제안한다. 문서 간의 연관성 지표인 공통피인용횟수와 중요도 HITS를 적절한 형태로 결합한 뉴먼 커널로부터 두 정보의 반영 정도를 조율하는 것이 핵심이다. 제안하는 방법은 미래의 인용에 대한 예측 오차를 최소화하는 것으로 이를 통해 커널의 조율모수 <TEX>${\gamma}$</TEX>를 적절하게 선택할 수 있다. 또한, 거대 자료를 분석하기 위해 필요한 계산 기술에 대해서 자세히 논의한다. 마지막으로, 미국 등록 400만 건에 실증적 자료 분석을 시행한다. In this research, we propose a document recommendation method which can find documents that are relatively important to specific based on citation information. The key idea is...
Matrix metalloproteinases (MMPs) function as central modulators of tissue remodeling. Abnormal expression and altered activity MMPs result in excessive extracellular matrix degradation increased tumor metastasis various cancers. Small leucine zipper protein (sLZIP), belonging to the transcription factor family, functions a transcriptional regulator genes involved cellular processes. However, its role MMP castration-resistant prostate cancer (CRPC) remains unclear. In this study, we...
Abstract: An 18‐month‐old male Doberman Pinscher was referred to the Veterinary Medical Teaching Hospital of College Medicine for an erythemic nodular mass on right forelimb. The diagnosed as cutaneous lymphoma, based cytologic examination a aspirate and histopathology. Using immunohistochemistry neoplastic cells were positive CD3 but negative CD79a, E‐cadherin, pancytokeratin, confirming their origin T lymphocytes. No tumor recurrence noted 18 months after surgery. To our knowledge, this is...
The distribution header of small-scale steam systems, commonly employed in household items like cleaners, is pivotal for dictating the spray characteristics generated. For uniform performance across multiple outlets, it's imperative to discern design factors influencing this outcome. We numerically assessed flow a spraying system with three nozzle outlets and scrutinized impact parameters on uniformity. Through multiphase numerical model, simulations were conducted. Our analysis revealed...
We proposed a method to calculate the pressure, opening force, and leakage rate in mechanical seal under mixed lubricant state of gas liquid for reactor cooling pump (RCP) during external power loss. calculated pressure by solving nonlinear finite element equation composed linear Reynolds an incompressible compressible using Newton–Raphson method. In addition, we temperature distribution two-dimensional energy utilizing Additionally, included turbulence effect slip effects lubricant. The...
Abstract Hepatic gluconeogenesis is the central pathway for glucose generation in body. The imbalance between synthesis and uptake leads to metabolic diseases such as obesity, diabetes, cardiovascular diseases. Small leucine zipper protein (sLZIP) an isoform of LZIP it mainly functions a transcription factor. Although sLZIP known regulate genes involved various cellular processes, role hepatic metabolism not known. In this study, we investigated regulatory its involvement disorder. We found...