A5040157919- Cellular Mechanics and Interactions
- Force Microscopy Techniques and Applications
- Metal and Thin Film Mechanics
- 3D Printing in Biomedical Research
- Electronic and Structural Properties of Oxides
- Mesenchymal stem cell research
- Neurogenesis and neuroplasticity mechanisms
- Cell Adhesion Molecules Research
- Microfluidic and Bio-sensing Technologies
- Diamond and Carbon-based Materials Research
- Polymer Surface Interaction Studies
- Microstructure and mechanical properties
- Bone Tissue Engineering Materials
- Magnetic and transport properties of perovskites and related materials
- Elasticity and Material Modeling
- Concrete and Cement Materials Research
- Advancements in Solid Oxide Fuel Cells
- Tissue Engineering and Regenerative Medicine
- Advancements in Battery Materials
- Mechanical and Optical Resonators
- Corrosion Behavior and Inhibition
- Cancer Cells and Metastasis
- High Temperature Alloys and Creep
- Additive Manufacturing and 3D Printing Technologies
- Electrospun Nanofibers in Biomedical Applications
Massachusetts Institute of Technology
2015-2025
Singapore-MIT Alliance for Research and Technology
2012-2024
Cornell University
2023-2024
IIT@MIT
2018
Materials Processing (United States)
2015
National University of Singapore
2014
Material Sciences (United States)
2010
Harvard University
2003-2009
University of Colorado Boulder
2009
Massachusetts General Hospital
2009
Despite decades of studies calcium-silicate-hydrate (C-S-H), the structurally complex binder phase concrete, interplay between chemical composition and density remains essentially unexplored. Together these characteristics C-S-H define modulate physical mechanical properties this “liquid stone” gel phase. With recent determination calcium/silicon (C/S = 1.7) ratio particle (2.6 g/cm 3 ) by neutron scattering measurements, there is new urgency to challenge explaining essential properties....
Despite its ubiquitous presence in the built environment, concrete's molecular-level properties are only recently being explored using experimental and simulation studies. Increasing societal concerns about environmental footprint have provided strong motivation to develop new concrete with greater specific stiffness or strength (for structures less material). Herein, a combinatorial approach is described optimize of cement hydrates. The method entails screening computationally generated...
The adhesion and proliferation of bacteria on abiotic surfaces pose challenges related to human infection, including subsequent formation antibiotic-resistant biofilms in both healthcare industrial applications. Although the design antibacterial materials is a longstanding effort, surface properties that modulate viable bacteria—the critical first step biofilm formation—have been difficult decouple. This partial limited success due chiefly two factors. First, cells exhibit multiple, complex...
Nucleation and kinetics of defects at the atomic scale provide most fundamental information about mechanical response materials surfaces. Recent advances in experimental computational analyses allow us to study this phenomenon context nanoindentation localized probing Here, we present an analytical formulation elastic limit that predicts location slip character a homogeneously nucleated defect crystalline metals, extend form energy-based, local stability criterion, termed...
Young's modulus, hardness, and fracture toughness are measured by instrumented nanoindentation for an amorphous Li2S–P2S5 Li-ion solid electrolyte. Although low elastic modulus suggests accommodation of significant chemomechanical strain, can facilitate brittle crack formation in such materials.
Water within pores of cementitious materials plays a crucial role in the damage processes cement pastes, particularly binding material comprising calcium-silicate-hydrates (C-S-H). Here, we employed Grand Canonical Monte Carlo simulations to investigate properties water confined at ambient temperature and between C-S-H nanoparticles or "grains" as function relative humidity (%RH). We address effect on cohesion pastes by computing fluid internal pressures grains %RH intergranular separation...
ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionORIGINAL ARTICLEThis notice is a correctionSubstrata Mechanical Stiffness Can Regulate Adhesion of Viable BacteriaJenny A. Lichter, M. Todd Thompson, Maricela Delgadillo, Takehiro Nishikawa, Michael F. Rubner, and Krystyn J. Van Vliet*Cite this: Biomacromolecules 2008, 9, 10, 2967Publication Date (Web):August 28, 2008Publication History Published online28 August 2008Published inissue 13 October...
The concept of a "bound rubber" phase extending over nanometre-scale distances from the interface rubber-particle nanocomposites is generally accepted. However, thickness and elastic properties this interphase have not been confirmed by direct experimental observation. Here, we demonstrate existence bound rubber in hydrogenated nitrile butadiene (HNBR)–carbon black composites, through visualization measurement properties. Both macro- nanoscale mechanical analyses show that exhibits an...
Recent advances in contact mechanics have formalized approaches to distinguish between poroelastic and viscoelastic deformation regimes via load relaxation experiments, simultaneously extract the mechanical transport properties of gels at macroscale. As times scale quadratically with diameter, radii depths on mm can require hours for a single experiment complete. For degradable materials such as biodegradable hydrogels soft biological tissues, it is necessary minimize required experimental...
Efficient synchronization and selection of cells at different stages the cell replication cycle facilitates both fundamental research development cycle-targeted therapies. Current chemical-based methods are unfavorable as these can disrupt physiology metabolism. Microfluidic systems developed for physical separation offer a potential alternative over conventional approaches. Here we introduce spiral microfluidic device synchronization, using combined effects inertial forces Dean drag force....
Polymers that confer changes in optical properties response to chemical or mechanical cues offer diverse sensing applications, particularly if this stimuli is accessible humid aqueous environments. In study, luminescent hydrogels were fabricated using a facile process by incorporating lanthanide ions and carbon dots (CD) into network of polyacrylamide poly(acrylic acid). White luminescence was obtained tuning the balance blue-light-emitting CD green- red-light-emitting ions. Exploiting...
Significance We identify a set of unique biophysical markers multipotent mesenchymal stromal cell populations. Multivariate analysis cells from 10 adult and fetal bone marrow donors shows that distinct subpopulations exist within supposed stem populations are otherwise indistinguishable by accepted marker surface antigens. find although no single parameter is wholly predictive multipotency, three these together—cell diameter, mechanical stiffness, nuclear membrane fluctuations—distinguish...
The importance of concrete and cement to civil infrastructure cannot be overstated, yet there are still surprising gaps in our knowledge these systems, which unexpectedly complex. One basic example is that paste shrinks when water removed from its multiscale pore network, swells added, but the mechanism unclear. In a complete reassessment this phenomenon, authors differentiate physical behavior layered nanostructures hydrates larger gel capillary pores, linking microstructure macroscopic...