A5072982845- Circadian rhythm and melatonin
- Sleep and related disorders
- Sleep and Work-Related Fatigue
- Neurotransmitter Receptor Influence on Behavior
- Dietary Effects on Health
- Neuroendocrine regulation and behavior
- Adipose Tissue and Metabolism
- Stress Responses and Cortisol
- Climate Change and Health Impacts
- Spaceflight effects on biology
- Genetics, Aging, and Longevity in Model Organisms
- Receptor Mechanisms and Signaling
- Epigenetics and DNA Methylation
- Digital Mental Health Interventions
- Obstructive Sleep Apnea Research
- Obesity, Physical Activity, Diet
- Cannabis and Cannabinoid Research
- Neural and Behavioral Psychology Studies
- Impact of Light on Environment and Health
- Exercise and Physiological Responses
- Diabetes Management and Research
- Behavioral Health and Interventions
- Healthcare innovation and challenges
- Diet, Metabolism, and Disease
- European Law and Migration
National Institute for Public Health and the Environment
2015-2024
Health Forecasting
2018
University Medical Center Utrecht
2010-2015
Utrecht University
2013
The brain endocannabinoid system plays a crucial role in emotional processes. We have previously identified an important for endocannabinoids social play behavior, highly rewarding form of interaction adolescent rats. Here, we tested the hypothesis that modulation behavior occurs regions implicated emotion and motivation. Social increased levels anandamide amygdala nucleus accumbens (NAc), but not prefrontal cortex or hippocampus 4- to 5-week-old male Wistar Furthermore, phosphorylation CB1...
Background: Alcoholism is characterized by compulsive alcohol intake, but this critical feature of alcoholism seldom captured in preclinical studies. Here, we evaluated whether alcohol‐preferring C57BL/6J mice develop drinking patterns, using adulteration the solution with quinine, a limited access choice paradigm. We assessed 2 independent aspects drinking: (i) inflexible intake testing would drink bitter solutions if was their only source and (ii) indifferent comparing aversive nonaversive...
Many favorable metabolic effects have been attributed to thermogenic activity of brown adipose tissue (BAT). Yet, time day has rarely considered in this field research. Here, we show that a diurnal rhythm BAT regulates plasma lipid metabolism. We observed high-amplitude fatty acid uptake by synchronized with the light/dark cycle. Highest was found at onset active period, which coincided high lipoprotein lipase expression and low angiopoietin-like 4 BAT. Diurnal rhythmicity determined rate...
Abstract Disruption of circadian rhythm by means shift work has been associated with cardiovascular disease in humans. However, causality and underlying mechanisms have not yet established. In this study, we exposed hyperlipidemic APOE*3‐Leiden.CETP mice to either regular light‐dark cycles, weekly 6 hours phase advances or delays, alternating cycles (12 shifts), as a well‐established model for work. We found that 15 weeks displayed striking increase atherosclerosis, an approximately twofold...
Many molecular epidemiology studies focusing on high prevalent diseases, such as metabolic disorders and cancer, investigate hormonal markers. In general, sampling for these markers can occur at any time-point during the day or after an overnight fast. However, environmental factors, light exposure food intake might affect levels of markers, since they provide input internal time-keeping system. When diurnal variation is larger than inter-individual variation, time should be taken into...
Abstract During post‐weaning development, a marked increase in peer–peer interactions is observed mammals, including humans, which signified by the abundance of social play behaviour. Social highly rewarding, and known to be modulated through monoaminergic neurotransmission. Recently, habenula has received widespread attention because its role regulation neurotransmission as well variety emotional cognitive functions. Therefore, present study, we investigated involvement Using neuronal...
Positive social interactions during the juvenile and adolescent phases of life, in form play behavior, are important for cognitive development. However, neural mechanisms behavior remain incompletely understood. We have previously shown that methylphenidate atomoxetine, drugs widely used treatment attention-deficit hyperactivity disorder (ADHD), suppress rats through a noradrenergic mechanism action. Here, we aimed to identify substrates play-suppressant effects these drugs. Methylphenidate...
Abstract Night shift work is associated with increased health risks. Here we examined the association of metabolic risk factors and immune cell counts, both night particular characteristics thereof: frequency, duration consecutive shifts. We performed a cross-sectional study using data from 10,201 non-shift workers 1062 Lifelines Cohort study. Linear regression analyses, adjusted for demographic, lifestyle occupational factors, were used to associations counts. had an BMI, waist...
Night-shift work has been reported to have an impact on nutrition, daylight exposure, and physical activity, which might play a role in observed health effects. Because these exposures show diurnal variation, shift related with disturbances the circadian rhythm, timing of assessment factors requires careful consideration. Our aim was describe changes patterns diet, exposure associated night-shift work.We conducted observational study among female healthcare workers either regularly working...
Background: In the past years, an enormous increase in number of available health-related applications (apps) has occurred, from approximately 5800 2011 to over 23,000 2013, iTunes store. However, little is still known regarding use, possible effectiveness, and risks these applications. this study, we focused on apps other e-tools related medicine use. A large subset general population uses medicines might benefit tools that aid use medicine.
Frequent shift work causes disruption of the circadian rhythm and might on long-term result in increased health risk. Current biomarkers evaluating presence disturbance (CRD), including melatonin, cortisol body temperature, require 24-hr ("around clock") measurements, which is tedious. Therefore, these markers are not eligible to be used large-scale (human) studies. The aim present study was identify universal for CRD independent time day using a transcriptomics approach. Female FVB mice...
Abstract Disturbance of the circadian clock has been associated with increased risk cardio-metabolic disorders. Previous studies showed that optimal timing food intake can improve metabolic health. We hypothesized time-restricted feeding could be a strategy to minimize long term adverse health effects shift work and jetlag. In this study, we exposed female FVB mice weekly alternating light-dark cycles ( i . e 12 h shifts) combined ad libitum feeding, dark phase or at fixed time, in original...
Exposure to light at night (LAN) has been associated with serious pathologies, including obesity, diabetes and cancer. Recently we showed that 2 h of LAN impaired glucose tolerance in rats. Several studies have suggested the autonomic nervous system (ANS) plays an important role communicating these acute effects periphery. Here, investigated on liver transcriptome male Wistar Expression levels individual genes were not markedly affected by LAN, nevertheless pathway analysis revealed...
The postprandial glycemic response is an important metabolic health factor, which, from laboratory studies, known to change low high over the course of day, and which negative outcomes have been linked nightly eating. We applied interstitial continuous glucose monitoring examine a standardized carbohydrate-rich snack (198 kcal) across day in real-life setting. Twenty-four healthy participants (12 men, 12 women, 27-61 y old) consumed nine times during 6 d crossover design, altering time...
Sustained night shift work is associated with various adverse health risks, including an increased risk of cardiovascular disease, type II diabetes, and susceptibility to infectious respiratory diseases. The extent these effects, however, seems greatly vary between workers, yet the underlying reasons mechanisms interindividual differences remain poorly understood. Metabolomics assays in blood have recently gained much attention as a minimally invasive biomarker platform capturing information...