A5091117471- Vector-borne infectious diseases
- Mosquito-borne diseases and control
- Vibrio bacteria research studies
- Viral Infections and Vectors
- Autophagy in Disease and Therapy
- Antimicrobial Peptides and Activities
- Neurological diseases and metabolism
- Toxoplasma gondii Research Studies
- Plant Virus Research Studies
- Plant Parasitism and Resistance
- RNA regulation and disease
Université de Montpellier
2020-2024
Centre National de la Recherche Scientifique
2020-2024
Institut de Recherche en Infectiologie de Montpellier
2020-2024
Significance Coxiella burnetii is a stealth pathogen that evades innate immune recognition by inhibiting the NF-κB signaling pathway. This process mediated bacterial Dot/Icm secretion system; however, effector/s, as well molecular mechanism involved in this have remained unknown to date. Here, investigating C. proteins with eukaryotic-like features (EUGENs), we discovered new effector protein, NopA (nucleolar protein A), which localizes at nucleoli of infected cells and perturbs...
Coxiella burnetii, the etiological agent of zoonosis Q fever, replicates inside host cells within a large vacuole displaying autolysosomal characteristics. The development this compartment is mediated by bacterial effectors, which interfere with number membrane trafficking pathways. By screening transposon mutant library, we observed that insertions in cbu0626 led to intracellular replication and biogenesis defects. Here, demonstrate CBU0626 novel member vacuolar protein (Cvp) family...
Intracellular bacterial pathogens divert multiple cellular pathways to establish their niche and persist inside host. Coxiella burnetii , the causative agent of Q fever, secretes effector proteins via its Type 4 secretion system generate a -containing vacuole (CCV). Manipulation lipid protein trafficking by these effectors is essential for replication virulence. Here, we have characterized composition CCVs found that Vice interacts with phosphoinositides membranes enriched in...
The intracellular bacterial pathogen
Abstract Intracellular bacterial pathogens divert multiple cellular pathways to establish their niche and persist inside host. Coxiella burnetii , the causative agent of Q fever, secretes effector proteins via its Type 4 secretion system generate a -containing vacuole (CCV). Manipulation lipid protein trafficking by these effectors is essential for replication virulence. Here, we have characterized composition CCVs discovered that Vice interacts with phosphoinositides membranes enriched in...