A5043318546- 3D Printing in Biomedical Research
- Innovative Microfluidic and Catalytic Techniques Innovation
- Electrospun Nanofibers in Biomedical Applications
- Reproductive System and Pregnancy
- Cancer, Hypoxia, and Metabolism
- Reproductive Physiology in Livestock
- Nanoplatforms for cancer theranostics
- Click Chemistry and Applications
- Patient-Provider Communication in Healthcare
- Immunotherapy and Immune Responses
- Photodynamic Therapy Research Studies
- Liver physiology and pathology
- Galectins and Cancer Biology
- Tissue Engineering and Regenerative Medicine
- Endometrial and Cervical Cancer Treatments
- Microfluidic and Capillary Electrophoresis Applications
- Trauma and Emergency Care Studies
- Ovarian cancer diagnosis and treatment
- Sex and Gender in Healthcare
- Electronic Health Records Systems
- Estrogen and related hormone effects
- Healthcare Systems and Technology
- Microfluidic and Bio-sensing Technologies
- Immune Response and Inflammation
- Eosinophilic Esophagitis
Nazarbayev University
2021-2024
Photodynamic and photothermal therapies are promising treatments for cancer, dermatological, ophthalmological conditions. However, photodynamic therapy (PDT) is less effective in oxygen-deficient tumor environments. Combining PDT with (PTT) can enhance oxygen supply treatment efficacy. Inorganic PTT agents pose toxicity risks, limiting their clinical use despite high performance. In this study, we developed a novel nanomedicine integrating an all-organic agent organic photosensitizer,...
Here, we report a fluorescent electrospun nanofiber membrane for integration into microfluidic devices towards lung-on-a-chip applications complemented with the results of computational fluid dynamics modelling. A proposed hybrid poly(ε-caprolactone) (PCL)-collagen was developed, characterized, tested, and integrated prototype chip biocompatibility studies. The resulting has thickness approximately 10 μm, can be adjusted appropriate porosity, offers excellent mimicry basement to used in...
The pathogenesis of recurrent pregnancy loss (RPL) is multifactorial and not completely elucidated. Dysregulated immunity was implicated with RPL, in which regulatory T cells (Tregs) are key. As Tregs development function regulated by forkhead box P3 (FOXP3) transcription factor, as FOXP3 expression genetically determined, a role for polymorphisms RPL suggested.To investigate the association rs2294021, rs2232365, rs3761548, rs141704699 variants idiopathic Lebanese women.This retrospective...
Here, we present the development of first prototype a microfluidic chip with two compartments and nanofiber membrane for mimicking air-blood barrier toward integration into device use in lung-on-a-chip applications. A microchannels air cell culture media was developed. Thin film membranes have been developed fabricated comparison standard material reported devices. In this paper, preliminary results on design chip, thin-film membranes, electrospun membranes. Nanofiber made polycaprolactone...
Trauma remains one of the leading causes mortality worldwide, particularly among young population. A significant number people die within first 48 hours due to acute cardiovascular pathology. Cardiac injury is a predictor adverse outcomes following multiple trauma, associated with poor prognosis and prolonged hospitalization. Systemic elevation cardiac troponin levels linked survival, severity catecholamine consumption in patients after trauma. Clinical signs so-called "commotio cordis"...
The practice of gathering a patient's medical history has been cornerstone healthcare for centuries, providing the foundation accurate diagnoses and effective treatment plans. However, traditional face-to-face consultations have limitations, including incomplete histories due to time constraints potential communication barriers. To address these challenges, pre-consultation taking systems emerged as transformative solution, leveraging technology optimize data collection patient engagement....
Microfluidic organs-on-chips or microphysiological systems (MPS) are promising tools that can potentially replace animal testing in drug development. MPS platforms with microchannels seeded certain organ cells used to emulate vivo environments laboratory conditions. Among them, lung called lung-on-chip devices evaluate the influence of toxic particles, gases, and chemicals on tissue vitro. Lung-on-chip allow mimicry healthy conditions a wide range dis-eases (asthma, cancer, autoimmune,...
In this paper, we propose a new biocompatible PCL-collagen nanofiber membrane that could be integrated into microfluidic lung-on-a-chip device prototype. Membrane structure and properties were investigated using Scanning Electron Microscope (SEM), Fourier Transform Infrared (FTIR) spectroscopy, Mechanical tests, Contact angle measurements. Biocompatibility cytotoxicity of the on A549 adenocarcinoma human alveolar basal epithelial cell line Presto Blue Live/Dead assay. Additionally, sample...