A5032368980- Bee Products Chemical Analysis
- Phytochemistry Medicinal Plant Applications
- Essential Oils and Antimicrobial Activity
- Phytochemicals and Antioxidant Activities
- Insect and Pesticide Research
- Natural Antidiabetic Agents Studies
- Bioactive Compounds and Antitumor Agents
- Phytochemistry and biological activity of medicinal plants
- Antioxidant Activity and Oxidative Stress
- Phytochemicals and Medicinal Plants
- Free Radicals and Antioxidants
- Microbial Natural Products and Biosynthesis
- Women's cancer prevention and management
- Adipose Tissue and Metabolism
- Birth, Development, and Health
- Plant and animal studies
- Growth Hormone and Insulin-like Growth Factors
- Genetics, Aging, and Longevity in Model Organisms
- Toxin Mechanisms and Immunotoxins
- Cancer Treatment and Pharmacology
- Nanoparticles: synthesis and applications
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Treatments and Studies
- Chemotherapy-induced cardiotoxicity and mitigation
- Receptor Mechanisms and Signaling
Universidade Federal da Grande Dourados
2015-2024
King's College Hospital
2019
Guy's and St Thomas' NHS Foundation Trust
2019
St Thomas' Hospital
2014
Guy's Hospital
2014
Universidade Federal de São Paulo
2007-2008
Universidade de São Paulo
2006
Propolis from stingless bees Tetragonisca fiebrigi found in Brazil is used folk medicine by their nutritional and therapeutic properties. However, there are no scientific records evidencing such The present study was designed to investigate the chemical composition biological properties of propolis T. . For this, ethanol extract (EEP) determined GC-MS presented phenolic compounds, alcohol, terpenes as its major class compounds. antimicrobial activity accessed gram-positive gram-negative...
Renin-angiotensin system is involved in homeostasis processes linked to renal and cardiovascular recently has been metabolic syndrome. We analyzed the influence of long term angiotensin I converting enzyme (ACE) inhibitor enalapril treatment normotensive adult Wistar rats fed with standard or palatable hyperlipidic diets. Our results show that decreases absolute food intake, serum leptin concentration body weight gain. Moreover, adipose tissue, led decreased ACE activity, enhanced expression...
Propolis is a natural mixture of compounds produced by various bee species, including stingless bees. This compound has been shown to exhibit antioxidant, antiproliferative, and antitumor activities. The present study aimed determine the chemical constituents as well cytotoxic, toxic activities ethanol extracts propolis obtained from bees Scaptotrigona depilis Melipona quadrifasciata anthidioides , which are found in Brazil. Phytosterols, terpenes, phenolic compounds, tocopherol were...
Schinus terebinthifolius Raddi, Anacardiaceae, native to Brazil, is referred as "pimento-rosa" and used treat inflammatory disease in folk medicine. Studies have reported important pharmacological properties, but these effects still not been fully exploited. This study reports that the crude extract isolated compounds of S. (leaves) vitro antioxidant, antiproliferative, vivo anti-inflammatory activities. The samples were evaluated for antioxidant activity using 2,...
Hancornia speciosa Gomes (Apocynaceae) is a fruit tree, popularly known as mangabeira, and it widely distributed throughout Brazil. Several parts of the plant are used in folk medicine, leaf bark extracts have anti-inflammatory, antihypertensive, antidiabetic, antimicrobial properties. In this study, we investigated chemical composition ethanolic extract leaves (EEHS) its antioxidant, antimicrobial, cytotoxic activities well mechanisms involved cell death. The compounds were identified by...
Geopropolis is a resin mixed with mud, produced only by stingless bees. Despite being popularly known for its medicinal properties, few scientific studies have proven biological activities. In this context, the objective of study was to determine chemical composition and antioxidant, anti-inflammatory, antimutagenic antimicrobial activities Melipona orbignyi geopropolis. The hydroalcoholic extract geopropolis (HEGP) prepared determined high performance liquid chromatography coupled diode...
Propolis is a complex bioactive mixture produced by bees, known to have different biological activities, especially in countries where there rich biodiversity of plant species. The objective this study was determine the chemical composition and evaluate antioxidant cytotoxic properties Brazilian propolis from species Plebeia droryana Apis mellifera found Mato Grosso do Sul, Brazil. In ethanolic extracts P. (ExEP-P) A. (ExEP-A) acids, phenolic compounds, terpenes tocopherol were identified as...
Stryphnodendron adstringens (Mart.) Coville (Fabaceae) is a tree species native to the Brazilian Cerrado commonly known as barbatimão. In traditional medicine, decoctions or infusions of stem bark this plant are used in treatment several diseases. The objective study was analyze chemical composition aqueous extracts (SAAE) prepared from assess their antioxidant activity and anticancer effects well characterize cell death mechanisms against murine B16F10Nex-2 melanoma cells. From SAAE, gallic...
Natural products can be a source of biomolecules with antioxidant activity which are able to prevent oxidative stress-induced diseases and show antitumor activity, making them important sources new anticancer drug prototypes. In this context, study aimed analyze the chemical composition an ethanol extract Senna velutina leaves assess its cytotoxic activities in leukemic cells. The properties were evaluated using DPPH free radical scavenging assay by examining extract's inhibition...
Doxorubicin (DOX) is an efficient chemotherapeutic agent, but its clinical application limited by cardiotoxicity associated with increased oxidative stress. Thus, the combination of DOX and antioxidants has been encouraged. In this study, we evaluated (I) chemical composition antioxidant capacity aqueous extracts from Guazuma ulmifolia stem bark (GUEsb) leaves (GUEl) in 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) free radical scavenging, 2,2 ′ ‐azobis(2‐amidinopropane) dihydrochloride‐ (AAPH‐) or...
Fruits are sources of bioactive compounds that responsible for several biological activities. Therefore, this study aimed to identify the chemical composition pulp Brazilian Savanna fruit Dipteryx alata; evaluate its toxic effects, influence on life expectancy nematode Caenorhabditis elegans, and antioxidant activities in vitro vivo; describe mechanisms involved. The identified include phenols, terpenes, fatty acid derivatives, vitamins, a carboxylic acid. activity was demonstrated by...
Background and Purpose Leaves of Jacaranda decurrens are used in traditional Brazilian medicine to treat metabolic diseases related increased reactive oxygen species. The present study evaluated the antioxidant cytotoxic potential hydroethanolic extract from leaves subsp. symmetrifoliolata. Experimental Approach Phenolic compounds, flavonoids saponins were an ethanol∶water (80∶20, v/v) symmetrifoliolata (E-Jds). activity E-Jds was investigated by assessing following:...
Campomanesia adamantium O. Berg, popularly known as guavira, has been used in Brazilian traditional medicine for reduction of serum lipid. The present study was carried out to investigate the antioxidant and antihyperlipidemic effects root aqueous extract (ExCA). Phenolic compounds were quantified ExCA gallic ellagic acids identified by HPLC. showed efficiency 2,2-diphenyl-1-picrylhydrazyl free radical scavenging, with IC50 similar butylhydroxytoluene control, protected erythrocytes against...
Phytochemical studies are seeking new alternatives to prevent or treat cancer, including different types of leukemias. Campomanesia adamantium, commonly known as guavira guabiroba, exhibits pharmacological properties antioxidant, antimicrobial, and antiproliferative activities. Considering the anticancer potential this plant species, aim study was evaluate antileukemic activity chemical composition aqueous extracts from leaves (AECL) roots (AECR) C. adamantium their possible mechanisms...
Schinus terebinthifolius Raddi is a medicinal plant widely used for the treatment of various diseases. The secondary metabolites responsible pharmacological properties can be produced directly by or endophytic fungi. objective this study was to evaluate diversity fungi different parts S. and identify chemical compounds endophytes their antioxidant antibacterial activities. For this, fruits, stem bark roots were dried, ground placed in fungal growth medium. selected grown subjected extraction...
High levels of reactive oxygen species in the body and hyperlipidemia are key factors for development cardiovascular diseases such as atherosclerosis. The present study investigated antioxidant hypolipidemic activity hydroethanolic extract Curatella americana L. leaves (ExC). ExC was assessed by 2,2‐diphenyl‐1‐picrylhydrazyl free radical (DPPH) scavenging capacity protection against hemolysis induced 2,2′‐azobis(2‐amidinopropane) dihydrochloride (AAPH), followed quantification...