Paola dos Santos da Rocha

ORCID: 0000-0003-1019-1202
Publications
Citations
Views
---
Saved
---
About
Contact & Profiles
Research Areas
  • Phytochemistry Medicinal Plant Applications
  • Bee Products Chemical Analysis
  • Essential Oils and Antimicrobial Activity
  • Agricultural and Food Sciences
  • Phytochemicals and Medicinal Plants
  • Antioxidant Activity and Oxidative Stress
  • Phytochemicals and Antioxidant Activities
  • Natural Antidiabetic Agents Studies
  • Women's cancer prevention and management
  • Bioactive Compounds and Antitumor Agents
  • Insect and Pesticide Research
  • Microbial Natural Products and Biosynthesis
  • Phytochemistry and Bioactivity Studies
  • Phytochemistry and biological activity of medicinal plants
  • Nanoparticles: synthesis and applications
  • Insect Pest Control Strategies
  • Genetics, Aging, and Longevity in Model Organisms
  • Date Palm Research Studies
  • PARP inhibition in cancer therapy
  • Mangiferin and Mango Extracts
  • Fungal Biology and Applications
  • Chemotherapy-induced cardiotoxicity and mitigation
  • Dye analysis and toxicity
  • Herbal Medicine Research Studies
  • Food Science and Nutritional Studies

Universidade Federal da Grande Dourados
2015-2024

Propolis from stingless bees Tetragonisca fiebrigi found in Brazil is used folk medicine by their nutritional and therapeutic properties. However, there are no scientific records evidencing such The present study was designed to investigate the chemical composition biological properties of propolis T. . For this, ethanol extract (EEP) determined GC-MS presented phenolic compounds, alcohol, terpenes as its major class compounds. antimicrobial activity accessed gram-positive gram-negative...

10.1155/2015/296186 article EN Evidence-based Complementary and Alternative Medicine 2015-01-01

Fruits are sources of bioactive compounds that responsible for several biological activities. Therefore, this study aimed to identify the chemical composition pulp Brazilian Savanna fruit Dipteryx alata; evaluate its toxic effects, influence on life expectancy nematode Caenorhabditis elegans, and antioxidant activities in vitro vivo; describe mechanisms involved. The identified include phenols, terpenes, fatty acid derivatives, vitamins, a carboxylic acid. activity was demonstrated by...

10.3390/biom10081106 article EN cc-by Biomolecules 2020-07-25

Campomanesia adamantium O. Berg, popularly known as guavira, has been used in Brazilian traditional medicine for reduction of serum lipid. The present study was carried out to investigate the antioxidant and antihyperlipidemic effects root aqueous extract (ExCA). Phenolic compounds were quantified ExCA gallic ellagic acids identified by HPLC. showed efficiency 2,2-diphenyl-1-picrylhydrazyl free radical scavenging, with IC50 similar butylhydroxytoluene control, protected erythrocytes against...

10.1155/2016/7910340 article EN cc-by Oxidative Medicine and Cellular Longevity 2016-01-01

Schinus terebinthifolius Raddi is a medicinal plant widely used for the treatment of various diseases. The secondary metabolites responsible pharmacological properties can be produced directly by or endophytic fungi. objective this study was to evaluate diversity fungi different parts S. and identify chemical compounds endophytes their antioxidant antibacterial activities. For this, fruits, stem bark roots were dried, ground placed in fungal growth medium. selected grown subjected extraction...

10.3390/microorganisms8060859 article EN cc-by Microorganisms 2020-06-07

High levels of reactive oxygen species in the body and hyperlipidemia are key factors for development cardiovascular diseases such as atherosclerosis. The present study investigated antioxidant hypolipidemic activity hydroethanolic extract Curatella americana L. leaves (ExC). ExC was assessed by 2,2‐diphenyl‐1‐picrylhydrazyl free radical (DPPH) scavenging capacity protection against hemolysis induced 2,2′‐azobis(2‐amidinopropane) dihydrochloride (AAPH), followed quantification...

10.1155/2016/9681425 article EN cc-by Oxidative Medicine and Cellular Longevity 2016-01-01

Melipona quadrifasciata anthidioides and Scaptotrigona depilis are species of stingless bees capable producing propolis, which has considerable bioprospecting potential. In this context, the objective study was to determine chemical compositions evaluate antimicrobial activity propolis produced by M. q. S. depilis. The ethanolic extracts (EEP-M) (EEP-S) were prepared, their constituents characterized HPLC-ESI-MS. evaluated against bacteria fungi, isolated from reference strains hospital...

10.3390/microorganisms11010068 article EN cc-by Microorganisms 2022-12-26

Allophylus edulis is a Brazilian plant  commonly used in the mid-west region of Brazil for treatment disorders  related to oxidative stress such as diabetes, inflammation, hypertension and digestive diseases. The aims present study were quantify flavonoids phenolic compounds, evaluate antioxidant activity, antimicrobial effect acute toxicity leaves A. edulis. Ethanolic (EEAE) aqueous (AEAE) extracts prepared. activity was determined by 2.2-diphenyl-2-picrylhydrazyl (DPPH) free...

10.5897/ajpp2015.4270 article EN cc-by African Journal of Pharmacy and Pharmacology 2015-03-22

Obesity is a worldwide epidemic that reduces life expectancy; therefore, the search for new alternative and effective treatments ongoing. The aim of present investigation was to identify chemical compounds in hydroethanolic extract leaves Jacaranda decurrens subsp. symmetrifoliolata evaluate their toxicity antiobesity effects. High‐performance liquid chromatography used constituents, acute evaluated rats treated with doses 2 5 g·kg −1 body mass. effect determined hypercaloric diet‐induced...

10.1155/2016/4353604 article EN cc-by Evidence-based Complementary and Alternative Medicine 2016-01-01

Cerumen is a bee product produced exclusively by stingless bees, resulting from mixture of beeswax and plant resins. The antioxidant activity products has been investigated since oxidative stress associated with the onset progression several diseases that can lead to death. In this context, study aimed investigate chemical composition cerumen Geotrigona sp. Tetragonisca fiebrigi in vitro vivo. characterization extracts was performed HPLC, GC, ICP OES analyses. potential evaluated DPPH•...

10.3390/antiox12061276 article EN cc-by Antioxidants 2023-06-15

Campomanesia adamantium O. Berg. is a fruit tree species native to the Brazilian Cerrado biome whose fruits are consumed raw by population. The present study determined chemical composition of C. pulp (FPCA) and investigated its in vitro antioxidant potential biological effects Caenorhabditis elegans model. profile obtained LC-DAD-MS identified 27 compounds, including phenolic flavonoids, organic carboxylic acids, addition lipophilic pigments ascorbic acid. activity was analysed radical...

10.1371/journal.pone.0294316 article EN cc-by PLoS ONE 2023-11-16

Zootherapy is a traditional secular practice among the Guarani-Kaiowá indigenous ethnic group living in Mato Grosso do Sul, Brazil. My people use oil extracted from larvae of snout beetle Rhynchophorus palmarum (Linnaeus, 1758) to treat and heal skin wounds respiratory diseases. Based on this ethnopharmacological knowledge, chemical composition antioxidant, antimicrobial, healing properties R . (RPLO) were investigated, as well possible toxic effects, through vitro vivo assays. The RPLO was...

10.1371/journal.pone.0249919 article EN cc-by PLoS ONE 2021-04-29

Senna rugosa is a species found in the Cerrado and used folk medicine as vermifuge treatment of poisonous snakebites accidents. In this work, we identified main secondary metabolites present ethanolic extracts leaves (ELSR) roots (ERSR) S. evaluated potential cytoprotective effect against cellular macromolecular damage, well cytotoxic properties on K562 Jurkat leukemic cell lines. The identification was done by liquid chromatography coupled with mass spectrometry. antioxidant activities were...

10.20944/preprints202405.1172.v1 preprint EN 2024-05-17

Obesity is a pandemic disease characterized by lipid accumulation, increased proinflammatory cytokines, and reactive oxygen species. It associated with the development of comorbidities that lead to death. Additionally, drug treatments developed control obesity are insufficient have variety adverse effects. Thus, search for new anti-obesity therapies necessary. Campomanesia adamantium species from Brazilian Cerrado has potential treat obesity, as described antihyperlipidemic activity its...

10.3390/ph17081062 article EN cc-by Pharmaceuticals 2024-08-13

Obesity is an epidemic disease worldwide, associated with oxidative stress and the development of several other diseases. Bauhinia rufa (Bong.) Steud. a native Brazilian Cerrado medicinal plant popularly used for treatment obesity. In this context, we investigated chemical composition methanolic extract B. leaves (MEBr) evaluated antioxidant activity its impact on prevention obesity in mice fed high-fat diet (HFD 60%). Additionally, acute oral toxicity MEBr was evaluated. MEBr, 17...

10.1155/2022/8790810 article EN cc-by Oxidative Medicine and Cellular Longevity 2022-11-25
Coming Soon ...