A5067422042- Drug-Induced Adverse Reactions
- Skin Protection and Aging
- Food Allergy and Anaphylaxis Research
- Contact Dermatitis and Allergies
- SARS-CoV-2 and COVID-19 Research
- Statistical Methods in Clinical Trials
- Cutaneous Melanoma Detection and Management
- Inhalation and Respiratory Drug Delivery
- Biomedical Text Mining and Ontologies
- Indoor Air Quality and Microbial Exposure
- Dermatological and COVID-19 studies
- Radiomics and Machine Learning in Medical Imaging
- Health Systems, Economic Evaluations, Quality of Life
- Urban Green Space and Health
- Intramuscular injections and effects
- Venous Thromboembolism Diagnosis and Management
- Meta-analysis and systematic reviews
- Cancer Genomics and Diagnostics
- Artificial Intelligence in Healthcare and Education
- Peripheral Artery Disease Management
- Diagnosis and Treatment of Venous Diseases
- Electronic Health Records Systems
- Animal testing and alternatives
- Allergic Rhinitis and Sensitization
- AI in cancer detection
Technical University of Munich
2021-2024
Klinikum rechts der Isar
2024
University Medical Center of the Johannes Gutenberg University Mainz
2024
Johannes Gutenberg University Mainz
2024
Klinik und Poliklinik für Neurologie
2024
New York University Langone Orthopedic Hospital
1952
Cornell University
1952
Polyethylene glycol (PEG) may elicit anaphylaxis to COVID-19 mRNA vaccines, and guidance for patients at risk is needed.In retrospective with PEG allergy collected from 2006 till 2019, clinical, skin, basophil activation test (BAT) characteristics discriminative were analyzed compared the literature. In 421 prospective real-life asking workup vaccine hypersensitivity in 2020/2021, assessment was performed tolerance of recommended vaccination approach assessed.Ten found cohort. Patients...
Summary Background and objectives Cutaneous reactions following COVID‐19 vaccination have been frequently described, whereas larger case series by dermatologists are lacking. This study assesses SARS‐CoV‐2 vaccination‐associated skin reactions, severity, treatment, course, eliciting vaccines, allergy test results tolerance to revaccination. Patients methods Single‐institutional, non‐interventional of assessing cutaneous manifestations in 83 patients Germany. Results 93 were presented....
Basophil activation test (BAT) with COVID-19 mRNA vaccine seems particularly suitable for detecting sensitization to polyethylene glycol (PEG) in patients PEG allergy. It was the aim of this study determine cutoffs BAT using BNT162B2 (Comirnaty®) a larger group allergic and controls. 10 controls were studied. performed anti-CCR3 basophil identification anti-CD63 assess activation. Incubations at four different concentrations performed. significantly higher compared used. ROC curves showed...
ConclusionsThree organic mercurial preparations possessing diuretic activity were assayed by the oral route against Standard, mercuhydrin solution given intramuscularly, in patients with congestive failure. Of three materials, 3-chloro-mercuri-2-methoxy propylurea proved to be most effective, producing doses a response equivalent results obtained conventional of intramuscular mercuhydrin. The potency this compound when orally is somewhat more than one-fourth its injection, and latter 4.3...
Assessing the risk of bias (ROB) studies is an important part conduct systematic reviews and meta-analyses in clinical medicine. Among many existing ROB tools, Prediction Model Risk Bias Assessment Tool (PROBAST) a rather new instrument specifically designed to assess prediction studies. In our study we analyzed inter-rater reliability (IRR) PROBAST effect specialized training on IRR. Six raters independently assessed all melanoma published until 2021 (n = 42) using instrument. The evaluated...
Tanning beds have been classified as carcinogenic to humans. As a result, many countries enacted laws regulating the use of commercial tanning beds, including bans for minors. However, there is no international overview current legal status access restrictions minors that provides details on their specific design regarding age limits and possible exceptions statutory regulation. Therefore, we performed comprehensive web search bed legislation three continents North America, Australia,...
Tanning beds have been classified as carcinogenic to humans. As a result, many countries enacted laws regulating the use of commercial tanning beds, including bans for minors. However, there is no international overview current legal status access restrictions minors that provides details on their specific design regarding age limits and possible exceptions statutory regulation. Therefore, we performed comprehensive web search bed legislation three continents North America, Australia,...
Abstract Background Vaccination of the population is required to combat COVID‐19 pandemic. Allergy testing could reduce anxiety towards vaccination and thereby may increase rate, however, its effectiveness remains unclear. Methods One hundred thirty prospective real‐life patients in need but not daring get vaccinated asked for allergy workup vaccine hypersensitivity 2021/2022. Characterization patients, identification anxieties, decrease patient's levels, overall rate adverse reactions after...
Rare gynecological tumors (RGTs) present major clinical challenges due to their low incidence and heterogeneity. The lack of clear guidelines leads suboptimal management poor prognosis. Molecular tumor boards accelerate access effective therapies by tailoring treatment based on biomarkers, beyond cancer type. Unstructured data that requires manual curation hinders efficient use biomarker profiling for therapy matching. This study explores the large language models (LLMs) construct digital...
PURPOSE Rapidly expanding medical literature challenges oncologists seeking targeted cancer therapies. General-purpose large language models (LLMs) lack domain-specific knowledge, limiting their clinical utility. This study introduces the LLM system Medical Evidence Retrieval and Data Integration for Tailored Healthcare (MEREDITH), designed to support treatment recommendations in precision oncology. Built on Google's Gemini Pro LLM, MEREDITH uses retrieval-augmented generation chain of...
More than twenty-five years ago, the Global Solar UV index (UVI) was introduced as a simple means of visualizing intensity ultraviolet radiation and to alert people need for sun protection. In our survey, among directors 436 kindergartens in southern Germany we investigated level awareness knowledge about UVI well practical consequences protection kindergartens. Less half (n = 208, 47.7%) had ever heard UVI, only small minority them 34, 8.7%) used daily information adapt protective measures...
Transparent and accurate reporting is essential to evaluate the validity applicability of risk prediction models. Our aim was quality studies developing validating models for melanoma according TRIPOD (Transparent Reporting a multivariate model Individual Prognosis Or Diagnosis) checklist. We included that were identified by recent systematic review updated literature search ensure our rating all relevant studies. Six reviewers assessed compliance with 37 components each study using...
Rising incidences of cutaneous melanoma have fueled the development statistical models that predict individual risk. Our aim was to assess validity published prediction for incident using a standardized procedure based on PROBAST (Prediction model Risk Of Bias ASsessment Tool). We included studies were identified by recent systematic review and updated literature search ensure our rating all relevant studies. Six reviewers assessed risk bias (ROB) each study “PROBAST Assessment Form”...
e13609 Background: Precision oncology revolutionized cancer treatment by identifying molecular biomarkers to guide personalized care. The ever-growing body of medical literature presents a challenge for oncologists researching targeted therapies. While recent studies investigated large language models (LLMs) streamline this process, LLM reliance on general rather than knowledge limits clinical relevance and trustworthiness. To address these limitations, we developed retrieval augmented...
Hautreaktionen nach COVID-19-Impfung werden in dieser Studie präzise mitsamt Schweregrad, Verlauf, Therapie, auslösender Impfstoffe, allergologischer Abklärung und der Verträglichkeit Folgeimpfung untersucht.83 Patienten wurden monozentrischen an einer dermatologischen Universitätsklinik untersucht.Die Manifestationen (n = 93) gliederten sich Sofort-Überempfindlichkeitsreaktionen angelehnt Soforttypallergien 51; 54,8%), verzögerte Überempfindlichkeitsreaktionen Spättypallergien 10; 10,8%),...
Artificial ultraviolet radiation from tanning beds has been classified as carcinogenic by the International Agency for Research on Cancer in 2009. Several countries have subsequently introduced comprehensive legislation regulating commercial indoor tanning. Specific aspects of these regulations address bed advertising and information requirements customers, which previously neglected international comparisons regulations. We performed a systematic search regarding 131 legislative units...
Rising incidences of cutaneous melanoma have fueled the development statistical models that predict individual risk. Our aim was to assess validity published prediction for incident using a standardized procedure based on PROBAST (Prediction model Risk Of Bias ASsessment Tool). We included studies were identified by recent systematic review and updated literature search ensure our rating all relevant studies. Six reviewers assessed risk bias (ROB) each study “PROBAST Assessment Form”...
More than twenty-five years ago the Global Solar UV index (UVI) has been introduced as a simple means of visualizing intensity ultraviolet radiation and to alert people need for sun protection. In our survey among directors 436 kindergartens in southern Germany we investigated level awareness knowledge about UVI well practical consequences protection kindergartens. Less half (n=208, 47.7%) had ever heard UVI, only small minority them (n=34, 8.7%) used daily information adapt protective...