Abstract. An open, randomized, cross‐over study was undertaken to assess the effects of lisinopril and nifedipine on albumin excretion, renal haemodynamics segmental tubular reabsorption in overt diabetic nephropathy. The consisted a 4‐week run‐in period, 3‐week active treatment wash‐out period second period. Twelve patients with type 1 diabetes albuminuria, mild moderate hypertension serum creatinine level < 200 μmol l −1 were included. Lisinopril reduced excretion from 1343 ± 337 μg min...

Climate therapy (heliotherapy) of psoriasis is an effective and natural treatment. Ultraviolet radiation (UVB) from the sun improves induces vitamin D(3) synthesis.The aim study was to investigate effect climate on synthesis, blood glucose, lipids B12 in patients.Twenty Caucasian patients (6 women 14 men; mean age, 47.2 years; range, 24-65) with moderate severe [mean Psoriasis Area Severity Index (PASI) score 9.8; 3.8-18.8] received at Gran Canarias for 3 weeks. Blood samples were drawn...

The aims of this study were to improve the algorithms for calculating a transcutaneous bilirubin index (TcB), follow concentrations during phototherapy and evaluate possible changes in skin optical parameters such as pigmentation erythema phototherapy.Reflectance measurements performed on 51 jaundiced newborns, which 10 subjected phototherapy. collected with diode array spectrophotometer an integrating sphere accessory, TcB was calculated from measured spectra using based diffusion theory....

Multiband filter radiometers (MBFRs) are extensively used in national measurement networks for UV climate monitoring and informing the public about potential health risks from excessive solar exposure. Results first international intercomparison of MBFRs, arranged Oslo 2005, presented. Forty‐three type GUV, NILU‐UV, UVMFR‐7 were assembled, representing stations on several continents. The objective was to conduct a blind Global Index (UVI) processed by instrument owners. Eleven independent...

Indoor tanning increases skin cancer risk, but the importance of different parts UV spectrum is unclear. We assessed irradiance devices in Norway for period 1983-2005. Since 1983, all models needed approval before being sold or used. Type 3 limits were valid from late 1992 (<0.15 W m(-2) CIE-weighted, i.e. erythemally weighted, short and long wave irradiances). analyzed data 90% approved (n = 446 models) two large inspection surveys 1998/1999 2003 1,341 devices). Mean CIE-weighted increased...

Breslow thickness is the most important prognostic factor of localized cutaneous melanoma (CM), but associations with anthropometric factors have been sparsely and incompletely investigated.To examine prediagnostic body mass index (BMI), surface area (BSA), height, weight change in relation to thickness, overall by anatomical site histological subtype; assess possible nonlinear between these thickness.CMs Janus Cohort were identified 1972 2014. Linear regression was used estimate geometric...

The aim of the present study was to prospectively examine risk cutaneous melanoma (CM) according measured anthropometric factors, adjusted for exposure ultraviolet radiation (UVR), in a large population-based cohort Norway. Janus Cohort, including 292,851 Norwegians recruited 1972-2003, linked Cancer Registry Norway and followed CM through 2014. Cox regression used estimate hazard ratios (HRs) with 95% confidence intervals (CIs). Restricted cubic splines were incorporated into models assess...

Background/purpose: Psoriasis is a chronic inflammatory disease affecting about 2–3% of the population. Sun exposure has positive effect on most lesions, but ultraviolet (UV) radiation also constitutes carcinogenic potential. Climate therapy frequently used to treat patients, with consequence that they may receive high doses UV. This paper explores UV patients treated in Gran Canaria. Methods: Patient have been estimated for 20 psoriasis during 15‐day climate study and compared predetermined...

Norway has one of the highest incidences melanoma in world. It been suggested that majority all skin cancers could be prevented by changes related to sun-tanning behaviour. This study explores behaviour Norwegian population using a modified Health Belief Model (HBM). Increased knowledge about beliefs, attitudes and can provide information which may useful for future sun protection interventions. In 2017, 1004 members completed cross-sectional online surveys. People who seek tanning purposes...

The use of UV-emitting tanning devices for cosmetic purposes is associated with an increased risk melanoma and non-melanoma skin cancer. Young women are the most frequent users, therefore, there increasing concern about regulation sunbed use.The primary objective to assess current legislation on among European countries.We developed a 30-item questionnaire gather relevant information legislation. was sent Euromelanoma coordinators designated out network.We obtained response rate 64%. More...

Abstract Previous studies of serum 25-hydroxyvitamin D (25(OH)D) in relation to melanoma have shown conflicting results. We conducted a nested case–control study 708 cases and controls, using prediagnostically collected serum, 25(OH)D risk the population-based Janus Serum Bank Cohort. Stratified Cox regression was used estimate hazard ratios (HRs) with 95% confidence intervals (CIs) adjusted for ultraviolet radiation (UVR) indicators stratified by ambient UVB residence body mass index (BMI)....

Abstract. Psoriasis is a chronic inflammatory disease involving about 2–3% of the Norwegian population. Sun exposure has positive effect on most psoriasis lesions, but ultraviolet (UV) radiation also causes direct DNA damage in skin cells and comprises carcinogenic potential. UV local as well systemic immune suppressive effect, relation between sun these biological effects not known. In March 2006 study was carried out to investigate possible therapeutic outcome mechanisms 20 patients...

The Norwegian UV-monitoring network, implemented in 1995, has provided up to 16 years measurement data from currently 9 stations located 59° N 79°N. intention is provide measurements of high scientific quality for the spatial and temporal variability UV information public about solar exposure. are equipped with GUV multiband filter radiometers Biospherical Instruments Inc. irradiance scale maintained a travelling reference instrument, traceable QASUME European spectroradiometer. Blind test...

The principle of laser induced selective photothermolysis is to thermal damage specific targets in such a manner that the temperature surrounding tissue maintained below threshold for damage. selectivity obtained by selection proper wavelength and pulse duration. technique presently being used clinic removal port-wine stains. presence melanin epidermal layer can represent limitation selectivity. Melanin absorption drops off significantly with increasing wavelength, but significant entire...

The pulsed dye laser is the most efficient to treat port wine stains. Mathematical modeling predicts that incident optical fluence required coagulate small sized and/or deeply located vessels larger than threshold value for epidermal damage. Dynamic cooling has been reported prevent damage caused by absorption of energy in melanin. Further on, this technique proved reduce pain associated with therapy. aim our study was examine possible clinical advantages dynamic cooling. A flash lamp pumped...

The clinical objective in treatment of port wine stains is to maximize thermal damage the abnormal blood vessels without introducing normal overlying epidermis. rationale dynamic cooling protect epidermis from by selectively this layer down immediately before delivering laser pulse. This work discusses dynamics epidermal milliseconds cryogen spurts and melanosomal heating

Artificial ultraviolet radiation from tanning beds has been classified as carcinogenic by the International Agency for Research on Cancer in 2009. Several countries have subsequently introduced comprehensive legislation regulating commercial indoor tanning. Specific aspects of these regulations address bed advertising and information requirements customers, which previously neglected international comparisons regulations. We performed a systematic search regarding 131 legislative units...

A survey was undertaken regarding the extent to which optical radiation is used in cosmetic treatments and compliance with national regulations. Questionnaires were sent 65 clinics, 23 of these later inspected. Only one 41 class 4 lasers had been reported authorities according regulations prior survey. Among sources other than lasers, intense pulsed light (IPL) most frequent. Although qualified health personnel should be charge treatment, it observed that 30% clinics did not fulfil this...

The visual appearance of port-wine stain lesions is often a red to purple color due an enlarged blood volume in the upper dermis. purpose treatment re-establish normal skin coloration. Visual reflectance spectra should therefore, principle, contain all relevant information about lesion. influence on from different tissue parameters, such as melanin, content and scattering, rather composite. However, simple mathematical model can give good understanding relevance components. This knowledge be...