A5103092106- Hippo pathway signaling and YAP/TAZ
- Neurobiology and Insect Physiology Research
- Developmental Biology and Gene Regulation
- Cellular Mechanics and Interactions
- Mosquito-borne diseases and control
- Click Chemistry and Applications
- Signaling Pathways in Disease
- Plant Reproductive Biology
- Insect and Arachnid Ecology and Behavior
- Biotin and Related Studies
- RNA Research and Splicing
- Fossil Insects in Amber
- Biochemical and Molecular Research
- Animal Behavior and Reproduction
- Reproductive Biology and Fertility
- Cytokine Signaling Pathways and Interactions
- interferon and immune responses
- Trypanosoma species research and implications
- Insect symbiosis and bacterial influences
- Retinoids in leukemia and cellular processes
- Plant Molecular Biology Research
- Hedgehog Signaling Pathway Studies
- Insect and Pesticide Research
- Cancer-related gene regulation
National Cheng Kung University
2013-2025
Johns Hopkins University
2007-2013
Johns Hopkins Medicine
2007
Significance Understanding the molecules that govern production of specific cell types from adult tissue stem cells is a major challenge, and Drosophila follicle (FSCs) are an outstanding model. We report identification gene, castor , which required for FSC maintenance. Castor also functions in genetic circuit with two other genes, hedgehog eyes absent to determine progeny fates. Our studies provide marker earliest cell-fate decisions this model insight into molecular cellular mechanisms by...
Abstract Aurantiochytrium are protists found in marine and estuarine environments, known for producing high quantities of omega-3 fatty acids, particularly docosahexaenoic acid (DHA). The commercial viability this species is currently hindered by the lack reliable screening methods rapid identification strains with DHA content. This study developed a high-throughput platform based on sulfo-phospho-vanillin (SPV) reaction, which produces pink chromophore upon reacting C–C double bonds lipids....
Dengue fever is one of the most severe viral diseases transmitted by Aedes mosquitoes, with traditional approaches disease control proving insufficient to prevent significant burden. Release Wolbachia-transinfected mosquitoes offers a promising alternative methodologies; female aegypti demonstrate reduced dengue virus transmission, whilst males cause zygotic lethality when crossed uninfected females, providing method for suppressing mosquito populations. Although highly promising, delicate...
In collective cell migration, directional protrusions orient cells in response to external cues, which requires coordinated polarity among the migrating cohort. However, molecular mechanism has not been well defined. Drosophila border (BCs) migrate collectively and invade via confined space between nurse cells, offering an vivo model examine how group is organized. Here, we show that front/back of BCs Rap1, hyperactivation disrupts cluster induces misoriented loss asymmetry actin network....
Collective migration is important to embryonic development and cancer metastasis, but migratory nonmigratory cell fate discrimination by differential activity of signal pathways remains elusive. In Drosophila oogenesis, Jak/Stat signaling patterns the epithelial fates in early egg chambers later renders motility clustered border cells. How spatiotemporally switches static epithelia motile cells largely unknown. We report that a nuclear protein, Dysfusion, resides on inner membrane interacts...
Enzyme-catalyzed proximity labeling is a potent technique for the discernment of subtle molecular interactions and subcellular localization, furnishing contextual insights into protein interest within cells. Although ascorbate peroxidase2 (APEX2) has proven effective in this approach when overexpressed, its compatibility with endogenous proteins remains untested. We improved studying native protein-protein live
Phosphatidylinositol (PI) 4,5-bisphosphate (PIP2) is involved in many biological functions. However, the mechanisms of PIP2 collective cell migration remain elusive. This study highlights regulatory role cytidine triphosphate synthase (CTPsyn) border through regulating asymmetrical distribution PIP2. We demonstrated that clusters containing mutant CTPsyn cells suppressed migration. was co-enriched with Actin at leading edge Drosophila cluster where enriched, and this enrichment depended on...