A5041954439- interferon and immune responses
- RNA Research and Splicing
- Trypanosoma species research and implications
- Retinoids in leukemia and cellular processes
- Cytokine Signaling Pathways and Interactions
- Biotin and Related Studies
- Click Chemistry and Applications
- Signaling Pathways in Disease
- Biochemical and Molecular Research
National Cheng Kung University
2022-2024
Collective migration is important to embryonic development and cancer metastasis, but migratory nonmigratory cell fate discrimination by differential activity of signal pathways remains elusive. In Drosophila oogenesis, Jak/Stat signaling patterns the epithelial fates in early egg chambers later renders motility clustered border cells. How spatiotemporally switches static epithelia motile cells largely unknown. We report that a nuclear protein, Dysfusion, resides on inner membrane interacts...
Enzyme-catalyzed proximity labeling is a potent technique for the discernment of subtle molecular interactions and subcellular localization, furnishing contextual insights into protein interest within cells. Although ascorbate peroxidase2 (APEX2) has proven effective in this approach when overexpressed, its compatibility with endogenous proteins remains untested. We improved studying native protein-protein live
Phosphatidylinositol (PI) 4,5-bisphosphate (PIP2) is involved in many biological functions. However, the mechanisms of PIP2 collective cell migration remain elusive. This study highlights regulatory role cytidine triphosphate synthase (CTPsyn) border through regulating asymmetrical distribution PIP2. We demonstrated that clusters containing mutant CTPsyn cells suppressed migration. was co-enriched with Actin at leading edge Drosophila cluster where enriched, and this enrichment depended on...